| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 8711 |
Name | TNK1 |
Synonymous | tyrosine kinase, non-receptor, 1;TNK1;tyrosine kinase, non-receptor, 1 |
Definition | CD38 negative kinase 1|non-receptor tyrosine-protein kinase TNK1 |
Position | 17p13.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.12. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.402G>A; p.L134L; 17:7383592-7383592 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.953C>T; p.S318F; 17:7384570-7384570 |
skin | malignant_melanoma | Substitution - Missense |
c.293G>A; p.R98Q; 17:7383483-7383483 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1965C>A; p.L655L; 17:7389048-7389048 |
large_intestine; colon | NS | Substitution - coding silent |
c.1149G>A; p.S383S; 17:7386572-7386572 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.219G>T; p.K73N; 17:7383305-7383305 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.471G>A; p.P157P; 17:7383753-7383753 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1711G>C; p.G571R; 17:7388624-7388624 |
pancreas | NS | Substitution - Missense |
c.1131G>T; p.L377L; 17:7384748-7384748 |
breast | carcinoma | Substitution - coding silent |
c.1702C>T; p.H568Y; 17:7388615-7388615 |
upper_aerodigestive_tract; mouth | carcinoma | Substitution - Missense |
c.1702C>T; p.H568Y; 17:7388615-7388615 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.921G>A; p.W307*; 17:7384538-7384538 |
oesophagus | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.1675T>C; p.W559R; 17:7388588-7388588 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.85G>A; p.E29K; 17:7383011-7383011 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.1024C>T; p.L342L; 17:7384641-7384641 |
oesophagus; middle_third | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1824_1825GG>AA; p.E609K; 17:7388820-7388821 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1685G>T; p.R562I; 17:7388598-7388598 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1515A>G; p.S505S; 17:7388428-7388428 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.844C>G; p.P282A; 17:7384231-7384231 |
thyroid | other; neoplasm | Substitution - Missense |
c.43C>T; p.R15W; 17:7382969-7382969 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1761C>T; p.S587S; 17:7388674-7388674 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1282C>T; p.R428C; 17:7387024-7387024 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1535G>A; p.R512H; 17:7388448-7388448 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1072C>T; p.R358C; 17:7384689-7384689 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.312delG; p.G106fs*5; 17:7383502-7383502 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1638T>G; p.S546S; 17:7388551-7388551 |
liver | carcinoma | Substitution - coding silent |
c.1638T>G; p.S546S; 17:7388551-7388551 |
liver | carcinoma | Substitution - coding silent |
c.705C>T; p.Y235Y; 17:7384092-7384092 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.966A>C; p.E322D; 17:7384583-7384583 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.468C>T; p.G156G; 17:7383750-7383750 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.200G>A; p.R67H; 17:7383286-7383286 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1453C>T; p.R485W; 17:7387418-7387418 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1453C>T; p.R485W; 17:7387418-7387418 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.951C>A; p.F317L; 17:7384568-7384568 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.570G>T; p.Q190H; 17:7383852-7383852 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1677G>A; p.W559*; 17:7388590-7388590 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1344G>A; p.L448L; 17:7387086-7387086 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1650C>A; p.S550R; 17:7388563-7388563 |
large_intestine; colon | NS | Substitution - Missense |
c.289C>T; p.P97S; 17:7383479-7383479 |
skin | malignant_melanoma | Substitution - Missense |
c.1323G>A; p.T441T; 17:7387065-7387065 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1455G>A; p.R485R; 17:7387420-7387420 |
skin | malignant_melanoma | Substitution - coding silent |
c.1100G>A; p.R367Q; 17:7384717-7384717 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.935C>T; p.T312M; 17:7384552-7384552 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1432C>A; p.L478I; 17:7387397-7387397 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1338G>A; p.G446G; 17:7387080-7387080 |
skin | malignant_melanoma | Substitution - coding silent |
c.1099C>T; p.R367W; 17:7384716-7384716 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.848G>A; p.R283H; 17:7384235-7384235 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1686A>C; p.R562S; 17:7388599-7388599 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.738C>T; p.L246L; 17:7384125-7384125 |
ovary | other; neoplasm | Substitution - coding silent |
c.1493G>A; p.G498D; 17:7388406-7388406 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1224C>T; p.I408I; 17:7386647-7386647 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1224C>T; p.I408I; 17:7386647-7386647 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1224C>T; p.I408I; 17:7386647-7386647 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.189G>A; p.L63L; 17:7383275-7383275 |
breast | carcinoma | Substitution - coding silent |
c.1016G>A; p.R339K; 17:7384633-7384633 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1016G>A; p.R339K; 17:7384633-7384633 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1587G>A; p.V529V; 17:7388500-7388500 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.892G>A; p.G298R; 17:7384509-7384509 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1782G>A; p.K594K; 17:7388695-7388695 |
skin | malignant_melanoma | Substitution - coding silent |
c.1089C>G; p.H363Q; 17:7384706-7384706 |
liver | carcinoma | Substitution - Missense |
c.21C>T; p.S7S; 17:7382947-7382947 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.21C>T; p.S7S; 17:7382947-7382947 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.1762G>A; p.D588N; 17:7388675-7388675 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1762G>T; p.D588Y; 17:7388675-7388675 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.712G>A; p.A238T; 17:7384099-7384099 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1314G>A; p.S438S; 17:7387056-7387056 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1442C>T; p.A481V; 17:7387407-7387407 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1735G>A; p.A579T; 17:7388648-7388648 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1413-2A>G; p.?; 17:7387376-7387376 |
liver | carcinoma; hepatocellular_carcinoma | Unknown |
c.1413-2A>G; p.?; 17:7387376-7387376 |
large_intestine; colon | carcinoma; adenocarcinoma | Unknown |