Entrez Gene

Basic Information
Gene ID	8633
Name	UNC5C
Synonymous	unc-5 homolog C (C. elegans);UNC5C;unc-5 homolog C (C. elegans)
Definition	netrin receptor UNC5C\|protein unc-5 homolog 3\|protein unc-5 homolog C\|unc-5 homolog 3\|unc5 (C.elegans homolog) c
Position	4q21-q23
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.704C>A; p.A235E; 4:95250558-95250558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.240C>G; p.N80K; 4:95335516-95335516	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1025C>T; p.A342V; 4:95242512-95242512	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1414G>A; p.D472N; 4:95219200-95219200	skin	malignant_melanoma	Substitution - Missense
c.1924G>A; p.E642K; 4:95202943-95202943	skin	malignant_melanoma	Substitution - Missense
c.1667C>T; p.A556V; 4:95216190-95216190	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.115G>A; p.A39T; 4:95548743-95548743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1383C>A; p.D461E; 4:95219231-95219231	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1063C>A; p.L355I; 4:95242474-95242474	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.538T>A; p.L180M; 4:95278315-95278315	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2313T>A; p.S771R; 4:95183035-95183035	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.578G>C; p.G193A; 4:95278275-95278275	breast	carcinoma	Substitution - Missense
c.1695C>T; p.Y565Y; 4:95216162-95216162	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.764T>A; p.V255D; 4:95250498-95250498	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1949T>A; p.I650N; 4:95202918-95202918	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2003C>G; p.A668G; 4:95202864-95202864	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1921G>T; p.E641*; 4:95202946-95202946	liver	carcinoma	Substitution - Nonsense
c.2443G>A; p.V815M; 4:95182905-95182905	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1827G>T; p.M609I; 4:95206703-95206703	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2099G>A; p.R700Q; 4:95202768-95202768	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2099G>A; p.R700Q; 4:95202768-95202768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2099G>A; p.R700Q; 4:95202768-95202768	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2099G>A; p.R700Q; 4:95202768-95202768	skin; extremity	malignant_melanoma	Substitution - Missense
c.2099G>A; p.R700Q; 4:95202768-95202768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1748A>C; p.D583A; 4:95206782-95206782	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.380C>T; p.S127L; 4:95301716-95301716	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1569A>G; p.A523A; 4:95219045-95219045	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.380C>T; p.S127L; 4:95301716-95301716	skin	malignant_melanoma	Substitution - Missense
c.1066G>A; p.V356I; 4:95242471-95242471	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1066G>A; p.V356I; 4:95242471-95242471	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1038G>T; p.K346N; 4:95242499-95242499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2544C>A; p.I848I; 4:95170240-95170240	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.357C>A; p.V119V; 4:95301739-95301739	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1065C>T; p.L355L; 4:95242472-95242472	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.2134_2136+1delAAGG; p.?; 4:95202730-95202733	liver	carcinoma	Unknown
c.2014C>A; p.H672N; 4:95202853-95202853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2226C>A; p.R742R; 4:95185107-95185107	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1685G>A; p.G562E; 4:95216172-95216172	skin	malignant_melanoma	Substitution - Missense
c.1015G>A; p.E339K; 4:95242522-95242522	skin	malignant_melanoma	Substitution - Missense
c.102C>T; p.S34S; 4:95548756-95548756	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2511G>A; p.T837T; 4:95170273-95170273	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1165G>A; p.V389I; 4:95220120-95220120	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2545C>T; p.R849W; 4:95170239-95170239	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2384G>T; p.C795F; 4:95182964-95182964	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - Missense
c.2160G>A; p.Q720Q; 4:95185173-95185173	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1060G>A; p.G354S; 4:95242477-95242477	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1984G>A; p.E662K; 4:95202883-95202883	bone; femur	chondrosarcoma	Substitution - Missense
c.2609C>T; p.A870V; 4:95170175-95170175	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1792G>A; p.G598R; 4:95206738-95206738	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1069T>C; p.L357L; 4:95242468-95242468	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.160C>T; p.P54S; 4:95335596-95335596	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2007G>T; p.L669L; 4:95202860-95202860	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1815C>T; p.V605V; 4:95206715-95206715	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2766G>T; p.V922V; 4:95169264-95169264	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1815C>T; p.V605V; 4:95206715-95206715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1647A>T; p.G549G; 4:95216210-95216210	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.296G>T; p.W99L; 4:95335460-95335460	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1288G>A; p.A430T; 4:95219997-95219997	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1090G>T; p.D364Y; 4:95242447-95242447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1524G>A; p.S508S; 4:95219090-95219090	skin	malignant_melanoma	Substitution - coding silent
c.2565C>A; p.S855R; 4:95170219-95170219	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1524G>A; p.S508S; 4:95219090-95219090	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.297G>A; p.W99*; 4:95335459-95335459	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1719G>A; p.R573R; 4:95216138-95216138	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1733G>T; p.R578M; 4:95216124-95216124	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.547G>A; p.E183K; 4:95278306-95278306	skin	malignant_melanoma	Substitution - Missense
c.2012G>A; p.G671E; 4:95202855-95202855	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.547G>A; p.E183K; 4:95278306-95278306	skin; mucosal	malignant_melanoma	Substitution - Missense
c.2339C>T; p.T780I; 4:95183009-95183009	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2212_2213insA; p.T738fs*23; 4:95185120-95185121	ovary	carcinoma; serous_carcinoma	Insertion - Frameshift
c.912G>T; p.V304V; 4:95245008-95245008	upper_aerodigestive_tract; sinonasal_and_nasal_cavity	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1345T>C; p.Y449H; 4:95219269-95219269	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2611C>A; p.H871N; 4:95170173-95170173	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2165G>A; p.G722E; 4:95185168-95185168	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1059C>T; p.D353D; 4:95242478-95242478	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.927T>C; p.C309C; 4:95244993-95244993	skin	malignant_melanoma	Substitution - coding silent
c.1070T>G; p.L357W; 4:95242467-95242467	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2671G>A; p.V891I; 4:95169359-95169359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2013A>G; p.G671G; 4:95202854-95202854	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.974G>A; p.W325*; 4:95242563-95242563	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.130G>A; p.D44N; 4:95335626-95335626	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.630C>T; p.P210P; 4:95250632-95250632	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.637G>T; p.D213Y; 4:95250625-95250625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2431C>T; p.L811F; 4:95182917-95182917	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.358C>T; p.R120W; 4:95301738-95301738	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>A; p.W147*; 4:95301656-95301656	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1649T>C; p.V550A; 4:95216208-95216208	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2082G>A; p.S694S; 4:95202785-95202785	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1036_1037insC; p.K346fs*19; 4:95242500-95242501	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.884G>A; p.G295E; 4:95245036-95245036	liver	carcinoma	Substitution - Missense
c.884G>A; p.G295E; 4:95245036-95245036	liver	carcinoma	Substitution - Missense
c.396A>G; p.E132E; 4:95301700-95301700	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1071G>T; p.L357F; 4:95242466-95242466	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.563G>A; p.C188Y; 4:95278290-95278290	skin	malignant_melanoma	Substitution - Missense
c.2627A>G; p.D876G; 4:95170157-95170157	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1613C>T; p.S538L; 4:95219001-95219001	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1670G>A; p.G557E; 4:95216187-95216187	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.332T>C; p.V111A; 4:95335424-95335424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2679G>A; p.L893L; 4:95169351-95169351	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1665C>G; p.P555P; 4:95216192-95216192	skin	malignant_melanoma	Substitution - coding silent
c.2475G>A; p.P825P; 4:95170309-95170309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.37G>A; p.G13R; 4:95548821-95548821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1556A>C; p.N519T; 4:95219058-95219058	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1556A>C; p.N519T; 4:95219058-95219058	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1556A>C; p.N519T; 4:95219058-95219058	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.901G>T; p.G301W; 4:95245019-95245019	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1033C>T; p.P345S; 4:95242504-95242504	skin	malignant_melanoma	Substitution - Missense
c.1918G>T; p.G640W; 4:95202949-95202949	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.382C>G; p.R128G; 4:95301714-95301714	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1733+2T>C; p.?; 4:95216122-95216122	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.168T>C; p.D56D; 4:95335588-95335588	thyroid	other; neoplasm	Substitution - coding silent
c.1778G>T; p.S593I; 4:95206752-95206752	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>A; p.E170K; 4:95278345-95278345	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.361G>A; p.E121K; 4:95301735-95301735	skin	malignant_melanoma	Substitution - Missense
c.1306C>A; p.L436M; 4:95219308-95219308	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.812T>C; p.V271A; 4:95245108-95245108	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2098C>T; p.R700*; 4:95202769-95202769	oesophagus	carcinoma	Substitution - Nonsense
c.1060G>C; p.G354R; 4:95242477-95242477	skin	malignant_melanoma	Substitution - Missense
c.337G>A; p.E113K; 4:95335419-95335419	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1838C>A; p.A613E; 4:95206692-95206692	liver	carcinoma	Substitution - Missense
c.800C>T; p.T267M; 4:95245120-95245120	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1593C>T; p.T531T; 4:95219021-95219021	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1128T>C; p.D376D; 4:95220157-95220157	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1320A>T; p.P440P; 4:95219294-95219294	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1517C>T; p.T506I; 4:95219097-95219097	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2029G>T; p.A677S; 4:95202838-95202838	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1548C>T; p.S516S; 4:95219066-95219066	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.345C>T; p.S115S; 4:95335411-95335411	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1340C>T; p.A447V; 4:95219274-95219274	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1091A>T; p.D364V; 4:95242446-95242446	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2138A>C; p.E713A; 4:95185195-95185195	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1388T>C; p.I463T; 4:95219226-95219226	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1428C>T; p.N476N; 4:95219186-95219186	liver	carcinoma	Substitution - coding silent
c.1428C>T; p.N476N; 4:95219186-95219186	liver	carcinoma	Substitution - coding silent
c.406G>C; p.G136R; 4:95301690-95301690	breast	carcinoma	Substitution - Missense
c.1400A>G; p.N467S; 4:95219214-95219214	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.530A>G; p.E177G; 4:95278323-95278323	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1477G>A; p.D493N; 4:95219137-95219137	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.592G>A; p.E198K; 4:95278261-95278261	urinary_tract; bladder	carcinoma	Substitution - Missense
c.592G>A; p.E198K; 4:95278261-95278261	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.592G>A; p.E198K; 4:95278261-95278261	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.279C>T; p.F93F; 4:95335477-95335477	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.85G>A; p.A29T; 4:95548773-95548773	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2030C>T; p.A677V; 4:95202837-95202837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1573C>A; p.Q525K; 4:95219041-95219041	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.520C>T; p.L174L; 4:95278333-95278333	liver	carcinoma	Substitution - coding silent
c.520C>T; p.L174L; 4:95278333-95278333	liver	carcinoma	Substitution - coding silent
c.2324G>A; p.R775K; 4:95183024-95183024	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.572C>A; p.P191H; 4:95278281-95278281	pancreas	carcinoma	Substitution - Missense
c.2399G>A; p.R800Q; 4:95182949-95182949	liver	carcinoma	Substitution - Missense
c.2364G>A; p.L788L; 4:95182984-95182984	skin	malignant_melanoma	Substitution - coding silent
c.1768C>A; p.P590T; 4:95206762-95206762	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2650A>T; p.T884S; 4:95169380-95169380	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.518C>T; p.P173L; 4:95278335-95278335	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1952A>T; p.Q651L; 4:95202915-95202915	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1326C>A; p.L442L; 4:95219288-95219288	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.785G>T; p.G262V; 4:95245135-95245135	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1812A>C; p.P604P; 4:95206718-95206718	thyroid	other; neoplasm	Substitution - coding silent
c.2168G>A; p.G723E; 4:95185165-95185165	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1666G>T; p.A556S; 4:95216191-95216191	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1594G>A; p.A532T; 4:95219020-95219020	pancreas	carcinoma	Substitution - Missense
c.1594G>A; p.A532T; 4:95219020-95219020	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1816G>A; p.V606I; 4:95206714-95206714	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1816G>A; p.V606I; 4:95206714-95206714	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.552C>T; p.V184V; 4:95278301-95278301	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1664C>T; p.P555L; 4:95216193-95216193	skin	malignant_melanoma	Substitution - Missense
c.481C>T; p.R161C; 4:95301615-95301615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2239G>A; p.D747N; 4:95185094-95185094	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1318C>T; p.P440S; 4:95219296-95219296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1443G>T; p.V481V; 4:95219171-95219171	liver	carcinoma	Substitution - coding silent
c.2239G>A; p.D747N; 4:95185094-95185094	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1518C>A; p.T506T; 4:95219096-95219096	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1329G>T; p.T443T; 4:95219285-95219285	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1518C>A; p.T506T; 4:95219096-95219096	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.780C>T; p.N260N; 4:95245140-95245140	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.1148T>A; p.I383N; 4:95220137-95220137	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1179C>T; p.I393I; 4:95220106-95220106	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.1179C>T; p.I393I; 4:95220106-95220106	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2089T>C; p.Y697H; 4:95202778-95202778	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2664A>G; p.P888P; 4:95169366-95169366	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2089T>C; p.Y697H; 4:95202778-95202778	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.291T>C; p.S97S; 4:95335465-95335465	thyroid	other; neoplasm	Substitution - coding silent
c.2089T>C; p.Y697H; 4:95202778-95202778	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.291T>C; p.S97S; 4:95335465-95335465	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1219C>T; p.R407C; 4:95220066-95220066	breast	carcinoma	Substitution - Missense
c.1056C>T; p.C352C; 4:95242481-95242481	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.624T>C; p.I208I; 4:95250638-95250638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056C>T; p.C352C; 4:95242481-95242481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056C>T; p.C352C; 4:95242481-95242481	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056C>T; p.C352C; 4:95242481-95242481	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1807C>A; p.R603S; 4:95206723-95206723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2779G>A; p.A927T; 4:95169251-95169251	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2146C>T; p.H716Y; 4:95185187-95185187	liver	carcinoma	Substitution - Missense
c.669C>T; p.N223N; 4:95250593-95250593	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.202C>G; p.P68A; 4:95335554-95335554	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.192C>T; p.F64F; 4:95335564-95335564	skin	malignant_melanoma	Substitution - coding silent
c.523G>A; p.G175R; 4:95278330-95278330	skin	malignant_melanoma	Substitution - Missense
c.908G>C; p.S303T; 4:95245012-95245012	breast	carcinoma	Substitution - Missense
c.2416G>A; p.G806R; 4:95182932-95182932	skin	malignant_melanoma	Substitution - Missense
c.532G>A; p.V178M; 4:95278321-95278321	liver	carcinoma	Substitution - Missense
c.1837G>A; p.A613T; 4:95206693-95206693	pancreas	carcinoma	Substitution - Missense
c.2508C>A; p.V836V; 4:95170276-95170276	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1837G>A; p.A613T; 4:95206693-95206693	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.532G>A; p.V178M; 4:95278321-95278321	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.320T>C; p.V107A; 4:95335436-95335436	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.727A>C; p.N243H; 4:95250535-95250535	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.942A>T; p.P314P; 4:95244978-95244978	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2643C>G; p.Y881*; 4:95169387-95169387	NS	NS	Substitution - Nonsense
c.313C>T; p.H105Y; 4:95335443-95335443	skin	malignant_melanoma	Substitution - Missense
c.1976T>A; p.I659N; 4:95202891-95202891	liver	carcinoma	Substitution - Missense
c.1976T>A; p.I659N; 4:95202891-95202891	liver	carcinoma	Substitution - Missense
c.986G>A; p.G329E; 4:95242551-95242551	skin	malignant_melanoma	Substitution - Missense
c.1171C>G; p.L391V; 4:95220114-95220114	pancreas	carcinoid-endocrine_tumour; islet_cell	Substitution - Missense
c.2721C>T; p.S907S; 4:95169309-95169309	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.986G>A; p.G329E; 4:95242551-95242551	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2515C>T; p.P839S; 4:95170269-95170269	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2125G>A; p.D709N; 4:95202742-95202742	skin	malignant_melanoma	Substitution - Missense
c.590C>A; p.A197D; 4:95278263-95278263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2111T>C; p.L704P; 4:95202756-95202756	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2515C>T; p.P839S; 4:95170269-95170269	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.464G>A; p.S155N; 4:95301632-95301632	urinary_tract; bladder	carcinoma	Substitution - Missense
c.321A>C; p.V107V; 4:95335435-95335435	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2149C>A; p.L717I; 4:95185184-95185184	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1405C>T; p.P469S; 4:95219209-95219209	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.832C>T; p.R278*; 4:95245088-95245088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.832C>T; p.R278*; 4:95245088-95245088	prostate	carcinoma	Substitution - Nonsense
c.832C>T; p.R278*; 4:95245088-95245088	pancreas	carcinoma	Substitution - Nonsense
c.832C>T; p.R278*; 4:95245088-95245088	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.224A>T; p.K75M; 4:95335532-95335532	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1801C>T; p.L601F; 4:95206729-95206729	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.960G>A; p.T320T; 4:95242577-95242577	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1022C>T; p.T341M; 4:95242515-95242515	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1883C>T; p.A628V; 4:95206647-95206647	oesophagus	carcinoma	Substitution - Missense
c.1350A>C; p.R450S; 4:95219264-95219264	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.529G>A; p.E177K; 4:95278324-95278324	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1722A>T; p.K574N; 4:95216135-95216135	pancreas	carcinoma	Substitution - Missense
c.1722A>T; p.K574N; 4:95216135-95216135	pancreas	carcinoma	Substitution - Missense
c.2795A>G; p.932; 4:95169235-95169235	large_intestine; caecum	adenoma	Substitution - coding silent
c.1400A>C; p.N467T; 4:95219214-95219214	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.809C>T; p.S270F; 4:95245111-95245111	skin	malignant_melanoma	Substitution - Missense
c.1303C>A; p.L435M; 4:95219311-95219311	oesophagus	carcinoma	Substitution - Missense
c.1587C>T; p.S529S; 4:95219027-95219027	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1587C>T; p.S529S; 4:95219027-95219027	skin	malignant_melanoma	Substitution - coding silent
c.1619G>A; p.G540E; 4:95218995-95218995	skin	malignant_melanoma	Substitution - Missense
c.2103C>A; p.V701V; 4:95202764-95202764	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1370A>G; p.H457R; 4:95219244-95219244	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.500A>C; p.K167T; 4:95278353-95278353	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.830G>T; p.G277V; 4:95245090-95245090	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1250C>T; p.S417L; 4:95220035-95220035	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1065C>A; p.L355L; 4:95242472-95242472	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2112G>C; p.L704L; 4:95202755-95202755	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1807C>T; p.R603C; 4:95206723-95206723	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1088C>T; p.T363I; 4:95242449-95242449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1164C>T; p.I388I; 4:95220121-95220121	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1651A>G; p.S551G; 4:95216206-95216206	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.848G>A; p.R283H; 4:95245072-95245072	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1359C>A; p.V453V; 4:95219255-95219255	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.848G>A; p.R283H; 4:95245072-95245072	skin	malignant_melanoma	Substitution - Missense
c.1675A>G; p.I559V; 4:95216182-95216182	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1718G>A; p.R573K; 4:95216139-95216139	skin	malignant_melanoma	Substitution - Missense
c.2490G>A; p.A830A; 4:95170294-95170294	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.921A>G; p.I307M; 4:95244999-95244999	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1977C>A; p.I659I; 4:95202890-95202890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2490G>A; p.A830A; 4:95170294-95170294	skin	malignant_melanoma	Substitution - coding silent
c.640C>T; p.R214W; 4:95250622-95250622	skin	malignant_melanoma	Substitution - Missense
c.1445A>G; p.Y482C; 4:95219169-95219169	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2117A>T; p.D706V; 4:95202750-95202750	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.748A>G; p.S250G; 4:95250514-95250514	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.369C>T; p.S123S; 4:95301727-95301727	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2003C>T; p.A668V; 4:95202864-95202864	skin	malignant_melanoma	Substitution - Missense
c.2042G>A; p.R681H; 4:95202825-95202825	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2042G>A; p.R681H; 4:95202825-95202825	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.2003C>T; p.A668V; 4:95202864-95202864	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.467G>A; p.R156Q; 4:95301629-95301629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1582C>A; p.P528T; 4:95219032-95219032	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2287G>A; p.E763K; 4:95183061-95183061	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.583C>T; p.P195S; 4:95278270-95278270	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2044C>T; p.L682F; 4:95202823-95202823	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1427A>G; p.N476S; 4:95219187-95219187	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.117C>T; p.A39A; 4:95548741-95548741	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.558C>T; p.L186L; 4:95278295-95278295	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1683A>T; p.Q561H; 4:95216174-95216174	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1471delC; p.Q491fs*15; 4:95219143-95219143	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1429C>T; p.L477L; 4:95219185-95219185	liver	carcinoma	Substitution - coding silent
c.1429C>T; p.L477L; 4:95219185-95219185	liver	carcinoma	Substitution - coding silent
c.2197C>A; p.H733N; 4:95185136-95185136	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1262G>T; p.G421V; 4:95220023-95220023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1205A>T; p.Y402F; 4:95220080-95220080	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2485C>T; p.P829S; 4:95170299-95170299	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2396T>C; p.V799A; 4:95182952-95182952	oesophagus	carcinoma	Substitution - Missense
c.1665C>T; p.P555P; 4:95216192-95216192	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1470C>A; p.P490P; 4:95219144-95219144	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.473C>T; p.A158V; 4:95301623-95301623	central_nervous_system; brain	glioma	Substitution - Missense
c.1919G>A; p.G640E; 4:95202948-95202948	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2101G>A; p.V701I; 4:95202766-95202766	breast	carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]