Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

84289

Name

ING5

Synonymous

inhibitor of growth family, member 5;ING5;inhibitor of growth family, member 5

Definition

inhibitor of growth protein 5

Position

2q37.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.10.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.322G>A; p.E108K; 2:241711422-241711422

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.333G>A; p.L111L; 2:241711433-241711433

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.663G>A; p.T221T; 2:241723254-241723254

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.152C>T; p.S51F; 2:241709258-241709258

 skinmalignant_melanomaSubstitution - Missense

c.305C>T; p.A102V; 2:241711405-241711405

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.75C>T; p.F25F; 2:241704690-241704690

 skinmalignant_melanomaSubstitution - coding silent

c.482+1G>T; p.?; 2:241712072-241712072

 stomachcarcinoma; intestinal_adenocarcinomaUnknown

c.184G>A; p.V62M; 2:241709290-241709290

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.80T>A; p.L27Q; 2:241704695-241704695

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.142G>C; p.E48Q; 2:241709248-241709248

 breastcarcinomaSubstitution - Missense

c.301G>A; p.D101N; 2:241711401-241711401

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.137C>T; p.A46V; 2:241709243-241709243

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.402G>A; p.Q134Q; 2:241711991-241711991

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.369C>T; p.S123S; 2:241711469-241711469

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.637C>A; p.H213N; 2:241723228-241723228

 livercarcinomaSubstitution - Missense

c.637C>A; p.H213N; 2:241723228-241723228

 livercarcinomaSubstitution - Missense

c.637C>A; p.H213N; 2:241723228-241723228

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.425G>A; p.G142D; 2:241712014-241712014

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.252G>A; p.Q84Q; 2:241709358-241709358

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.252G>A; p.Q84Q; 2:241709358-241709358

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.86G>A; p.R29Q; 2:241704701-241704701

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.165G>A; p.T55T; 2:241709271-241709271

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.292C>T; p.R98*; 2:241711392-241711392

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.53C>T; p.P18L; 2:241704668-241704668

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.427C>T; p.R143*; 2:241712016-241712016

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.693G>A; p.R231R; 2:241725001-241725001

 skinmalignant_melanomaSubstitution - coding silent

c.553G>A; p.E185K; 2:241723009-241723009

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.702G>A; p.Q234Q; 2:241725010-241725010

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.692G>T; p.R231L; 2:241725000-241725000

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.40A>G; p.I14V; 2:241704655-241704655

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.40A>G; p.I14V; 2:241704655-241704655

 large_intestine; coloncarcinomaSubstitution - Missense

c.315G>A; p.A105A; 2:241711415-241711415

 pancreascarcinomaSubstitution - coding silent

c.104C>T; p.T35M; 2:241704719-241704719

 kidneyother; neoplasmSubstitution - Missense

c.388+6T>A; p.?; 2:241711494-241711494

 skin; trunkmalignant_melanoma; nodularUnknown

c.607G>A; p.D203N; 2:241723063-241723063

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.679T>C; p.W227R; 2:241723270-241723270

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.42C>T; p.I14I; 2:241704657-241704657

 skinmalignant_melanomaSubstitution - coding silent

c.42C>T; p.I14I; 2:241704657-241704657

 skinmalignant_melanomaSubstitution - coding silent

c.681G>T; p.W227C; 2:241724989-241724989

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.597G>A; p.M199I; 2:241723053-241723053

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.155C>T; p.T52M; 2:241709261-241709261

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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