Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7071

Name

KLF10

Synonymous

Kruppel-like factor 10;KLF10;Kruppel-like factor 10

Definition

Krueppel-like factor 10|TGFB-inducible early growth response protein 1|early growth response-alpha|transforming growth factor-beta-inducible early growth response protein 1|zinc finger transcription factor TIEG

Position

8q22.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.02.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.239G>T; p.G80V; 8:102652195-102652195

 livercarcinomaSubstitution - Missense

c.1004G>A; p.S335N; 8:102651328-102651328

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.284C>A; p.P95H; 8:102652048-102652048

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.383C>T; p.P128L; 8:102651949-102651949

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.271-2A>T; p.?; 8:102652063-102652063

 prostatecarcinoma; adenocarcinomaUnknown

c.385C>T; p.H129Y; 8:102651947-102651947

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.713C>T; p.T238M; 8:102651619-102651619

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.713C>T; p.T238M; 8:102651619-102651619

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1008G>A; p.P336P; 8:102651324-102651324

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.1008G>A; p.P336P; 8:102651324-102651324

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.339G>A; p.A113A; 8:102651993-102651993

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.656A>C; p.D219A; 8:102651676-102651676

 livercarcinomaSubstitution - Missense

c.656A>C; p.D219A; 8:102651676-102651676

 livercarcinomaSubstitution - Missense

c.551C>A; p.S184Y; 8:102651781-102651781

 breastcarcinomaSubstitution - Missense

c.441C>T; p.L147L; 8:102651891-102651891

 skinmalignant_melanomaSubstitution - coding silent

c.551C>A; p.S184Y; 8:102651781-102651781

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1348C>T; p.R450C; 8:102650227-102650227

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1005C>T; p.S335S; 8:102651327-102651327

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.338C>T; p.A113V; 8:102651994-102651994

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1124G>A; p.G375E; 8:102651208-102651208

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.39G>C; p.E13D; 8:102652395-102652395

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.99T>G; p.T33T; 8:102652335-102652335

 ovaryother; neoplasmSubstitution - coding silent

c.1190A>C; p.K397T; 8:102650385-102650385

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.18C>A; p.A6A; 8:102655584-102655584

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.972C>T; p.P324P; 8:102651360-102651360

 skinmalignant_melanomaSubstitution - coding silent

c.958G>A; p.V320M; 8:102651374-102651374

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.808A>G; p.M270V; 8:102651524-102651524

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1176G>A; p.T392T; 8:102651156-102651156

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.337G>T; p.A113S; 8:102651995-102651995

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.484G>A; p.A162T; 8:102651848-102651848

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.178G>C; p.V60L; 8:102652256-102652256

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.992C>T; p.P331L; 8:102651340-102651340

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.123T>C; p.A41A; 8:102652311-102652311

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.994C>G; p.P332A; 8:102651338-102651338

 livercarcinomaSubstitution - Missense

c.744G>A; p.V248V; 8:102651588-102651588

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.994C>G; p.P332A; 8:102651338-102651338

 livercarcinomaSubstitution - Missense

c.45A>G; p.R15R; 8:102652389-102652389

 pancreascarcinomaSubstitution - coding silent

c.1027C>T; p.P343S; 8:102651305-102651305

 skinmalignant_melanomaSubstitution - Missense

c.775C>A; p.P259T; 8:102651557-102651557

 livercarcinomaSubstitution - Missense

c.775C>A; p.P259T; 8:102651557-102651557

 livercarcinomaSubstitution - Missense

c.775C>A; p.P259T; 8:102651557-102651557

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.469C>T; p.R157C; 8:102651863-102651863

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1055C>T; p.P352L; 8:102651277-102651277

 skinmalignant_melanomaSubstitution - Missense

c.373A>G; p.T125A; 8:102651959-102651959

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.35C>T; p.A12V; 8:102655567-102655567

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1343C>T; p.A448V; 8:102650232-102650232

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1343C>T; p.A448V; 8:102650232-102650232

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1076C>T; p.P359L; 8:102651256-102651256

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.240A>G; p.G80G; 8:102652194-102652194

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.22C>G; p.L8V; 8:102655580-102655580

 breastcarcinomaSubstitution - Missense

c.296C>T; p.S99F; 8:102652036-102652036

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.296C>T; p.S99F; 8:102652036-102652036

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.835C>T; p.L279F; 8:102651497-102651497

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.951C>T; p.V317V; 8:102651381-102651381

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.227A>T; p.N76I; 8:102652207-102652207

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1306C>T; p.R436W; 8:102650269-102650269

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1347G>A; p.R449R; 8:102650228-102650228

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.833C>T; p.P278L; 8:102651499-102651499

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1394G>T; p.S465I; 8:102650181-102650181

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.911delC; p.P304fs*31; 8:102651421-102651421

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.25C>T; p.Q9*; 8:102655577-102655577

 haematopoietic_and_lymphoid_tissue; central_nervous_systemlymphoid_neoplasm; primary_central_nervous_system_lymphomaSubstitution - Nonsense

c.532C>A; p.L178I; 8:102651800-102651800

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.531C>A; p.I177I; 8:102651801-102651801

 breastcarcinomaSubstitution - coding silent

c.805C>T; p.P269S; 8:102651527-102651527

 prostatecarcinomaSubstitution - Missense

c.478G>T; p.A160S; 8:102651854-102651854

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1176G>C; p.T392T; 8:102651156-102651156

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.970C>G; p.P324A; 8:102651362-102651362

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.609C>T; p.A203A; 8:102651723-102651723

 prostatecarcinomaSubstitution - coding silent

c.1289C>T; p.A430V; 8:102650286-102650286

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1289C>T; p.A430V; 8:102650286-102650286

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1013G>A; p.G338D; 8:102651319-102651319

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.742G>A; p.V248M; 8:102651590-102651590

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.343T>G; p.S115A; 8:102651989-102651989

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.580G>A; p.E194K; 8:102651752-102651752

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1069G>A; p.V357I; 8:102651263-102651263

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1271C>T; p.T424M; 8:102650304-102650304

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.484G>T; p.A162S; 8:102651848-102651848

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.891G>A; p.Q297Q; 8:102651441-102651441

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.674G>T; p.S225I; 8:102651658-102651658

 livercarcinomaSubstitution - Missense

c.607G>A; p.A203T; 8:102651725-102651725

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.674G>T; p.S225I; 8:102651658-102651658

 livercarcinomaSubstitution - Missense

c.832C>T; p.P278S; 8:102651500-102651500

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.986C>T; p.S329L; 8:102651346-102651346

 skinmalignant_melanomaSubstitution - Missense

c.112G>A; p.D38N; 8:102652322-102652322

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1238C>T; p.S413F; 8:102650337-102650337

 skinmalignant_melanomaSubstitution - Missense

c.506C>G; p.T169S; 8:102651826-102651826

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.986C>A; p.S329*; 8:102651346-102651346

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.986C>A; p.S329*; 8:102651346-102651346

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

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