Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

838

Name

CASP5

Synonymous

caspase 5, apoptosis-related cysteine peptidase;CASP5;caspase 5, apoptosis-related cysteine peptidase

Definition

CASP-5|ICE(rel)-III|TY protease|caspase 5, apoptosis-related cysteine protease|caspase-5|protease ICH-3|protease TY

Position

11q22.2-q22.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.32.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.460G>T; p.E154*; 11:105003309-105003309

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.195T>A; p.H65Q; 11:105007273-105007273

 kidneyother; neoplasmSubstitution - Missense

c.518A>G; p.E173G; 11:105002179-105002179

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.518A>G; p.E173G; 11:105002179-105002179

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.518A>G; p.E173G; 11:105002179-105002179

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.195T>A; p.H65Q; 11:105007273-105007273

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.518A>G; p.E173G; 11:105002179-105002179

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.845G>A; p.R282H; 11:105000320-105000320

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.809T>G; p.L270R; 11:105000356-105000356

 skinmalignant_melanomaSubstitution - Missense

c.1065A>T; p.R355S; 11:104997476-104997476

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.10G>A; p.G4S; 11:105008930-105008930

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.305C>T; p.S102F; 11:105007163-105007163

 NSNSSubstitution - Missense

c.95T>C; p.L32P; 11:105008845-105008845

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.85A>G; p.I29V; 11:105008855-105008855

 skinmalignant_melanomaSubstitution - Missense

c.315G>T; p.K105N; 11:105007153-105007153

 breastcarcinomaSubstitution - Missense

c.1043C>A; p.T348K; 11:104998890-104998890

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1043C>A; p.T348K; 11:104998890-104998890

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1043C>A; p.T348K; 11:104998890-104998890

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.474G>T; p.L158L; 11:105003295-105003295

 livercarcinomaSubstitution - coding silent

c.474G>T; p.L158L; 11:105003295-105003295

 livercarcinomaSubstitution - coding silent

c.404C>T; p.A135V; 11:105003365-105003365

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.875A>T; p.K292M; 11:105000290-105000290

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.783G>A; p.A261A; 11:105000382-105000382

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.63C>A; p.N21K; 11:105008877-105008877

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.403G>C; p.A135P; 11:105003366-105003366

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.402G>T; p.E134D; 11:105003367-105003367

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.39C>T; p.F13F; 11:105008901-105008901

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.133A>C; p.K45Q; 11:105008807-105008807

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.461A>T; p.E154V; 11:105003308-105003308

 skinmalignant_melanomaSubstitution - Missense

c.498C>A; p.I166I; 11:105002199-105002199

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.805G>A; p.V269M; 11:105000360-105000360

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.512delA; p.K171fs*33; 11:105002185-105002185

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.917A>T; p.E306V; 11:104999016-104999016

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.67G>T; p.V23L; 11:105008873-105008873

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.386C>T; p.P129L; 11:105003383-105003383

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.386C>T; p.P129L; 11:105003383-105003383

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.869A>T; p.K290I; 11:105000296-105000296

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.607A>G; p.M203V; 11:105002090-105002090

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1028C>A; p.A343D; 11:104998905-104998905

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1180C>T; p.P394S; 11:104995821-104995821

 skinmalignant_melanomaSubstitution - Missense

c.1087T>G; p.F363V; 11:104997454-104997454

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.119C>T; p.S40L; 11:105008821-105008821

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.134-7C>T; p.?; 11:105007341-105007341

 urinary_tract; bladdercarcinomaUnknown

c.341C>T; p.T114I; 11:105007127-105007127

 skinmalignant_melanomaSubstitution - Missense

c.352C>T; p.L118F; 11:105007116-105007116

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1250G>A; p.G417D; 11:104995751-104995751

 skinmalignant_melanomaSubstitution - Missense

c.117G>T; p.K39N; 11:105008823-105008823

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.154_155insT; p.T52fs*3; 11:105007313-105007314

 lungcarcinoma; adenocarcinomaInsertion - Frameshift

c.731C>T; p.T244M; 11:105000434-105000434

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1256G>C; p.*419S; 11:104995745-104995745

 lungcarcinoma; adenocarcinomaNonstop extension

c.743T>C; p.L248P; 11:105000422-105000422

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.878T>C; p.V293A; 11:105000287-105000287

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.600C>T; p.I200I; 11:105002097-105002097

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.261T>G; p.Y87*; 11:105007207-105007207

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1208T>C; p.I403T; 11:104995793-104995793

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.493G>A; p.E165K; 11:105003276-105003276

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.19C>T; p.Q7*; 11:105008921-105008921

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.975G>T; p.E325D; 11:104998958-104998958

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1245T>C; p.F415F; 11:104995756-104995756

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.388C>G; p.L130V; 11:105003381-105003381

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.872C>T; p.P291L; 11:105000293-105000293

 skinmalignant_melanomaSubstitution - Missense

c.221A>T; p.H74L; 11:105007247-105007247

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.221A>T; p.H74L; 11:105007247-105007247

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.600C>A; p.I200I; 11:105002097-105002097

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.251delA; p.K84fs*14; 11:105007217-105007217

 pleurapulmonary_blastomaDeletion - Frameshift

c.648C>T; p.D216D; 11:105002049-105002049

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.451C>A; p.P151T; 11:105003318-105003318

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.108G>A; p.T36T; 11:105008832-105008832

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.975G>A; p.E325E; 11:104998958-104998958

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.805G>T; p.V269L; 11:105000360-105000360

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.293T>C; p.I98T; 11:105007175-105007175

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.31G>A; p.D11N; 11:105008909-105008909

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.649G>A; p.E217K; 11:105002048-105002048

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1153C>T; p.R385W; 11:104997388-104997388

 skinmalignant_melanomaSubstitution - Missense

c.1153C>T; p.R385W; 11:104997388-104997388

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1153C>T; p.R385W; 11:104997388-104997388

 skinmalignant_melanomaSubstitution - Missense

c.1153C>T; p.R385W; 11:104997388-104997388

 skinmalignant_melanomaSubstitution - Missense

c.252G>T; p.K84N; 11:105007216-105007216

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.775G>A; p.G259R; 11:105000390-105000390

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.495G>T; p.E165D; 11:105003274-105003274

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.477_478insA; p.N162fs*3; 11:105003291-105003292

 lungcarcinoma; non_small_cell_carcinomaInsertion - Frameshift

c.684G>A; p.V228V; 11:105000481-105000481

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.15C>A; p.I5I; 11:105008925-105008925

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.446T>A; p.L149H; 11:105003323-105003323

 livercarcinomaSubstitution - Missense

c.519G>C; p.E173D; 11:105002178-105002178

 livercarcinomaSubstitution - Missense

c.1251C>A; p.G417G; 11:104995750-104995750

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.519G>C; p.E173D; 11:105002178-105002178

 livercarcinomaSubstitution - Missense

c.519G>C; p.E173D; 11:105002178-105002178

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.311G>A; p.R104Q; 11:105007157-105007157

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.291G>A; p.L97L; 11:105007177-105007177

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.635_636AC>TT; p.Y212F; 11:105002061-105002062

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.543C>T; p.I181I; 11:105002154-105002154

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1089C>T; p.F363F; 11:104997452-104997452

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1048C>T; p.H350Y; 11:104998885-104998885

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.522C>G; p.D174E; 11:105002175-105002175

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.153_154delAA; p.K51fs*3; 11:105007314-105007315

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.153_154delAA; p.K51fs*3; 11:105007314-105007315

 oesophagus; lower_thirdcarcinoma; adenocarcinomaDeletion - Frameshift

c.40G>A; p.V14M; 11:105008900-105008900

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.286G>C; p.A96P; 11:105007182-105007182

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.223G>A; p.D75N; 11:105007245-105007245

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.223G>A; p.D75N; 11:105007245-105007245

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.812T>G; p.L271R; 11:105000353-105000353

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.135A>C; p.K45N; 11:105007333-105007333

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.822C>A; p.T274T; 11:105000343-105000343

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.452C>A; p.P151H; 11:105003317-105003317

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1158G>T; p.K386N; 11:104997383-104997383

 pancreascarcinomaSubstitution - Missense

c.399C>T; p.I133I; 11:105003370-105003370

 skinmalignant_melanomaSubstitution - coding silent

c.364C>T; p.Q122*; 11:105007104-105007104

 skinmalignant_melanomaSubstitution - Nonsense

c.481A>C; p.K161Q; 11:105003288-105003288

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.485_486insA; p.N162fs*3; 11:105003283-105003284

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.562G>C; p.D188H; 11:105002135-105002135

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1169C>A; p.S390*; 11:104995832-104995832

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1169C>A; p.S390*; 11:104995832-104995832

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.892G>A; p.A298T; 11:105000273-105000273

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.909A>C; p.K303N; 11:104999024-104999024

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.385+7T>C; p.?; 11:105007076-105007076

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.385+7T>C; p.?; 11:105007076-105007076

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.385+7T>C; p.?; 11:105007076-105007076

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.346A>G; p.T116A; 11:105007122-105007122

 skinmalignant_melanomaSubstitution - Missense

c.485delA; p.N162fs*8; 11:105003284-105003284

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.485delA; p.N162fs*8; 11:105003284-105003284

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.485delA; p.N162fs*8; 11:105003284-105003284

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.485delA; p.N162fs*8; 11:105003284-105003284

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.485delA; p.N162fs*8; 11:105003284-105003284

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.534G>A; p.L178L; 11:105002163-105002163

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.305C>G; p.S102C; 11:105007163-105007163

 breastcarcinomaSubstitution - Missense

c.305C>G; p.S102C; 11:105007163-105007163

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.749C>T; p.S250F; 11:105000416-105000416

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1086C>T; p.I362I; 11:104997455-104997455

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.959C>T; p.S320F; 11:104998974-104998974

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.385C>T; p.P129S; 11:105007083-105007083

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1159-8T>C; p.?; 11:104995850-104995850

 livercarcinomaUnknown

c.1159-8T>C; p.?; 11:104995850-104995850

 livercarcinomaUnknown

c.1159-8T>C; p.?; 11:104995850-104995850

 livercarcinomaUnknown

c.664G>A; p.A222T; 11:105002033-105002033

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.872C>G; p.P291R; 11:105000293-105000293

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.519G>T; p.E173D; 11:105002178-105002178

 oesophaguscarcinomaSubstitution - Missense

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; rectumcarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.468G>C; p.L156L; 11:105003301-105003301

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.137A>G; p.D46G; 11:105007331-105007331

 livercarcinomaSubstitution - Missense

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 livercarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; rectumcarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 ovarycarcinoma; serous_carcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.154delA; p.T52fs*26; 11:105007314-105007314

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.107C>T; p.T36M; 11:105008833-105008833

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.107C>T; p.T36M; 11:105008833-105008833

 thyroidcarcinomaSubstitution - Missense

c.176T>C; p.L59P; 11:105007292-105007292

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.325G>A; p.A109T; 11:105007143-105007143

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.581A>T; p.N194I; 11:105002116-105002116

 breastcarcinomaSubstitution - Missense

c.241G>A; p.E81K; 11:105007227-105007227

 skinmalignant_melanomaSubstitution - Missense

c.241G>A; p.E81K; 11:105007227-105007227

 skinmalignant_melanomaSubstitution - Missense

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