Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

83787

Name

ARMC10

Synonymous

armadillo repeat containing 10;ARMC10;armadillo repeat containing 10

Definition

armadillo repeat-containing protein 10|specific splicing variant involved in hepatocarcinogenesis|splicing variant involved in hepatocarcinogenesis protein

Position

7q22.1

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.04.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.628A>C; p.N210H; 7:103092576-103092576

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.847C>T; p.L283L; 7:103098368-103098368

 skinmalignant_melanomaSubstitution - coding silent

c.1007T>G; p.V336G; 7:103098528-103098528

 skinmalignant_melanomaSubstitution - Missense

c.394-1G>A; p.?; 7:103086629-103086629

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.563C>T; p.S188F; 7:103092511-103092511

 prostatecarcinomaSubstitution - Missense

c.96_97GC>TT; p.R32>?; 7:103075368-103075369

 lungcarcinoma; adenocarcinomaComplex

c.529-1G>T; p.?; 7:103092476-103092476

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.814G>A; p.V272I; 7:103098335-103098335

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.521A>C; p.K174T; 7:103086757-103086757

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.267T>C; p.Y89Y; 7:103083704-103083704

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.346A>G; p.R116G; 7:103083783-103083783

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.702G>A; p.T234T; 7:103092650-103092650

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.702G>A; p.T234T; 7:103092650-103092650

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.811C>T; p.H271Y; 7:103098332-103098332

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.764T>A; p.L255H; 7:103097335-103097335

 central_nervous_system; spinal_cordglioma; ependymomaSubstitution - Missense

c.1030T>C; p.*344R; 7:103098551-103098551

 endometriumcarcinoma; endometrioid_carcinomaNonstop extension

c.580G>T; p.A194S; 7:103092528-103092528

 livercarcinomaSubstitution - Missense

c.938A>G; p.H313R; 7:103098459-103098459

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.154G>T; p.G52W; 7:103075791-103075791

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.869G>A; p.C290Y; 7:103098390-103098390

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1006G>A; p.V336I; 7:103098527-103098527

 skin; solemalignant_melanoma; acral_lentiginousSubstitution - Missense

c.148G>T; p.E50*; 7:103075785-103075785

 skinmalignant_melanomaSubstitution - Nonsense

c.761G>A; p.G254E; 7:103097332-103097332

 central_nervous_system; spinal_cordglioma; ependymomaSubstitution - Missense

c.894T>C; p.A298A; 7:103098415-103098415

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.939T>C; p.H313H; 7:103098460-103098460

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.813C>T; p.H271H; 7:103098334-103098334

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.813C>T; p.H271H; 7:103098334-103098334

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.573G>A; p.L191L; 7:103092521-103092521

 breastcarcinomaSubstitution - coding silent

c.878T>C; p.I293T; 7:103098399-103098399

 livercarcinomaSubstitution - Missense

c.878T>C; p.I293T; 7:103098399-103098399

 livercarcinomaSubstitution - Missense

c.837A>G; p.R279R; 7:103098358-103098358

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.468G>T; p.E156D; 7:103086704-103086704

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.845C>T; p.T282M; 7:103098366-103098366

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.738T>G; p.S246S; 7:103097309-103097309

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.333T>C; p.P111P; 7:103083770-103083770

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.983A>T; p.H328L; 7:103098504-103098504

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.528G>C; p.K176N; 7:103086764-103086764

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.835C>T; p.R279*; 7:103098356-103098356

 NSmalignant_melanomaSubstitution - Nonsense

c.835C>T; p.R279*; 7:103098356-103098356

 breastcarcinomaSubstitution - Nonsense

c.982C>A; p.H328N; 7:103098503-103098503

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.202G>A; p.G68R; 7:103075839-103075839

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.414T>G; p.G138G; 7:103086650-103086650

 ovaryother; neoplasmSubstitution - coding silent

c.188C>G; p.A63G; 7:103075825-103075825

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.763C>G; p.L255V; 7:103097334-103097334

 central_nervous_system; spinal_cordglioma; ependymomaSubstitution - Missense

c.864G>A; p.K288K; 7:103098385-103098385

 skinmalignant_melanomaSubstitution - coding silent

c.85C>T; p.R29W; 7:103075357-103075357

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.85C>T; p.R29W; 7:103075357-103075357

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.85C>T; p.R29W; 7:103075357-103075357

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.85C>T; p.R29W; 7:103075357-103075357

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.916G>A; p.G306S; 7:103098437-103098437

 skinmalignant_melanomaSubstitution - Missense

c.403C>T; p.R135C; 7:103086639-103086639

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.846G>A; p.T282T; 7:103098367-103098367

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.727T>C; p.L243L; 7:103097298-103097298

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.812A>G; p.H271R; 7:103098333-103098333

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.812A>G; p.H271R; 7:103098333-103098333

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.404G>A; p.R135H; 7:103086640-103086640

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.495G>C; p.L165L; 7:103086731-103086731

 central_nervous_system; brainatypical_teratoid-rhabdoid_tumourSubstitution - coding silent

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