Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

80023

Name

NRSN2

Synonymous

neurensin 2;NRSN2;neurensin 2

Definition

neurensin-2

Position

20p13

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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There is no record for NRSN2

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.487G>A; p.G163R; 20:353507-353507

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.573G>A; p.G191G; 20:353593-353593

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.196C>T; p.L66L; 20:353216-353216

 skinmalignant_melanomaSubstitution - coding silent

c.161G>A; p.R54H; 20:349804-349804

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.161G>A; p.R54H; 20:349804-349804

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.269T>C; p.L90P; 20:353289-353289

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.418G>T; p.G140C; 20:353438-353438

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.269T>C; p.L90P; 20:353289-353289

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1A>G; p.M1V; 20:349644-349644

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.543A>G; p.S181S; 20:353563-353563

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.606G>A; p.R202R; 20:353626-353626

 kidneyother; neoplasmSubstitution - coding silent

c.568T>C; p.F190L; 20:353588-353588

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.207G>A; p.G69G; 20:353227-353227

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.449C>T; p.P150L; 20:353469-353469

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.460G>A; p.E154K; 20:353480-353480

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.265A>G; p.K89E; 20:353285-353285

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.137A>C; p.E46A; 20:349780-349780

 breastcarcinomaSubstitution - Missense

c.507G>A; p.Q169Q; 20:353527-353527

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.587A>G; p.Q196R; 20:353607-353607

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.38G>A; p.R13H; 20:349681-349681

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.433G>A; p.D145N; 20:353453-353453

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.316G>T; p.A106S; 20:353336-353336

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.557C>A; p.P186H; 20:353577-353577

 livercarcinomaSubstitution - Missense

c.557C>A; p.P186H; 20:353577-353577

 livercarcinomaSubstitution - Missense

c.234G>A; p.A78A; 20:353254-353254

 large_intestine; colonadenomaSubstitution - coding silent

c.424C>T; p.L142L; 20:353444-353444

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.8C>T; p.P3L; 20:349651-349651

 livercarcinomaSubstitution - Missense

c.480G>T; p.E160D; 20:353500-353500

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.332C>T; p.A111V; 20:353352-353352

 thyroidcarcinoma; medullary_carcinomaSubstitution - Missense

c.190A>G; p.I64V; 20:353210-353210

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.586C>T; p.Q196*; 20:353606-353606

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.522C>T; p.F174F; 20:353542-353542

 skinmalignant_melanomaSubstitution - coding silent

c.522C>T; p.F174F; 20:353542-353542

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.164G>A; p.R55Q; 20:349807-349807

 breastcarcinomaSubstitution - Missense

c.423G>T; p.W141C; 20:353443-353443

 oesophaguscarcinomaSubstitution - Missense

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