| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 8784 |
Name | TNFRSF18 |
Synonymous | tumor necrosis factor receptor superfamily, member 18;TNFRSF18;tumor necrosis factor receptor superfamily, member 18 |
Definition | TNF receptor superfamily activation-inducible protein|activation-inducible TNFR family receptor|glucocorticoid-induced TNFR-related protein|tumor necrosis factor receptor superfamily member 18 |
Position | 1p36.3 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.00. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.363C>T; p.S121S; 1:1204434-1204434 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.397G>T; p.D133Y; 1:1204400-1204400 |
thyroid | other; neoplasm | Substitution - Missense |
c.671G>T; p.C224F; 1:1203688-1203688 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - Missense |
c.306C>T; p.S102S; 1:1205374-1205374 |
skin | malignant_melanoma | Substitution - coding silent |
c.269G>A; p.R90Q; 1:1205411-1205411 |
pancreas | carcinoma | Substitution - Missense |
c.224T>C; p.V75A; 1:1205456-1205456 |
ovary | other; neoplasm | Substitution - Missense |
c.188-3C>T; p.?; 1:1205495-1205495 |
NS | malignant_melanoma | Unknown |
c.188-3C>T; p.?; 1:1205495-1205495 |
NS | malignant_melanoma | Unknown |
c.283C>T; p.P95S; 1:1205397-1205397 |
skin | malignant_melanoma | Substitution - Missense |
c.378C>T; p.G126G; 1:1204419-1204419 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.367G>A; p.G123S; 1:1204430-1204430 |
skin | malignant_melanoma | Substitution - Missense |
c.373G>A; p.E125K; 1:1204424-1204424 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.285C>T; p.P95P; 1:1205395-1205395 |
skin | malignant_melanoma | Substitution - coding silent |
c.616C>T; p.P206S; 1:1203743-1203743 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.350C>A; p.S117*; 1:1204447-1204447 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.326G>A; p.G109D; 1:1204471-1204471 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.537A>G; p.P179P; 1:1203822-1203822 |
breast | carcinoma | Substitution - coding silent |
c.537A>G; p.P179P; 1:1203822-1203822 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.475C>T; p.R159W; 1:1203884-1203884 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.731delC; p.P244fs*>12; 1:1203628-1203628 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.176G>A; p.R59H; 1:1206396-1206396 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |