Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7739

Name

ZNF185

Synonymous

zinc finger protein 185 (LIM domain);ZNF185;zinc finger protein 185 (LIM domain)

Definition

P1-A|zinc finger protein 185

Position

Xq28

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.12.

The copy number variations for various cancers

Top

There is no record for ZNF185

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.217G>T; p.A73S; 23:152920729-152920729

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.724G>C; p.V242L; 23:152959727-152959727

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.758G>A; p.R253K; 23:152959761-152959761

 breastcarcinomaSubstitution - Missense

c.802A>T; p.T268S; 23:152959805-152959805

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.604G>A; p.A202T; 23:152945373-152945373

 thyroidcarcinoma; anaplastic_carcinomaSubstitution - Missense

c.604G>A; p.A202T; 23:152945373-152945373

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.108G>T; p.R36R; 23:152919079-152919079

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.928A>T; p.T310S; 23:152963873-152963873

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1343A>T; p.Y448F; 23:152970525-152970525

 thyroidcarcinomaSubstitution - Missense

c.998C>T; p.S333F; 23:152963943-152963943

 NSNSSubstitution - Missense

c.875_876delGA; p.S294fs*22; 23:152959878-152959879

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.13+7G>A; p.?; 23:152918180-152918180

 pancreascarcinomaUnknown

c.230C>T; p.A77V; 23:152920742-152920742

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.703A>T; p.T235S; 23:152959706-152959706

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.228C>A; p.I76I; 23:152920740-152920740

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.229G>A; p.A77T; 23:152920741-152920741

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.966T>C; p.I322I; 23:152963911-152963911

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.1268T>G; p.I423S; 23:152970450-152970450

 thyroidother; neoplasmSubstitution - Missense

c.759G>T; p.R253S; 23:152959762-152959762

 livercarcinomaSubstitution - Missense

c.101A>G; p.Q34R; 23:152919072-152919072

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.589G>T; p.D197Y; 23:152945358-152945358

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.571C>T; p.P191S; 23:152945340-152945340

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.227T>C; p.I76T; 23:152920739-152920739

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.659C>A; p.S220Y; 23:152945428-152945428

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.228C>T; p.I76I; 23:152920740-152920740

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1021G>A; p.V341M; 23:152965463-152965463

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1199G>A; p.R400Q; 23:152969423-152969423

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.205C>G; p.Q69E; 23:152920717-152920717

 kidneyother; neoplasmSubstitution - Missense

c.1219C>T; p.L407L; 23:152969443-152969443

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.217G>A; p.A73T; 23:152920729-152920729

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.658T>C; p.S220P; 23:152945427-152945427

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.277C>T; p.Q93*; 23:152922213-152922213

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.74A>T; p.E25V; 23:152919045-152919045

 central_nervous_system; brainglioma; astrocytoma_Grade_IISubstitution - Missense

c.74A>T; p.E25V; 23:152919045-152919045

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.74A>T; p.E25V; 23:152919045-152919045

 livercarcinomaSubstitution - Missense

c.74A>T; p.E25V; 23:152919045-152919045

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.938C>G; p.A313G; 23:152963883-152963883

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.92C>T; p.S31L; 23:152919063-152919063

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1197C>A; p.I399I; 23:152969421-152969421

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.793G>T; p.A265S; 23:152959796-152959796

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.785G>A; p.G262E; 23:152959788-152959788

 skinmalignant_melanomaSubstitution - Missense

c.908C>T; p.S303L; 23:152963853-152963853

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.689G>A; p.G230D; 23:152945458-152945458

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.875G>T; p.R292L; 23:152959878-152959878

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.202A>G; p.T68A; 23:152920714-152920714

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1124A>C; p.K375T; 23:152967205-152967205

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1158-2delA; p.?; 23:152969380-152969380

 oesophaguscarcinoma; adenocarcinomaUnknown

c.938C>T; p.A313V; 23:152963883-152963883

 breastcarcinomaSubstitution - Missense

c.231G>A; p.A77A; 23:152920743-152920743

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1322C>T; p.T441I; 23:152970504-152970504

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.885C>T; p.C295C; 23:152959888-152959888

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.866T>C; p.F289S; 23:152959869-152959869

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.642G>A; p.Q214Q; 23:152945411-152945411

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.55_57delGAG; p.E25delE; 23:152919026-152919028

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaDeletion - In frame

c.55_57delGAG; p.E25delE; 23:152919026-152919028

 large_intestine; rectumcarcinoma; adenocarcinomaDeletion - In frame

c.800C>T; p.P267L; 23:152959803-152959803

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.55_57delGAG; p.E25delE; 23:152919026-152919028

 stomachcarcinoma; diffuse_adenocarcinomaDeletion - In frame

c.55_57delGAG; p.E25delE; 23:152919026-152919028

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.55_57delGAG; p.E25delE; 23:152919026-152919028

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.55_57delGAG; p.E25delE; 23:152919026-152919028

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaDeletion - In frame

c.55_57delGAG; p.E25delE; 23:152919026-152919028

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.1261-2A>G; p.?; 23:152970441-152970441

 ovarycarcinoma; serous_carcinomaUnknown

c.1261-2A>G; p.?; 23:152970441-152970441

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.775G>A; p.G259S; 23:152959778-152959778

 skinmalignant_melanomaSubstitution - Missense

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