| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 8404 |
Name | SPARCL1 |
Synonymous | SPARC-like 1 (hevin);SPARCL1;SPARC-like 1 (hevin) |
Definition | SPARC-like protein 1|high endothelial venule protein|proliferation-inducing protein 33 |
Position | 4q22.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.11. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.20delT; p.F7fs*29; 4:87499555-87499555 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.20delT; p.F7fs*29; 4:87499555-87499555 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.20delT; p.F7fs*29; 4:87499555-87499555 |
lung | carcinoma; small_cell_carcinoma | Deletion - Frameshift |
c.1550A>G; p.D517G; 4:87482542-87482542 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.888A>G; p.Q296Q; 4:87493912-87493912 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.743A>G; p.D248G; 4:87494057-87494057 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.468T>C; p.S156S; 4:87494332-87494332 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.904C>A; p.L302I; 4:87493896-87493896 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.995C>G; p.P332R; 4:87493805-87493805 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1157A>G; p.Q386R; 4:87493643-87493643 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.882G>T; p.Q294H; 4:87493918-87493918 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.644A>C; p.N215T; 4:87494156-87494156 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1762T>A; p.Y588N; 4:87480427-87480427 |
kidney | other; neoplasm | Substitution - Missense |
c.1688A>T; p.D563V; 4:87480501-87480501 |
liver | carcinoma | Substitution - Missense |
c.1688A>T; p.D563V; 4:87480501-87480501 |
liver | carcinoma | Substitution - Missense |
c.21C>T; p.F7F; 4:87499554-87499554 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.719C>G; p.S240C; 4:87494081-87494081 |
bone; extraskeletal | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.918C>A; p.S306R; 4:87493882-87493882 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1434C>T; p.T478T; 4:87490370-87490370 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1550A>T; p.D517V; 4:87482542-87482542 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.419T>C; p.F140S; 4:87494381-87494381 |
breast | carcinoma | Substitution - Missense |
c.676A>G; p.R226G; 4:87494124-87494124 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1305C>A; p.S435R; 4:87490865-87490865 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.561T>A; p.D187E; 4:87494239-87494239 |
thyroid | carcinoma | Substitution - Missense |
c.1323C>T; p.G441G; 4:87490847-87490847 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1546A>G; p.T516A; 4:87482546-87482546 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1180G>A; p.E394K; 4:87493620-87493620 |
skin | malignant_melanoma | Substitution - Missense |
c.1078G>A; p.D360N; 4:87493722-87493722 |
breast | carcinoma | Substitution - Missense |
c.1418G>C; p.G473A; 4:87490386-87490386 |
breast | carcinoma | Substitution - Missense |
c.112G>A; p.D38N; 4:87495070-87495070 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.176C>T; p.S59F; 4:87495006-87495006 |
breast | carcinoma | Substitution - Missense |
c.880C>T; p.Q294*; 4:87493920-87493920 |
breast | carcinoma | Substitution - Nonsense |
c.816C>A; p.S272S; 4:87493984-87493984 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1984C>G; p.L662V; 4:87473786-87473786 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.634G>A; p.G212S; 4:87494166-87494166 |
liver | carcinoma | Substitution - Missense |
c.1881_1892del12; p.T628_F631delTRFF; 4:87479504-87479515 |
skin | malignant_melanoma | Deletion - In frame |
c.1061G>A; p.R354K; 4:87493739-87493739 |
skin | malignant_melanoma | Substitution - Missense |
c.1499A>G; p.Q500R; 4:87490305-87490305 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1349G>A; p.G450E; 4:87490821-87490821 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1890C>A; p.F630L; 4:87479506-87479506 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1337C>T; p.A446V; 4:87490833-87490833 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.823G>T; p.E275*; 4:87493977-87493977 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.823G>T; p.E275*; 4:87493977-87493977 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Nonsense |
c.304G>A; p.D102N; 4:87494496-87494496 |
skin | malignant_melanoma | Substitution - Missense |
c.393G>T; p.E131D; 4:87494407-87494407 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.74C>G; p.S25C; 4:87495108-87495108 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1482G>A; p.G494G; 4:87490322-87490322 |
skin | malignant_melanoma | Substitution - coding silent |
c.1697G>A; p.R566K; 4:87480492-87480492 |
skin; trunk | malignant_melanoma; nodular | Substitution - Missense |
c.963C>T; p.L321L; 4:87493837-87493837 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.633T>C; p.V211V; 4:87494167-87494167 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.934G>A; p.E312K; 4:87493866-87493866 |
skin | malignant_melanoma | Substitution - Missense |
c.1387C>A; p.P463T; 4:87490783-87490783 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1035C>T; p.G345G; 4:87493765-87493765 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1618G>T; p.E540*; 4:87482474-87482474 |
ovary | carcinoma; clear_cell_carcinoma | Substitution - Nonsense |
c.1852G>A; p.A618T; 4:87479544-87479544 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1255A>G; p.T419A; 4:87491654-87491654 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.1915G>A; p.D639N; 4:87479481-87479481 |
skin | malignant_melanoma | Substitution - Missense |
c.907G>A; p.E303K; 4:87493893-87493893 |
skin | malignant_melanoma | Substitution - Missense |
c.1529A>G; p.K510R; 4:87490275-87490275 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1049C>A; p.T350N; 4:87493751-87493751 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.146C>A; p.A49D; 4:87495036-87495036 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.146C>A; p.A49D; 4:87495036-87495036 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.146C>A; p.A49D; 4:87495036-87495036 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.146C>A; p.A49D; 4:87495036-87495036 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.146C>A; p.A49D; 4:87495036-87495036 |
kidney | other; neoplasm | Substitution - Missense |
c.1116G>A; p.E372E; 4:87493684-87493684 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.1116G>A; p.E372E; 4:87493684-87493684 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - coding silent |
c.845C>T; p.S282L; 4:87493955-87493955 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.845C>T; p.S282L; 4:87493955-87493955 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.845C>T; p.S282L; 4:87493955-87493955 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.667G>C; p.E223Q; 4:87494133-87494133 |
breast | carcinoma | Substitution - Missense |
c.1881A>G; p.I627M; 4:87479515-87479515 |
skin | malignant_melanoma | Substitution - Missense |
c.749C>T; p.P250L; 4:87494051-87494051 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.415G>A; p.D139N; 4:87494385-87494385 |
skin | malignant_melanoma | Substitution - Missense |
c.879G>C; p.W293C; 4:87493921-87493921 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.884G>T; p.S295I; 4:87493916-87493916 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1975G>A; p.D659N; 4:87473795-87473795 |
skin | malignant_melanoma | Substitution - Missense |
c.529A>G; p.R177G; 4:87494271-87494271 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.529A>G; p.R177G; 4:87494271-87494271 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1075G>C; p.D359H; 4:87493725-87493725 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.116A>G; p.N39S; 4:87495066-87495066 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1075G>C; p.D359H; 4:87493725-87493725 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.828G>A; p.M276I; 4:87493972-87493972 |
skin | malignant_melanoma | Substitution - Missense |
c.1024G>A; p.D342N; 4:87493776-87493776 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1024G>A; p.D342N; 4:87493776-87493776 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.431G>A; p.G144D; 4:87494369-87494369 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.627T>G; p.G209G; 4:87494173-87494173 |
breast | carcinoma | Substitution - coding silent |
c.382G>A; p.E128K; 4:87494418-87494418 |
skin; mucosal | malignant_melanoma | Substitution - Missense |
c.1674G>A; p.K558K; 4:87480515-87480515 |
skin | malignant_melanoma | Substitution - coding silent |
c.1679T>G; p.I560S; 4:87480510-87480510 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.205G>C; p.E69Q; 4:87494595-87494595 |
liver | carcinoma | Substitution - Missense |
c.205G>C; p.E69Q; 4:87494595-87494595 |
liver | carcinoma | Substitution - Missense |
c.1994G>C; p.*665S; 4:87473776-87473776 |
urinary_tract; bladder | carcinoma | Nonstop extension |
c.1160G>C; p.R387T; 4:87493640-87493640 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.303G>T; p.E101D; 4:87494497-87494497 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.740C>G; p.S247C; 4:87494060-87494060 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - Missense |
c.129C>A; p.P43P; 4:87495053-87495053 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.399_400insA; p.L134fs*6; 4:87494400-87494401 |
large_intestine | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.460C>G; p.Q154E; 4:87494340-87494340 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.593C>T; p.S198F; 4:87494207-87494207 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1519G>A; p.G507R; 4:87490285-87490285 |
thyroid | carcinoma; anaplastic_carcinoma | Substitution - Missense |
c.1972A>G; p.I658V; 4:87473798-87473798 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.54G>A; p.P18P; 4:87499521-87499521 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.865C>A; p.Q289K; 4:87493935-87493935 |
ovary | other; neoplasm | Substitution - Missense |
c.1434C>A; p.T478T; 4:87490370-87490370 |
breast | carcinoma | Substitution - coding silent |
c.1625A>G; p.N542S; 4:87482467-87482467 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.618A>G; p.K206K; 4:87494182-87494182 |
lung | carcinoma; non_small_cell_carcinoma | Substitution - coding silent |
c.1060A>G; p.R354G; 4:87493740-87493740 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1439C>T; p.A480V; 4:87490365-87490365 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1858C>A; p.L620M; 4:87479538-87479538 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.844T>A; p.S282T; 4:87493956-87493956 |
skin | malignant_melanoma | Substitution - Missense |
c.861C>T; p.H287H; 4:87493939-87493939 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.784G>A; p.D262N; 4:87494016-87494016 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1459G>A; p.A487T; 4:87490345-87490345 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1955G>A; p.G652E; 4:87479441-87479441 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.186C>T; p.D62D; 4:87494996-87494996 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.316C>G; p.H106D; 4:87494484-87494484 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.316C>G; p.H106D; 4:87494484-87494484 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.316C>G; p.H106D; 4:87494484-87494484 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.316C>G; p.H106D; 4:87494484-87494484 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.78T>G; p.D26E; 4:87495104-87495104 |
oesophagus | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.534C>A; p.S178R; 4:87494266-87494266 |
skin; ear | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1510G>A; p.D504N; 4:87490294-87490294 |
skin | malignant_melanoma | Substitution - Missense |
c.532A>T; p.S178C; 4:87494268-87494268 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1635C>T; p.H545H; 4:87482457-87482457 |
thyroid | other; neoplasm | Substitution - coding silent |
c.1635C>T; p.H545H; 4:87482457-87482457 |
oesophagus; middle_third | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1746G>C; p.K582N; 4:87480443-87480443 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.108A>C; p.A36A; 4:87495074-87495074 |
thyroid | other; neoplasm | Substitution - coding silent |
c.1746delG; p.N584fs*25; 4:87480443-87480443 |
breast | carcinoma; basal_(triple-negative)_carcinoma | Deletion - Frameshift |
c.1040A>G; p.D347G; 4:87493760-87493760 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1233G>T; p.E411D; 4:87491676-87491676 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |