Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

79791

Name

FBXO31

Synonymous

F-box protein 31;FBXO31;F-box protein 31

Definition

F-box only protein 31|SCF ubiquitin ligase specificity factor|putative breast cancer tumor-suppressor

Position

16q24.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.183G>A; p.T61T; 16:87342910-87342910

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1080G>A; p.K360K; 16:87331312-87331312

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.988G>C; p.E330Q; 16:87331404-87331404

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.23C>T; p.P8L; 16:87343716-87343716

 skinmalignant_melanomaSubstitution - Missense

c.695C>T; p.P232L; 16:87334072-87334072

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.566G>A; p.R189H; 16:87334201-87334201

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.566G>A; p.R189H; 16:87334201-87334201

 skinmalignant_melanomaSubstitution - Missense

c.566G>A; p.R189H; 16:87334201-87334201

 prostatecarcinomaSubstitution - Missense

c.479C>T; p.T160M; 16:87335305-87335305

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.739A>G; p.T247A; 16:87334028-87334028

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.66C>T; p.I22I; 16:87343673-87343673

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.585C>A; p.S195S; 16:87334182-87334182

 kidneyother; neoplasmSubstitution - coding silent

c.223C>T; p.R75W; 16:87336258-87336258

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.536G>A; p.R179Q; 16:87334231-87334231

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.376G>A; p.D126N; 16:87335408-87335408

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.755G>A; p.G252D; 16:87334012-87334012

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.30C>T; p.V10V; 16:87343709-87343709

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.637G>A; p.G213R; 16:87334130-87334130

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.466G>A; p.G156S; 16:87335318-87335318

 thyroidcarcinoma; medullary_carcinomaSubstitution - Missense

c.305T>C; p.F102S; 16:87336176-87336176

 breastcarcinomaSubstitution - Missense

c.606C>T; p.R202R; 16:87334161-87334161

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.694C>T; p.P232S; 16:87334073-87334073

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.201C>T; p.S67S; 16:87342892-87342892

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.246G>A; p.W82*; 16:87336235-87336235

 skin; extremitymalignant_melanomaSubstitution - Nonsense

c.829C>T; p.P277S; 16:87333938-87333938

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.829C>T; p.P277S; 16:87333938-87333938

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.46T>C; p.F16L; 16:87343693-87343693

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.594C>T; p.V198V; 16:87334173-87334173

 skinmalignant_melanomaSubstitution - coding silent

c.1100_1102delCCT; p.S367delS; 16:87331290-87331292

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.535C>G; p.R179G; 16:87334232-87334232

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.834G>T; p.V278V; 16:87333933-87333933

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1050G>A; p.P350P; 16:87331342-87331342

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.416G>A; p.S139N; 16:87335368-87335368

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.676C>G; p.R226G; 16:87334091-87334091

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.802T>C; p.C268R; 16:87333965-87333965

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.298A>T; p.M100L; 16:87336183-87336183

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.424C>A; p.L142M; 16:87335360-87335360

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1025C>T; p.A342V; 16:87331367-87331367

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.298A>T; p.M100L; 16:87336183-87336183

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1092C>T; p.S364S; 16:87331300-87331300

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.1092C>T; p.S364S; 16:87331300-87331300

 skinmalignant_melanomaSubstitution - coding silent

c.457C>T; p.R153C; 16:87335327-87335327

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1093C>T; p.L365F; 16:87331299-87331299

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.535C>T; p.R179W; 16:87334232-87334232

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.535C>T; p.R179W; 16:87334232-87334232

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.347G>A; p.R116H; 16:87335437-87335437

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.28G>A; p.V10I; 16:87343711-87343711

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.265A>C; p.I89L; 16:87336216-87336216

 thyroidother; neoplasmSubstitution - Missense

c.31G>A; p.D11N; 16:87343708-87343708

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.524A>G; p.D175G; 16:87334243-87334243

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.420C>T; p.H140H; 16:87335364-87335364

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.931C>T; p.R311C; 16:87331461-87331461

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.658C>T; p.R220C; 16:87334109-87334109

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.420C>T; p.H140H; 16:87335364-87335364

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.315C>T; p.T105T; 16:87336166-87336166

 lungcarcinoma; non_small_cell_carcinomaSubstitution - coding silent

c.24C>T; p.P8P; 16:87343715-87343715

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.807G>A; p.G269G; 16:87333960-87333960

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.368G>A; p.R123H; 16:87335416-87335416

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1A>C; p.M1L; 16:87343738-87343738

 skinmalignant_melanomaSubstitution - Missense

c.38C>G; p.P13R; 16:87343701-87343701

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.204C>T; p.G68G; 16:87342889-87342889

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.800A>T; p.Q267L; 16:87333967-87333967

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.589A>G; p.I197V; 16:87334178-87334178

 bone; ribEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.224G>A; p.R75Q; 16:87336257-87336257

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.224G>A; p.R75Q; 16:87336257-87336257

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.442A>G; p.S148G; 16:87335342-87335342

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.346C>T; p.R116C; 16:87335438-87335438

 skinmalignant_melanomaSubstitution - Missense

c.1054C>T; p.P352S; 16:87331338-87331338

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.480+2T>C; p.?; 16:87335302-87335302

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.122C>T; p.P41L; 16:87343617-87343617

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.759C>T; p.G253G; 16:87334008-87334008

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.811G>A; p.G271R; 16:87333956-87333956

 skinmalignant_melanomaSubstitution - Missense

c.77A>G; p.E26G; 16:87343662-87343662

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.109G>A; p.G37S; 16:87343630-87343630

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1039G>A; p.A347T; 16:87331353-87331353

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.960T>C; p.D320D; 16:87331432-87331432

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.913G>A; p.G305S; 16:87331479-87331479

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.605G>A; p.R202H; 16:87334162-87334162

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.367C>T; p.R123C; 16:87335417-87335417

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.450C>T; p.H150H; 16:87335334-87335334

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.604C>T; p.R202C; 16:87334163-87334163

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.822C>T; p.F274F; 16:87333945-87333945

 skinmalignant_melanomaSubstitution - coding silent

c.261G>C; p.E87D; 16:87336220-87336220

 thyroidother; neoplasmSubstitution - Missense

c.848G>A; p.R283K; 16:87333919-87333919

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.67C>T; p.H23Y; 16:87343672-87343672

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.972C>T; p.F324F; 16:87331420-87331420

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.228G>A; p.T76T; 16:87336253-87336253

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

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