Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7481

Name

WNT11

Synonymous

wingless-type MMTV integration site family, member 11;WNT11;wingless-type MMTV integration site family, member 11

Definition

protein Wnt-11

Position

11q13.5

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.06.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.924C>T; p.S308S; 11:76187206-76187206

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.783G>T; p.K261N; 11:76191671-76191671

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.361G>A; p.A121T; 11:76194803-76194803

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.255C>G; p.A85A; 11:76196547-76196547

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.748C>T; p.R250*; 11:76191706-76191706

 skinmalignant_melanomaSubstitution - Nonsense

c.1028G>T; p.R343M; 11:76187102-76187102

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.888C>T; p.D296D; 11:76191566-76191566

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - coding silent

c.380C>T; p.A127V; 11:76194784-76194784

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.967G>T; p.D323Y; 11:76187163-76187163

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.725T>G; p.L242R; 11:76191729-76191729

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.782A>C; p.K261T; 11:76191672-76191672

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.421G>A; p.G141S; 11:76194743-76194743

 pancreascarcinomaSubstitution - Missense

c.1059C>T; p.C353C; 11:76187071-76187071

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.236C>A; p.A79D; 11:76196566-76196566

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.505delG; p.A169fs*8; 11:76194659-76194659

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.236C>A; p.A79D; 11:76196566-76196566

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.126G>A; p.T42T; 11:76196676-76196676

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.443C>A; p.P148H; 11:76194721-76194721

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.29delC; p.A10fs*30; 11:76206379-76206379

 breastcarcinomaDeletion - Frameshift

c.876C>T; p.H292H; 11:76191578-76191578

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.661C>T; p.R221C; 11:76191793-76191793

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.661C>T; p.R221C; 11:76191793-76191793

 breastcarcinomaSubstitution - Missense

c.661C>T; p.R221C; 11:76191793-76191793

 central_nervous_system; braingliomaSubstitution - Missense

c.661C>T; p.R221C; 11:76191793-76191793

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.256G>A; p.D86N; 11:76196546-76196546

 stomachcarcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableSubstitution - Missense

c.256G>A; p.D86N; 11:76196546-76196546

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.648C>T; p.G216G; 11:76191806-76191806

 skinmalignant_melanomaSubstitution - coding silent

c.541_542insA; p.T181fs*7; 11:76194622-76194623

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.541_542insA; p.T181fs*7; 11:76194622-76194623

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.262C>T; p.R88C; 11:76196540-76196540

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1031G>A; p.C344Y; 11:76187099-76187099

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1031G>A; p.C344Y; 11:76187099-76187099

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.709C>G; p.L237V; 11:76191745-76191745

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1018A>C; p.T340P; 11:76187112-76187112

 breastcarcinomaSubstitution - Missense

c.408C>T; p.P136P; 11:76194756-76194756

 thyroidother; neoplasmSubstitution - coding silent

c.408C>T; p.P136P; 11:76194756-76194756

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1031G>T; p.C344F; 11:76187099-76187099

 central_nervous_system; braingliomaSubstitution - Missense

c.221G>A; p.R74H; 11:76196581-76196581

 pituitary; craniopharyngeal_ductcraniopharyngioma; papillarySubstitution - Missense

c.660C>T; p.I220I; 11:76191794-76191794

 skinmalignant_melanomaSubstitution - coding silent

c.719G>A; p.R240Q; 11:76191735-76191735

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.605G>A; p.R202H; 11:76191849-76191849

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.912C>A; p.N304K; 11:76187218-76187218

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - Missense

c.1041C>T; p.T347T; 11:76187089-76187089

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.912C>A; p.N304K; 11:76187218-76187218

 soft_tissue; striated_musclerhabdomyosarcomaSubstitution - Missense

c.743T>C; p.V248A; 11:76191711-76191711

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.928G>A; p.D310N; 11:76187202-76187202

 skinmalignant_melanomaSubstitution - Missense

c.928G>A; p.D310N; 11:76187202-76187202

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.729G>A; p.S243S; 11:76191725-76191725

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1029G>A; p.R343R; 11:76187101-76187101

 skinmalignant_melanomaSubstitution - coding silent

c.197T>C; p.M66T; 11:76196605-76196605

 prostatecarcinomaSubstitution - Missense

c.911A>G; p.N304S; 11:76187219-76187219

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.606C>T; p.R202R; 11:76191848-76191848

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.835T>A; p.S279T; 11:76191619-76191619

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.179G>A; p.R60H; 11:76196623-76196623

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.957C>A; p.N319K; 11:76187173-76187173

 prostateadenomaSubstitution - Missense

c.943G>T; p.G315W; 11:76187187-76187187

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.607G>A; p.A203T; 11:76191847-76191847

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.943G>A; p.G315R; 11:76187187-76187187

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.962A>G; p.Y321C; 11:76187168-76187168

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.621G>A; p.M207I; 11:76191833-76191833

 skinmalignant_melanomaSubstitution - Missense

c.914G>A; p.G305E; 11:76187216-76187216

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.621G>A; p.M207I; 11:76191833-76191833

 skinmalignant_melanomaSubstitution - Missense

c.476A>G; p.D159G; 11:76194688-76194688

 skinmalignant_melanomaSubstitution - Missense

c.909C>T; p.S303S; 11:76187221-76187221

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.84G>A; p.L28L; 11:76196718-76196718

 livercarcinomaSubstitution - coding silent

c.1024C>T; p.R342C; 11:76187106-76187106

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1056C>G; p.V352V; 11:76187074-76187074

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.666C>T; p.T222T; 11:76191788-76191788

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.797G>T; p.R266L; 11:76191657-76191657

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.628A>G; p.K210E; 11:76191826-76191826

 large_intestine; coloncarcinomaSubstitution - Missense

c.628A>G; p.K210E; 11:76191826-76191826

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.956A>G; p.N319S; 11:76187174-76187174

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.1044G>A; p.V348V; 11:76187086-76187086

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.749G>A; p.R250Q; 11:76191705-76191705

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.223G>A; p.E75K; 11:76196579-76196579

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.223G>A; p.E75K; 11:76196579-76196579

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.223G>A; p.E75K; 11:76196579-76196579

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.125C>T; p.T42M; 11:76196677-76196677

 thyroidcarcinomaSubstitution - Missense

c.752C>T; p.P251L; 11:76191702-76191702

 skinmalignant_melanomaSubstitution - Missense

c.523C>T; p.P175S; 11:76194641-76194641

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.799C>G; p.P267A; 11:76191655-76191655

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.56C>T; p.T19I; 11:76206352-76206352

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.667T>A; p.C223S; 11:76191787-76191787

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1052A>G; p.Y351C; 11:76187078-76187078

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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