General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information |
|
---|---|
Gene ID | 678 |
Name | ZFP36L2 |
Synonymous | ZFP36 ring finger protein-like 2;ZFP36L2;ZFP36 ring finger protein-like 2 |
Definition | EGF-response factor 2|ZFP36-like 2|butyrate response factor 2|zinc finger protein 36, C3H type-like 1|zinc finger protein 36, C3H type-like 2|zinc finger protein 36, C3H1 type-like 2|zinc finger protein, C3H type, 36-like 2 |
Position | 2p22.3-p21 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
Loss of Function mutations compare to missense mutations | Top |
The ratio of the loss-of-function mutations over missense mutations is 0.42. |
The copy number variations for various cancers | Top |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
---|---|---|---|
c.528C>A; p.F176L; 2:43225276-43225276 |
central_nervous_system; brain | glioma; oligodendroglioma_Grade_III | Substitution - Missense |
c.875C>T; p.S292F; 2:43224929-43224929 |
skin | malignant_melanoma | Substitution - Missense |
c.222C>A; p.C74*; 2:43225582-43225582 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.303_304insT; p.K102fs*1; 2:43225500-43225501 |
endometrium | carcinoma; endometrioid_carcinoma | Insertion - Frameshift |
c.910T>G; p.S304A; 2:43224894-43224894 |
liver | carcinoma | Substitution - Missense |
c.910T>G; p.S304A; 2:43224894-43224894 |
liver | carcinoma | Substitution - Missense |
c.910T>G; p.S304A; 2:43224894-43224894 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.910T>G; p.S304A; 2:43224894-43224894 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.910T>G; p.S304A; 2:43224894-43224894 |
liver | carcinoma | Substitution - Missense |
c.868C>T; p.P290S; 2:43224936-43224936 |
pancreas | carcinoma | Substitution - Missense |
c.1070C>T; p.S357L; 2:43224734-43224734 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.305_306insA; p.E103fs*23; 2:43225498-43225499 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.307_308insG; p.E103fs*23; 2:43225496-43225497 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.145_146insG; p.A49fs*35; 2:43225658-43225659 |
large_intestine; caecum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.181_182insT; p.H62fs*22; 2:43225622-43225623 |
oesophagus | carcinoma; squamous_cell_carcinoma | Insertion - Frameshift |
c.503_504insG; p.C168fs*306; 2:43225300-43225301 |
large_intestine; rectum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.907G>T; p.A303S; 2:43224897-43224897 |
liver | carcinoma | Substitution - Missense |
c.907G>T; p.A303S; 2:43224897-43224897 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.899C>G; p.S300C; 2:43224905-43224905 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.711C>G; p.G237G; 2:43225093-43225093 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.511G>T; p.G171C; 2:43225293-43225293 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.382G>A; p.G128S; 2:43225422-43225422 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.544G>A; p.E182K; 2:43225260-43225260 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.775A>G; p.S259G; 2:43225029-43225029 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.1483T>A; p.*495R; 2:43224321-43224321 |
skin | malignant_melanoma | Nonstop extension |
c.381_382delCG; p.N127fs*346; 2:43225422-43225423 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Deletion - Frameshift |
c.21C>T; p.S7S; 2:43226295-43226295 |
breast | carcinoma | Substitution - coding silent |
c.281_282insG; p.P95fs*8; 2:43225522-43225523 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.1463G>T; p.R488L; 2:43224341-43224341 |
ovary | other; neoplasm | Substitution - Missense |
c.482C>G; p.P161R; 2:43225322-43225322 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.372delT; p.F124fs*63; 2:43225432-43225432 |
peritoneum; appendix | other; pseudomyxoma_peritonei | Deletion - Frameshift |
c.469G>C; p.E157Q; 2:43225335-43225335 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.773T>C; p.L258P; 2:43225031-43225031 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.378G>A; p.E126E; 2:43225426-43225426 |
ovary | other; neoplasm | Substitution - coding silent |
c.442C>T; p.Q148*; 2:43225362-43225362 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.677C>T; p.S226L; 2:43225127-43225127 |
skin | malignant_melanoma | Substitution - Missense |
c.203C>T; p.A68V; 2:43225601-43225601 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.600_601insT; p.H201fs*273; 2:43225203-43225204 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.670G>A; p.A224T; 2:43225134-43225134 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.670G>A; p.A224T; 2:43225134-43225134 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.820C>T; p.L274F; 2:43224984-43224984 |
thyroid | carcinoma | Substitution - Missense |
c.1450C>T; p.P484S; 2:43224354-43224354 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.683_684insG; p.A229fs*245; 2:43225120-43225121 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.683delG; p.G228fs*233; 2:43225121-43225121 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.503G>A; p.C168Y; 2:43225301-43225301 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.410_411insT; p.Q138fs*336; 2:43225393-43225394 |
large_intestine; caecum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.5C>G; p.S2W; 2:43226311-43226311 |
breast | carcinoma | Substitution - Missense |
c.478_479insC; p.R160fs*314; 2:43225325-43225326 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.478_479insC; p.R160fs*314; 2:43225325-43225326 |
large_intestine; rectum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.88A>G; p.M30V; 2:43225716-43225716 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.478_479insC; p.R160fs*314; 2:43225325-43225326 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.464A>G; p.K155R; 2:43225340-43225340 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.464A>G; p.K155R; 2:43225340-43225340 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.465G>C; p.K155N; 2:43225339-43225339 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.465G>C; p.K155N; 2:43225339-43225339 |
breast | carcinoma; basal_(triple-negative)_carcinoma | Substitution - Missense |
c.760T>G; p.L254V; 2:43225044-43225044 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.453delC; p.T152fs*35; 2:43225351-43225351 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1389C>T; p.S463S; 2:43224415-43224415 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.469G>A; p.E157K; 2:43225335-43225335 |
breast | carcinoma | Substitution - Missense |
c.469G>A; p.E157K; 2:43225335-43225335 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.632G>A; p.R211H; 2:43225172-43225172 |
kidney | other; neoplasm | Substitution - Missense |
c.632G>A; p.R211H; 2:43225172-43225172 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.473T>C; p.L158P; 2:43225331-43225331 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.434_435insG; p.G146fs*328; 2:43225369-43225370 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.1433A>C; p.D478A; 2:43224371-43224371 |
pancreas | carcinoma | Substitution - Missense |
c.1349delC; p.P450fs*11; 2:43224455-43224455 |
oesophagus | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.484_485insCGGCCCT; p.F162fs*314; 2:43225319-43225320 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.1042delG; p.A348fs*113; 2:43224762-43224762 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.46T>G; p.C16G; 2:43226270-43226270 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1120_1121insA; p.T374fs*100; 2:43224683-43224684 |
large_intestine; rectum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.718G>A; p.D240N; 2:43225086-43225086 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.718G>A; p.D240N; 2:43225086-43225086 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.514G>T; p.E172*; 2:43225290-43225290 |
skin | malignant_melanoma | Substitution - Nonsense |
c.264C>T; p.G88G; 2:43225540-43225540 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.432_433insG; p.G146fs*328; 2:43225371-43225372 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Insertion - Frameshift |
c.432_433insG; p.G146fs*328; 2:43225371-43225372 |
stomach | carcinoma; intestinal_adenocarcinoma | Insertion - Frameshift |
c.336_337insCT; p.N114fs*74; 2:43225467-43225468 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_leukaemia | Insertion - Frameshift |
c.376G>C; p.E126Q; 2:43225428-43225428 |
breast | carcinoma | Substitution - Missense |
c.54A>T; p.T18T; 2:43225750-43225750 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1125G>C; p.P375P; 2:43224679-43224679 |
upper_aerodigestive_tract; larynx | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.462C>A; p.Y154*; 2:43225342-43225342 |
pancreas | carcinoma | Substitution - Nonsense |
c.431delG; p.G144fs*43; 2:43225373-43225373 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.431delG; p.G144fs*43; 2:43225373-43225373 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.431delG; p.G144fs*43; 2:43225373-43225373 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.431delG; p.G144fs*43; 2:43225373-43225373 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.431delG; p.G144fs*43; 2:43225373-43225373 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.431delG; p.G144fs*43; 2:43225373-43225373 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.832C>T; p.L278L; 2:43224972-43224972 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1375T>C; p.Y459H; 2:43224429-43224429 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.198_208del11; p.H66fs*14; 2:43225596-43225606 |
peritoneum; appendix | other; pseudomyxoma_peritonei | Deletion - Frameshift |
c.320delG; p.G107fs*80; 2:43225484-43225484 |
large_intestine; rectum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.320delG; p.G107fs*80; 2:43225484-43225484 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.320delG; p.G107fs*80; 2:43225484-43225484 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.320delG; p.G107fs*80; 2:43225484-43225484 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.320delG; p.G107fs*80; 2:43225484-43225484 |
large_intestine; caecum | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.361_362insG; p.D121fs*5; 2:43225442-43225443 |
large_intestine; rectum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.920C>T; p.S307F; 2:43224884-43224884 |
skin | malignant_melanoma | Substitution - Missense |
c.622T>G; p.Y208D; 2:43225182-43225182 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.622T>G; p.Y208D; 2:43225182-43225182 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.429G>C; p.G143G; 2:43225375-43225375 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - coding silent |
c.24C>A; p.A8A; 2:43226292-43226292 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1022_1047del26; p.E341fs*124; 2:43224757-43224782 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.298A>G; p.T100A; 2:43225506-43225506 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.73C>T; p.L25F; 2:43225731-43225731 |
breast | carcinoma | Substitution - Missense |
c.602A>C; p.H201P; 2:43225202-43225202 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.945C>T; p.P315P; 2:43224859-43224859 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Substitution - coding silent |
c.118delG; p.V40fs*147; 2:43225686-43225686 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.114_115insGGACG; p.P39fs*150; 2:43225689-43225690 |
endometrium | carcinoma; endometrioid_carcinoma | Insertion - Frameshift |
c.760T>C; p.L254L; 2:43225044-43225044 |
breast | carcinoma | Substitution - coding silent |
c.760T>C; p.L254L; 2:43225044-43225044 |
breast | carcinoma | Substitution - coding silent |
c.447_448insC; p.N150fs*324; 2:43225356-43225357 |
endometrium | carcinoma; endometrioid_carcinoma | Insertion - Frameshift |
c.406_407insC; p.H136fs*338; 2:43225397-43225398 |
large_intestine; rectum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.451_452insA; p.S151fs*323; 2:43225352-43225353 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.321C>G; p.G107G; 2:43225483-43225483 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.533A>T; p.H178L; 2:43225271-43225271 |
oesophagus | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.320_321insG; p.G108fs*18; 2:43225483-43225484 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.320_321insG; p.G108fs*18; 2:43225483-43225484 |
large_intestine; caecum | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.320_321insG; p.G108fs*18; 2:43225483-43225484 |
autonomic_ganglia | neuroblastoma | Insertion - Frameshift |
c.320_321insG; p.G108fs*18; 2:43225483-43225484 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.745G>C; p.E249Q; 2:43225059-43225059 |
urinary_tract; bladder | carcinoma | Substitution - Missense |