Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7474

Name

WNT5A

Synonymous

wingless-type MMTV integration site family, member 5A;WNT5A;wingless-type MMTV integration site family, member 5A

Definition

WNT-5A protein|protein Wnt-5a

Position

3p21-p14

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.06.

The copy number variations for various cancers

Top

There is no record for WNT5A

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1311C>T; p.Y437Y; 3:55470203-55470203

oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1372G>C; p.V458L; 3:55470142-55470142

urinary_tract; bladdercarcinomaSubstitution - Missense

c.507T>A; p.S169S; 3:55479477-55479477

oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.447G>A; p.Q149Q; 3:55479537-55479537

breastcarcinomaSubstitution - coding silent

c.421T>C; p.S141P; 3:55479563-55479563

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.883C>T; p.R295W; 3:55474417-55474417

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1398C>T; p.I466I; 3:55470116-55470116

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1229C>T; p.S410L; 3:55470285-55470285

skinmalignant_melanomaSubstitution - Missense

c.1229C>T; p.S410L; 3:55470285-55470285

skinmalignant_melanomaSubstitution - Missense

c.562G>A; p.E188K; 3:55479422-55479422

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.909C>A; p.S303S; 3:55474391-55474391

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1211G>A; p.R404H; 3:55470303-55470303

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.647T>G; p.V216G; 3:55479337-55479337

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.954C>T; p.A318A; 3:55474346-55474346

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.445C>T; p.Q149*; 3:55479539-55479539

breastcarcinoma; HER-positive_carcinomaSubstitution - Nonsense

c.905G>A; p.G302D; 3:55474395-55474395

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.829G>A; p.D277N; 3:55474471-55474471

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.959G>A; p.R320H; 3:55474341-55474341

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1280G>A; p.G427D; 3:55470234-55470234

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.545A>T; p.H182L; 3:55479439-55479439

livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.745G>A; p.E249K; 3:55474555-55474555

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.325A>T; p.M109L; 3:55480879-55480879

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.420-7_420-6insC; p.?; 3:55479570-55479571

thyroidcarcinoma; anaplastic_carcinomaUnknown

c.1186G>A; p.D396N; 3:55470328-55470328

oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1285G>A; p.E429K; 3:55470229-55470229

skinmalignant_melanomaSubstitution - Missense

c.1285G>A; p.E429K; 3:55470229-55470229

skinmalignant_melanomaSubstitution - Missense

c.1244G>A; p.G415D; 3:55470270-55470270

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1244G>A; p.G415D; 3:55470270-55470270

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1206C>G; p.C402W; 3:55470308-55470308

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1121G>A; p.R374Q; 3:55470393-55470393

prostatecarcinomaSubstitution - Missense

c.1401G>A; p.V467V; 3:55470113-55470113

skinmalignant_melanomaSubstitution - coding silent

c.1299C>T; p.C433C; 3:55470215-55470215

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1225G>A; p.G409S; 3:55470289-55470289

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.956G>A; p.G319D; 3:55474344-55474344

prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.422C>T; p.S141L; 3:55479562-55479562

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.850C>T; p.R284C; 3:55474450-55474450

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1137G>T; p.Q379H; 3:55470377-55470377

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1363T>C; p.C455R; 3:55470151-55470151

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.504T>G; p.L168L; 3:55479480-55479480

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.568G>A; p.A190T; 3:55479416-55479416

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1000C>T; p.H334Y; 3:55470514-55470514

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.507_508delTC; p.Q170fs*43; 3:55479476-55479477

endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.586G>T; p.E196*; 3:55479398-55479398

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1127A>G; p.K376R; 3:55470387-55470387

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.570G>A; p.A190A; 3:55479414-55479414

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.591C>T; p.C197C; 3:55479393-55479393

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1340G>A; p.R447H; 3:55470174-55470174

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1238C>T; p.T413M; 3:55470276-55470276

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.969G>A; p.V323V; 3:55470545-55470545

oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1206C>T; p.C402C; 3:55470308-55470308

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1206C>T; p.C402C; 3:55470308-55470308

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.286-2A>G; p.?; 3:55480920-55480920

large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.358C>T; p.L120L; 3:55480846-55480846

breastcarcinomaSubstitution - coding silent

c.1218G>A; p.E406E; 3:55470296-55470296

ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.801G>A; p.P267P; 3:55474499-55474499

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.804G>A; p.R268R; 3:55474496-55474496

skinmalignant_melanomaSubstitution - coding silent

c.804G>A; p.R268R; 3:55474496-55474496

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.874G>A; p.A292T; 3:55474426-55474426

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.874G>A; p.A292T; 3:55474426-55474426

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1235G>A; p.G412D; 3:55470279-55470279

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.618G>A; p.W206*; 3:55479366-55479366

large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1207G>A; p.V403M; 3:55470307-55470307

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1207G>A; p.V403M; 3:55470307-55470307

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1224C>T; p.T408T; 3:55470290-55470290

oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.616T>C; p.W206R; 3:55479368-55479368

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.407C>T; p.A136V; 3:55480797-55480797

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.867C>T; p.F289F; 3:55474433-55474433

skinmalignant_melanomaSubstitution - coding silent

c.489C>A; p.S163R; 3:55479495-55479495

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1057C>T; p.R353C; 3:55470457-55470457

oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1120C>T; p.R374W; 3:55470394-55470394

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.884G>A; p.R295Q; 3:55474416-55474416

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.884G>A; p.R295Q; 3:55474416-55474416

oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.922C>A; p.R308S; 3:55474378-55474378

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.423G>A; p.S141S; 3:55479561-55479561

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.423G>A; p.S141S; 3:55479561-55479561

upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1312G>A; p.D438N; 3:55470202-55470202

skinmalignant_melanomaSubstitution - Missense

c.364G>T; p.A122S; 3:55480840-55480840

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1109_1110GG>TT; p.R370L; 3:55470404-55470405

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.890G>A; p.R297H; 3:55474410-55474410

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1392G>A; p.T464T; 3:55470122-55470122

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1392G>A; p.T464T; 3:55470122-55470122

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.593A>G; p.Q198R; 3:55479391-55479391

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.887A>G; p.E296G; 3:55474413-55474413

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.585A>C; p.K195N; 3:55479399-55479399

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1296C>T; p.C432C; 3:55470218-55470218

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1074C>G; p.A358A; 3:55470440-55470440

prostatecarcinomaSubstitution - coding silent

c.1211G>T; p.R404L; 3:55470303-55470303

oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.783G>A; p.A261A; 3:55474517-55474517

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent


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