Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6665

Name

SOX15

Synonymous

SRY (sex determining region Y)-box 15;SOX15;SRY (sex determining region Y)-box 15

Definition

SRY (sex determining region Y)-box 20|protein SOX-15

Position

17p13.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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There is no record for SOX15

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.241A>C; p.K81Q; 17:7589436-7589436

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.580C>T; p.Q194*; 17:7588500-7588500

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.580C>T; p.Q194*; 17:7588500-7588500

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Nonsense

c.355C>T; p.R119W; 17:7589322-7589322

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.72_74delCTC; p.S27delS; 17:7589603-7589605

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.72_74delCTC; p.S27delS; 17:7589603-7589605

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38G>T; p.S13I; 17:7589639-7589639

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.45G>T; p.E15D; 17:7589632-7589632

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.219G>T; p.K73N; 17:7589458-7589458

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.580C>G; p.Q194E; 17:7588500-7588500

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.289C>T; p.P97S; 17:7589388-7589388

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.430G>A; p.G144S; 17:7589247-7589247

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.681delC; p.M228fs*3; 17:7588399-7588399

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.241A>G; p.K81E; 17:7589436-7589436

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.210G>A; p.Q70Q; 17:7589467-7589467

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.561C>G; p.P187P; 17:7588519-7588519

 prostatecarcinomaSubstitution - coding silent

c.39C>T; p.S13S; 17:7589638-7589638

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.659A>C; p.N220T; 17:7588421-7588421

 breastcarcinomaSubstitution - Missense

c.88delC; p.Q30fs*20; 17:7589589-7589589

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IIDeletion - Frameshift

c.671C>T; p.A224V; 17:7588409-7588409

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.673G>C; p.G225R; 17:7588407-7588407

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.184G>A; p.A62T; 17:7589493-7589493

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.129G>A; p.T43T; 17:7589548-7589548

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

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