Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7982

Name

ST7

Synonymous

suppression of tumorigenicity 7;ST7;suppression of tumorigenicity 7

Definition

family with sequence similarity 4, subfamily A, member 1|suppression of tumorigenicity 7 (breast)|suppressor of tumorigenicity 7 protein

Position

7q31.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.16.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1436A>G; p.K479R; 7:117219114-117219114

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1078+7T>C; p.?; 7:117170983-117170983

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.280G>A; p.E94K; 7:117119606-117119606

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.163T>C; p.L55L; 7:117099773-117099773

 skinmalignant_melanomaSubstitution - coding silent

c.1285delC; p.P430fs*5; 7:117209817-117209817

 breastcarcinomaDeletion - Frameshift

c.979C>T; p.P327S; 7:117170877-117170877

 livercarcinomaSubstitution - Missense

c.979C>T; p.P327S; 7:117170877-117170877

 livercarcinomaSubstitution - Missense

c.831_833delACA; p.Q278delQ; 7:117136201-117136203

 endometriumcarcinoma; endometrioid_carcinomaDeletion - In frame

c.1437G>A; p.K479K; 7:117219115-117219115

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.697A>C; p.K233Q; 7:117134179-117134179

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1471G>A; p.E491K; 7:117219149-117219149

 skinmalignant_melanomaSubstitution - Missense

c.1426C>T; p.P476S; 7:117219104-117219104

 skinmalignant_melanomaSubstitution - Missense

c.299A>T; p.H100L; 7:117119625-117119625

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.142T>G; p.L48V; 7:116953682-116953682

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.772A>G; p.K258E; 7:117136142-117136142

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1055A>C; p.Q352P; 7:117170953-117170953

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.981C>T; p.P327P; 7:117170879-117170879

 skinmalignant_melanomaSubstitution - coding silent

c.1380T>C; p.N460N; 7:117209912-117209912

 pancreascarcinomaSubstitution - coding silent

c.87C>T; p.F29F; 7:116953627-116953627

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.306C>T; p.R102R; 7:117119632-117119632

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1737A>G; p.Q579Q; 7:117222959-117222959

 breastcarcinomaSubstitution - coding silent

c.1685A>G; p.K562R; 7:117222907-117222907

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.104T>C; p.V35A; 7:116953644-116953644

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.1695C>T; p.F565F; 7:117222917-117222917

 skinmalignant_melanomaSubstitution - coding silent

c.591delA; p.N198fs*15; 7:117131910-117131910

 kidneycarcinoma; clear_cell_renal_cell_carcinomaDeletion - Frameshift

c.334T>C; p.S112P; 7:117119660-117119660

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.971A>G; p.K324R; 7:117170869-117170869

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.179C>T; p.P60L; 7:117099789-117099789

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.1658C>T; p.S553L; 7:117222880-117222880

 skinmalignant_melanomaSubstitution - Missense

c.1549C>A; p.L517I; 7:117221973-117221973

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.390C>T; p.V130V; 7:117119716-117119716

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1740T>C; p.S580S; 7:117222962-117222962

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.129A>C; p.K43N; 7:116953669-116953669

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1302G>A; p.L434L; 7:117209834-117209834

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.469C>T; p.R157*; 7:117130510-117130510

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1195G>A; p.E399K; 7:117190877-117190877

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1195G>A; p.E399K; 7:117190877-117190877

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1392T>C; p.C464C; 7:117209924-117209924

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1591C>T; p.L531F; 7:117222015-117222015

 skinmalignant_melanomaSubstitution - Missense

c.1281C>G; p.I427M; 7:117209813-117209813

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.556G>A; p.A186T; 7:117130597-117130597

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.556G>A; p.A186T; 7:117130597-117130597

 haematopoietic_and_lymphoid_tissue; central_nervous_systemlymphoid_neoplasm; primary_central_nervous_system_lymphomaSubstitution - Missense

c.556G>A; p.A186T; 7:117130597-117130597

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.36C>T; p.L12L; 7:116953576-116953576

 breastcarcinomaSubstitution - coding silent

c.789C>T; p.A263A; 7:117136159-117136159

 skin; neckmalignant_melanomaSubstitution - coding silent

c.1411C>T; p.R471W; 7:117219089-117219089

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1411C>T; p.R471W; 7:117219089-117219089

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.338C>T; p.S113F; 7:117119664-117119664

 skinmalignant_melanomaSubstitution - Missense

c.784C>T; p.Q262*; 7:117136154-117136154

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1453C>T; p.P485S; 7:117219131-117219131

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1399G>C; p.E467Q; 7:117209931-117209931

 pancreascarcinomaSubstitution - Missense

c.1006G>T; p.E336*; 7:117170904-117170904

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1399G>C; p.E467Q; 7:117209931-117209931

 pancreascarcinomaSubstitution - Missense

c.1399G>C; p.E467Q; 7:117209931-117209931

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.642A>T; p.E214D; 7:117134124-117134124

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.153G>T; p.V51V; 7:117099763-117099763

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1338C>A; p.F446L; 7:117209870-117209870

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.25C>T; p.L9L; 7:116953565-116953565

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.351T>G; p.N117K; 7:117119677-117119677

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.351T>G; p.N117K; 7:117119677-117119677

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1751A>G; p.Q584R; 7:117222973-117222973

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.800G>T; p.G267V; 7:117136170-117136170

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.1541T>G; p.F514C; 7:117221965-117221965

 skinmalignant_melanomaSubstitution - Missense

c.1342C>A; p.H448N; 7:117209874-117209874

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.1310G>T; p.G437V; 7:117209842-117209842

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1589C>T; p.A530V; 7:117222013-117222013

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.716C>T; p.A239V; 7:117136086-117136086

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1681T>C; p.C561R; 7:117222903-117222903

 skinmalignant_melanomaSubstitution - Missense

c.1520A>T; p.Y507F; 7:117221944-117221944

 ovaryother; neoplasmSubstitution - Missense

c.883T>C; p.L295L; 7:117138452-117138452

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.814C>G; p.R272G; 7:117136184-117136184

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1711G>A; p.E571K; 7:117222933-117222933

 breastcarcinomaSubstitution - Missense

c.151+1_151+2insT; p.?; 7:116953692-116953693

 oesophaguscarcinoma; adenocarcinomaUnknown

c.410G>A; p.R137Q; 7:117129808-117129808

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.410G>A; p.R137Q; 7:117129808-117129808

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.410G>A; p.R137Q; 7:117129808-117129808

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.235-2A>G; p.?; 7:117119559-117119559

 central_nervous_system; brainglioma; astrocytoma_Grade_IVUnknown

c.1228G>T; p.V410L; 7:117190910-117190910

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.824A>G; p.Q275R; 7:117136194-117136194

 breastcarcinomaSubstitution - Missense

c.1240C>T; p.P414S; 7:117190922-117190922

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.250_251insT; p.Y84fs*11; 7:117119576-117119577

 central_nervous_system; brainglioma; astrocytoma_Grade_IVInsertion - Frameshift

c.219A>T; p.I73I; 7:117099829-117099829

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.451T>C; p.Y151H; 7:117130492-117130492

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.448C>T; p.R150W; 7:117129846-117129846

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.448C>T; p.R150W; 7:117129846-117129846

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.989G>A; p.S330N; 7:117170887-117170887

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1429T>G; p.L477V; 7:117219107-117219107

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

')