Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

79759

Name

ZNF668

Synonymous

zinc finger protein 668;ZNF668;zinc finger protein 668

Definition

-

Position

16p11.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.18.

The copy number variations for various cancers

Top

There is no record for ZNF668

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.857G>C; p.G286A; 16:31062071-31062071

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1806_1814delACCCCTGGA; p.E605_L607delEPL; 16:31061114-31061122

 ovarycarcinoma; serous_carcinomaDeletion - In frame

c.1806_1814delACCCCTGGA; p.E605_L607delEPL; 16:31061114-31061122

 ovarycarcinoma; serous_carcinomaDeletion - In frame

c.149C>G; p.S50C; 16:31064311-31064311

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.39C>T; p.P13P; 16:31064421-31064421

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1543delC; p.Q515fs*14; 16:31061385-31061385

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.680C>T; p.S227F; 16:31062248-31062248

 skinmalignant_melanomaSubstitution - Missense

c.1841C>A; p.P614H; 16:31061087-31061087

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.915G>A; p.V305V; 16:31062013-31062013

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1084C>T; p.R362W; 16:31061844-31061844

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.139G>A; p.A47T; 16:31064321-31064321

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.196G>A; p.A66T; 16:31064264-31064264

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.1344A>C; p.A448A; 16:31061584-31061584

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - coding silent

c.1344A>C; p.A448A; 16:31061584-31061584

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - coding silent

c.1172C>T; p.P391L; 16:31061756-31061756

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.633C>T; p.L211L; 16:31063827-31063827

 skinmalignant_melanomaSubstitution - coding silent

c.1527T>C; p.A509A; 16:31061401-31061401

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.444C>A; p.A148A; 16:31064016-31064016

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1708C>T; p.R570C; 16:31061220-31061220

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.855C>T; p.C285C; 16:31062073-31062073

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1667G>A; p.R556Q; 16:31061261-31061261

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.856G>A; p.G286S; 16:31062072-31062072

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.181G>C; p.E61Q; 16:31064279-31064279

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.1259C>T; p.A420V; 16:31061669-31061669

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1668G>T; p.R556R; 16:31061260-31061260

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1731T>A; p.C577*; 16:31061197-31061197

 pancreascarcinomaSubstitution - Nonsense

c.758G>A; p.R253H; 16:31062170-31062170

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1650C>A; p.G550G; 16:31061278-31061278

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.1650C>A; p.G550G; 16:31061278-31061278

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1633C>T; p.P545S; 16:31061295-31061295

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.407G>T; p.G136V; 16:31064053-31064053

 pancreascarcinomaSubstitution - Missense

c.1115C>T; p.A372V; 16:31061813-31061813

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.137C>T; p.P46L; 16:31064323-31064323

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.1177C>T; p.H393Y; 16:31061751-31061751

 skinmalignant_melanomaSubstitution - Missense

c.786G>A; p.T262T; 16:31062142-31062142

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1438A>G; p.T480A; 16:31061490-31061490

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1517delG; p.G506fs*23; 16:31061411-31061411

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.1517delG; p.G506fs*23; 16:31061411-31061411

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1618G>A; p.E540K; 16:31061310-31061310

 skinmalignant_melanomaSubstitution - Missense

c.568C>T; p.H190Y; 16:31063892-31063892

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1069G>T; p.V357L; 16:31061859-31061859

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.1587G>A; p.T529T; 16:31061341-31061341

 breastcarcinomaSubstitution - coding silent

c.1032G>A; p.T344T; 16:31061896-31061896

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1140G>A; p.T380T; 16:31061788-31061788

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1391C>T; p.P464L; 16:31061537-31061537

 thyroidcarcinomaSubstitution - Missense

c.817A>T; p.T273S; 16:31062111-31062111

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1090T>A; p.F364I; 16:31061838-31061838

 skinmalignant_melanomaSubstitution - Missense

c.408C>T; p.G136G; 16:31064052-31064052

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1491C>T; p.P497P; 16:31061437-31061437

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.259C>T; p.P87S; 16:31064201-31064201

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.761G>A; p.C254Y; 16:31062167-31062167

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.617C>A; p.A206E; 16:31063843-31063843

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.738C>T; p.H246H; 16:31062190-31062190

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1755C>T; p.S585S; 16:31061173-31061173

 pancreascarcinomaSubstitution - coding silent

c.606C>T; p.G202G; 16:31063854-31063854

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1755C>T; p.S585S; 16:31061173-31061173

 prostatecarcinomaSubstitution - coding silent

c.687C>A; p.C229*; 16:31062241-31062241

 ovarycarcinoma; serous_carcinomaSubstitution - Nonsense

c.731G>A; p.R244H; 16:31062197-31062197

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.358C>T; p.R120C; 16:31064102-31064102

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1243C>T; p.R415*; 16:31061685-31061685

 pancreascarcinomaSubstitution - Nonsense

c.1352G>A; p.G451E; 16:31061576-31061576

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.1199C>T; p.S400F; 16:31061729-31061729

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.900C>T; p.R300R; 16:31062028-31062028

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1572C>G; p.T524T; 16:31061356-31061356

 breastcarcinomaSubstitution - coding silent

c.1376T>C; p.L459P; 16:31061552-31061552

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1332C>A; p.A444A; 16:31061596-31061596

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1376T>C; p.L459P; 16:31061552-31061552

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.604G>T; p.G202C; 16:31063856-31063856

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.886C>T; p.R296C; 16:31062042-31062042

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.664C>T; p.R222C; 16:31062264-31062264

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1834G>C; p.G612R; 16:31061094-31061094

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1427T>G; p.V476G; 16:31061501-31061501

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.1427T>G; p.V476G; 16:31061501-31061501

 haematopoietic_and_lymphoid_tissue; central_nervous_systemlymphoid_neoplasm; primary_central_nervous_system_lymphomaSubstitution - Missense

c.1427T>G; p.V476G; 16:31061501-31061501

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.1617G>A; p.P539P; 16:31061311-31061311

 skinmalignant_melanomaSubstitution - coding silent

c.1818C>T; p.P606P; 16:31061110-31061110

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1160C>T; p.S387L; 16:31061768-31061768

 breastcarcinomaSubstitution - Missense

c.1576T>G; p.S526A; 16:31061352-31061352

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.1686C>T; p.H562H; 16:31061242-31061242

 kidneyother; neoplasmSubstitution - coding silent

c.1599G>A; p.R533R; 16:31061329-31061329

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1599G>A; p.R533R; 16:31061329-31061329

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.422G>A; p.R141H; 16:31064038-31064038

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.847C>A; p.P283T; 16:31062081-31062081

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.339G>A; p.P113P; 16:31064121-31064121

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.339G>A; p.P113P; 16:31064121-31064121

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.453G>T; p.A151A; 16:31064007-31064007

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1249A>G; p.S417G; 16:31061679-31061679

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1340C>T; p.A447V; 16:31061588-31061588

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.993A>G; p.T331T; 16:31061935-31061935

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1340C>T; p.A447V; 16:31061588-31061588

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.740C>T; p.A247V; 16:31062188-31062188

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1554C>T; p.C518C; 16:31061374-31061374

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.197C>T; p.A66V; 16:31064263-31064263

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.787C>A; p.Q263K; 16:31062141-31062141

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.409G>C; p.E137Q; 16:31064051-31064051

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1064C>T; p.A355V; 16:31061864-31061864

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1389C>T; p.P463P; 16:31061539-31061539

 livercarcinomaSubstitution - coding silent

c.1627C>A; p.P543T; 16:31061301-31061301

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1389C>T; p.P463P; 16:31061539-31061539

 livercarcinomaSubstitution - coding silent

c.1095C>T; p.R365R; 16:31061833-31061833

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1816C>T; p.P606S; 16:31061112-31061112

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.994G>A; p.G332S; 16:31061934-31061934

 skinmalignant_melanomaSubstitution - Missense

c.994G>A; p.G332S; 16:31061934-31061934

 skinmalignant_melanomaSubstitution - Missense

c.456C>T; p.L152L; 16:31064004-31064004

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.911G>A; p.G304E; 16:31062017-31062017

 skin; upper_legmalignant_melanomaSubstitution - Missense

c.1546T>C; p.F516L; 16:31061382-31061382

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.135G>T; p.G45G; 16:31064325-31064325

 breastcarcinomaSubstitution - coding silent

c.992C>G; p.T331R; 16:31061936-31061936

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.510C>T; p.C170C; 16:31063950-31063950

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1349C>T; p.A450V; 16:31061579-31061579

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1349C>T; p.A450V; 16:31061579-31061579

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1349C>T; p.A450V; 16:31061579-31061579

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.770G>T; p.C257F; 16:31062158-31062158

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1081C>G; p.Q361E; 16:31061847-31061847

 breastcarcinomaSubstitution - Missense

c.675C>G; p.L225L; 16:31062253-31062253

 lungcarcinoma; small_cell_carcinomaSubstitution - coding silent

c.829delG; p.E277fs*29; 16:31062099-31062099

 skin; head_neckcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.1278G>A; p.Q426Q; 16:31061650-31061650

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1292G>A; p.G431E; 16:31061636-31061636

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.1778C>T; p.T593I; 16:31061150-31061150

 skinmalignant_melanomaSubstitution - Missense

c.1709G>A; p.R570H; 16:31061219-31061219

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1817C>T; p.P606L; 16:31061111-31061111

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.101C>T; p.A34V; 16:31064359-31064359

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.617C>T; p.A206V; 16:31063843-31063843

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1543_1544insC; p.Q515fs*41; 16:31061384-31061385

 skinmalignant_melanomaInsertion - Frameshift

c.1543_1544insC; p.Q515fs*41; 16:31061384-31061385

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1543_1544insC; p.Q515fs*41; 16:31061384-31061385

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.1543_1544insC; p.Q515fs*41; 16:31061384-31061385

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.1543_1544insC; p.Q515fs*41; 16:31061384-31061385

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.1312G>A; p.V438M; 16:31061616-31061616

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1312G>A; p.V438M; 16:31061616-31061616

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.871G>A; p.D291N; 16:31062057-31062057

 pancreascarcinomaSubstitution - Missense

c.162C>T; p.A54A; 16:31064298-31064298

 breastcarcinomaSubstitution - coding silent

c.563G>A; p.R188H; 16:31063897-31063897

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.930C>T; p.C310C; 16:31061998-31061998

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.690G>A; p.G230G; 16:31062238-31062238

 breastcarcinomaSubstitution - coding silent

c.83C>T; p.T28I; 16:31064377-31064377

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.83C>T; p.T28I; 16:31064377-31064377

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.354C>T; p.G118G; 16:31064106-31064106

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.689G>T; p.G230V; 16:31062239-31062239

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1666C>A; p.R556R; 16:31061262-31061262

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1666C>A; p.R556R; 16:31061262-31061262

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.453G>A; p.A151A; 16:31064007-31064007

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

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