Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

78986

Name

DUSP26

Synonymous

dual specificity phosphatase 26 (putative);DUSP26;dual specificity phosphatase 26 (putative)

Definition

MAP kinase phosphatase 8|Novel amplified gene in thyroid anaplastic cancer|dual specificity phosphatase SKRP3|dual specificity protein phosphatase 26|low-molecular-mass dual-specificity phosphatase 4|mitogen-activated protein kinase phosphatase 8|neuroend

Position

8p12

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.04.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.369C>T; p.A123A; 8:33593600-33593600

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.190G>A; p.E64K; 8:33597326-33597326

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.562A>C; p.I188L; 8:33592087-33592087

 skinmalignant_melanomaSubstitution - Missense

c.190G>A; p.E64K; 8:33597326-33597326

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.499C>T; p.L167F; 8:33592150-33592150

 skinmalignant_melanomaSubstitution - Missense

c.436+1G>T; p.?; 8:33593532-33593532

 lungcarcinoma; adenocarcinomaUnknown

c.312G>T; p.E104D; 8:33593657-33593657

 soft_tissue; striated_musclerhabdomyosarcoma; alveolarSubstitution - Missense

c.46C>T; p.R16C; 8:33597470-33597470

 skinmalignant_melanomaSubstitution - Missense

c.558A>G; p.R186R; 8:33592091-33592091

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.80G>A; p.R27Q; 8:33597436-33597436

 skinmalignant_melanomaSubstitution - Missense

c.80G>A; p.R27Q; 8:33597436-33597436

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.239G>C; p.R80P; 8:33593730-33593730

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.414C>T; p.H138H; 8:33593555-33593555

 breastcarcinomaSubstitution - coding silent

c.335G>A; p.R112H; 8:33593634-33593634

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.442A>G; p.I148V; 8:33592207-33592207

 pancreascarcinomaSubstitution - Missense

c.561C>T; p.G187G; 8:33592088-33592088

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.628_629GA>TT; p.E210>?; 8:33592020-33592021

 lungcarcinoma; adenocarcinomaComplex

c.247C>A; p.L83I; 8:33593722-33593722

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.145G>A; p.E49K; 8:33597371-33597371

 skinmalignant_melanomaSubstitution - Missense

c.211C>T; p.L71F; 8:33597305-33597305

 skinmalignant_melanomaSubstitution - Missense

c.309C>T; p.P103P; 8:33593660-33593660

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.261C>A; p.G87G; 8:33593708-33593708

 breastcarcinomaSubstitution - coding silent

c.80G>T; p.R27L; 8:33597436-33597436

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.415C>T; p.R139W; 8:33593554-33593554

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.575G>A; p.R192Q; 8:33592074-33592074

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.100G>A; p.E34K; 8:33597416-33597416

 skinmalignant_melanomaSubstitution - Missense

c.344G>T; p.G115V; 8:33593625-33593625

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.205C>T; p.L69F; 8:33597311-33597311

 skinmalignant_melanomaSubstitution - Missense

c.526G>A; p.V176M; 8:33592123-33592123

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.55C>T; p.R19W; 8:33597461-33597461

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.363G>A; p.S121S; 8:33593606-33593606

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.472C>T; p.R158*; 8:33592177-33592177

 skinmalignant_melanomaSubstitution - Nonsense

c.419C>T; p.A140V; 8:33593550-33593550

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.373G>A; p.D125N; 8:33593596-33593596

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.338A>G; p.Y113C; 8:33593631-33593631

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.441G>T; p.K147N; 8:33592208-33592208

 pancreascarcinomaSubstitution - Missense

c.43G>A; p.A15T; 8:33597473-33597473

 skin; extremitymalignant_melanomaSubstitution - Missense

c.58A>G; p.S20G; 8:33597458-33597458

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.436G>C; p.G146R; 8:33593533-33593533

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.465C>T; p.G155G; 8:33592184-33592184

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.441G>C; p.K147N; 8:33592208-33592208

 breastcarcinomaSubstitution - Missense

c.53C>T; p.S18F; 8:33597463-33597463

 skinmalignant_melanomaSubstitution - Missense

c.221+1G>C; p.?; 8:33597294-33597294

 livercarcinomaUnknown

c.624T>A; p.G208G; 8:33592025-33592025

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.321G>T; p.E107D; 8:33593648-33593648

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.222-2A>T; p.?; 8:33593749-33593749

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.180C>A; p.N60K; 8:33597336-33597336

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.342G>C; p.L114L; 8:33593627-33593627

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.248T>C; p.L83P; 8:33593721-33593721

 NSmalignant_melanomaSubstitution - Missense

c.26C>T; p.A9V; 8:33597490-33597490

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.238C>T; p.R80C; 8:33593731-33593731

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.138C>T; p.F46F; 8:33597378-33597378

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.522C>A; p.T174T; 8:33592127-33592127

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.138C>T; p.F46F; 8:33597378-33597378

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.138C>T; p.F46F; 8:33597378-33597378

 skinmalignant_melanomaSubstitution - coding silent

c.501C>T; p.L167L; 8:33592148-33592148

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.546C>A; p.V182V; 8:33592103-33592103

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.222-1G>A; p.?; 8:33593748-33593748

 skinmalignant_melanomaUnknown

c.403G>T; p.D135Y; 8:33593566-33593566

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.79C>T; p.R27*; 8:33597437-33597437

 lungcarcinoma; small_cell_carcinomaSubstitution - Nonsense

c.244G>A; p.E82K; 8:33593725-33593725

 skinmalignant_melanomaSubstitution - Missense

c.244G>A; p.E82K; 8:33593725-33593725

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.142T>C; p.L48L; 8:33597374-33597374

 skinmalignant_melanomaSubstitution - coding silent

c.164G>T; p.G55V; 8:33597352-33597352

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.91A>G; p.T31A; 8:33597425-33597425

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.487G>A; p.V163I; 8:33592162-33592162

 pancreascarcinomaSubstitution - Missense

c.250C>T; p.R84C; 8:33593719-33593719

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.250C>T; p.R84C; 8:33593719-33593719

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.161C>A; p.T54K; 8:33597355-33597355

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.437-1_437GG>TT; p.?; 8:33592212-33592213

 lungcarcinoma; small_cell_carcinomaUnknown

c.268C>T; p.H90Y; 8:33593701-33593701

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.370T>A; p.F124I; 8:33593599-33593599

 skinmalignant_melanomaSubstitution - Missense

c.325C>G; p.L109V; 8:33593644-33593644

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.583C>T; p.L195L; 8:33592066-33592066

 pancreascarcinomaSubstitution - coding silent

c.281C>T; p.A94V; 8:33593688-33593688

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.73C>T; p.P25S; 8:33597443-33597443

 bone; pelvischondrosarcomaSubstitution - Missense

c.473G>A; p.R158Q; 8:33592176-33592176

 skinmalignant_melanomaSubstitution - Missense

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