| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 84897 |
Name | TBRG1 |
Synonymous | transforming growth factor beta regulator 1;TBRG1;transforming growth factor beta regulator 1 |
Definition | nuclear interactor of ARF and MDM2 |
Position | 11q24.2 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.00. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.763C>T; p.P255S; 11:124632218-124632218 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.424delT; p.F143fs*11; 11:124630785-124630785 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.638-6C>A; p.?; 11:124632087-124632087 |
liver | carcinoma | Unknown |
c.413C>T; p.A138V; 11:124630774-124630774 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.641C>T; p.S214F; 11:124632096-124632096 |
skin | malignant_melanoma | Substitution - Missense |
c.78T>A; p.H26Q; 11:124625843-124625843 |
pancreas | carcinoma | Substitution - Missense |
c.78T>A; p.H26Q; 11:124625843-124625843 |
pancreas | carcinoma | Substitution - Missense |
c.304G>C; p.D102H; 11:124630406-124630406 |
prostate | carcinoma | Substitution - Missense |
c.220A>C; p.M74L; 11:124626985-124626985 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.771G>C; p.Q257H; 11:124632226-124632226 |
pancreas | carcinoma | Substitution - Missense |
c.532G>A; p.D178N; 11:124631312-124631312 |
breast | carcinoma | Substitution - Missense |
c.638-6C>T; p.?; 11:124632087-124632087 |
lung | carcinoma; squamous_cell_carcinoma | Unknown |
c.178A>T; p.I60F; 11:124626943-124626943 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.669A>T; p.A223A; 11:124632124-124632124 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.466A>C; p.S156R; 11:124630827-124630827 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.333T>C; p.S111S; 11:124630435-124630435 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.494+10A>G; p.?; 11:124630865-124630865 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Unknown |
c.201T>A; p.S67R; 11:124626966-124626966 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.655G>A; p.E219K; 11:124632110-124632110 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.451C>T; p.H151Y; 11:124630812-124630812 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.132C>A; p.N44K; 11:124625897-124625897 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |