Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6997

Name

TDGF1

Synonymous

teratocarcinoma-derived growth factor 1;TDGF1;teratocarcinoma-derived growth factor 1

Definition

cripto-1 growth factor|epidermal growth factor-like cripto protein CR1

Position

3p21.31

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.09.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.162G>A; p.Q54Q; 3:46579305-46579305

 skinmalignant_melanomaSubstitution - coding silent

c.292C>A; p.P98T; 3:46579807-46579807

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.321G>A; p.E107E; 3:46579836-46579836

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.77G>C; p.G26A; 3:46579136-46579136

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.75G>A; p.L25L; 3:46579134-46579134

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.75G>A; p.L25L; 3:46579134-46579134

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.77G>A; p.G26E; 3:46579136-46579136

 breastcarcinomaSubstitution - Missense

c.355C>T; p.P119S; 3:46579967-46579967

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.66C>A; p.V22V; 3:46579125-46579125

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.496C>T; p.L166L; 3:46581179-46581179

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.122G>A; p.R41Q; 3:46579265-46579265

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.291C>A; p.C97*; 3:46579806-46579806

 ovarycarcinoma; serous_carcinomaSubstitution - Nonsense

c.263C>A; p.T88N; 3:46579778-46579778

 prostateadenomaSubstitution - Missense

c.260G>A; p.G87E; 3:46579775-46579775

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.256G>T; p.G86W; 3:46579771-46579771

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.39G>A; p.V13V; 3:46579098-46579098

 skinmalignant_melanomaSubstitution - coding silent

c.406G>A; p.G136S; 3:46580018-46580018

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.560A>G; p.Y187C; 3:46581243-46581243

 skinmalignant_melanomaSubstitution - Missense

c.442G>A; p.G148S; 3:46580054-46580054

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.274G>A; p.G92R; 3:46579789-46579789

 skinmalignant_melanomaSubstitution - Missense

c.125G>A; p.G42E; 3:46579268-46579268

 skinmalignant_melanomaSubstitution - Missense

c.89-1G>A; p.?; 3:46579231-46579231

 skinmalignant_melanomaUnknown

c.191C>T; p.S64F; 3:46579334-46579334

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.312G>A; p.R104R; 3:46579827-46579827

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.312G>A; p.R104R; 3:46579827-46579827

 skinmalignant_melanomaSubstitution - coding silent

c.361G>C; p.D121H; 3:46579973-46579973

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.49A>G; p.M17V; 3:46579108-46579108

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.259G>A; p.G87R; 3:46579774-46579774

 skinmalignant_melanomaSubstitution - Missense

c.278C>T; p.S93F; 3:46579793-46579793

 skinmalignant_melanomaSubstitution - Missense

c.528G>T; p.M176I; 3:46581211-46581211

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.350C>A; p.S117Y; 3:46579962-46579962

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.52G>A; p.A18T; 3:46579111-46579111

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.70G>A; p.E24K; 3:46579129-46579129

 skinmalignant_melanomaSubstitution - Missense

c.65T>C; p.V22A; 3:46579124-46579124

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.36-1G>C; p.?; 3:46579094-46579094

 lungcarcinoma; adenocarcinomaUnknown

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