Entrez Gene

Basic Information
Gene ID	8821
Name	INPP4B
Synonymous	inositol polyphosphate-4-phosphatase, type II, 105kDa;INPP4B;inositol polyphosphate-4-phosphatase, type II, 105kDa
Definition	inositol polyphosphate 4-phosphatase II; 4-phosphatase II\|inositol polyphosphate 4-phosphatase type II\|inositol polyphosphate-4-phosphatase, type II, 105kD\|type II inositol 3,4-bisphosphate 4-phosphatase\|type II inositol-3,4-bisphosphate 4-phosphatase
Position	4q31.21
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.16.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1399A>T; p.R467W; 4:142160522-142160522	thyroid	other; neoplasm	Substitution - Missense
c.2370T>C; p.P790P; 4:142108097-142108097	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.89C>T; p.T30I; 4:142431171-142431171	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.968-1G>T; p.?; 4:142208530-142208530	lung	carcinoma; adenocarcinoma	Unknown
c.1619A>G; p.D540G; 4:142145941-142145941	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1386G>A; p.K462K; 4:142160535-142160535	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.658G>A; p.G220R; 4:142260522-142260522	breast	carcinoma	Substitution - Missense
c.1167A>C; p.E389D; 4:142193101-142193101	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2549C>T; p.S850L; 4:142082124-142082124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1522G>A; p.D508N; 4:142160399-142160399	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1839C>A; p.S613R; 4:142124642-142124642	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1570G>A; p.V524M; 4:142145990-142145990	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2357A>G; p.E786G; 4:142108110-142108110	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2357A>G; p.E786G; 4:142108110-142108110	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.30A>G; p.E10E; 4:142431230-142431230	skin	malignant_melanoma	Substitution - coding silent
c.407C>T; p.P136L; 4:142314728-142314728	skin	malignant_melanoma	Substitution - Missense
c.407C>T; p.P136L; 4:142314728-142314728	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1675G>A; p.E559K; 4:142145885-142145885	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2648G>T; p.G883V; 4:142028909-142028909	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2276G>A; p.R759K; 4:142112542-142112542	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2746G>C; p.E916Q; 4:142028811-142028811	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1187delG; p.G396fs*29; 4:142173804-142173804	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.2726C>A; p.P909H; 4:142028831-142028831	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2146G>A; p.V716M; 4:142112672-142112672	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2453_2454insA; p.N820fs*24; 4:142086177-142086178	skin; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.2427C>A; p.L809L; 4:142086204-142086204	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2238T>C; p.F746F; 4:142112580-142112580	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2621G>T; p.R874L; 4:142082052-142082052	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.744G>A; p.W248*; 4:142237956-142237956	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.438C>T; p.G146G; 4:142305523-142305523	breast	carcinoma	Substitution - coding silent
c.692T>C; p.L231S; 4:142238008-142238008	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1820T>C; p.L607P; 4:142124661-142124661	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1203C>A; p.Y401*; 4:142173788-142173788	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.353A>T; p.K118M; 4:142402957-142402957	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1332G>C; p.K444N; 4:142173659-142173659	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1332G>C; p.K444N; 4:142173659-142173659	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2268G>A; p.L756L; 4:142112550-142112550	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1302T>C; p.S434S; 4:142173689-142173689	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2487+8C>A; p.?; 4:142086136-142086136	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Unknown
c.388C>T; p.L130L; 4:142314747-142314747	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.743_744GG>CA; p.W248S; 4:142237956-142237957	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2218C>T; p.H740Y; 4:142112600-142112600	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1643G>T; p.G548V; 4:142145917-142145917	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1303G>T; p.A435S; 4:142173688-142173688	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1054C>T; p.H352Y; 4:142208443-142208443	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2060C>T; p.S687F; 4:142122203-142122203	liver	carcinoma	Substitution - Missense
c.2060C>T; p.S687F; 4:142122203-142122203	liver	carcinoma	Substitution - Missense
c.1056C>T; p.H352H; 4:142208441-142208441	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.689-2A>G; p.?; 4:142238013-142238013	lung; right_lower_lobe	carcinoma; adenocarcinoma	Unknown
c.1394T>C; p.L465P; 4:142160527-142160527	thyroid	other; neoplasm	Substitution - Missense
c.869C>A; p.S290Y; 4:142208994-142208994	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1949C>A; p.P650Q; 4:142123360-142123360	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.748C>T; p.R250*; 4:142237952-142237952	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.748C>T; p.R250*; 4:142237952-142237952	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.748C>T; p.R250*; 4:142237952-142237952	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.582C>T; p.A194A; 4:142270696-142270696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.748C>T; p.R250*; 4:142237952-142237952	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.178A>C; p.N60H; 4:142405283-142405283	ovary	other; neoplasm	Substitution - Missense
c.972C>T; p.S324S; 4:142208525-142208525	skin	malignant_melanoma	Substitution - coding silent
c.366T>C; p.H122H; 4:142402944-142402944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.178A>C; p.N60H; 4:142405283-142405283	ovary	other; neoplasm	Substitution - Missense
c.1395T>G; p.L465L; 4:142160526-142160526	thyroid	other; neoplasm	Substitution - coding silent
c.23C>T; p.A8V; 4:142431237-142431237	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2689A>C; p.K897Q; 4:142028868-142028868	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2322C>T; p.F774F; 4:142108145-142108145	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2322C>T; p.F774F; 4:142108145-142108145	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1980G>T; p.G660G; 4:142123329-142123329	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.76G>C; p.D26H; 4:142431184-142431184	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1066T>A; p.L356M; 4:142208431-142208431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2495G>A; p.R832H; 4:142082178-142082178	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.991A>T; p.S331C; 4:142208506-142208506	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1332G>T; p.K444N; 4:142173659-142173659	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1661G>A; p.G554D; 4:142145899-142145899	breast	carcinoma	Substitution - Missense
c.2464G>A; p.E822K; 4:142086167-142086167	urinary_tract; bladder	carcinoma	Substitution - Missense
c.558G>T; p.M186I; 4:142270720-142270720	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1127T>A; p.F376Y; 4:142193141-142193141	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1616T>C; p.V539A; 4:142145944-142145944	pancreas	carcinoma	Substitution - Missense
c.1616T>C; p.V539A; 4:142145944-142145944	pancreas	carcinoma	Substitution - Missense
c.1616T>C; p.V539A; 4:142145944-142145944	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1616T>C; p.V539A; 4:142145944-142145944	pancreas	carcinoma	Substitution - Missense
c.469A>G; p.K157E; 4:142305492-142305492	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.890G>A; p.R297Q; 4:142208973-142208973	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1688C>A; p.S563*; 4:142145872-142145872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.643C>A; p.P215T; 4:142260537-142260537	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1145G>A; p.R382Q; 4:142193123-142193123	breast	carcinoma	Substitution - Missense
c.2587_2588delGA; p.D863fs*1; 4:142082085-142082086	liver	carcinoma	Deletion - Frameshift
c.2576C>G; p.S859*; 4:142082097-142082097	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2419G>T; p.E807*; 4:142086212-142086212	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2015A>G; p.Y672C; 4:142123294-142123294	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1061C>T; p.P354L; 4:142208436-142208436	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.2188C>A; p.P730T; 4:142112630-142112630	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.1541C>T; p.S514L; 4:142160380-142160380	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.616-1G>A; p.?; 4:142260565-142260565	breast	carcinoma	Unknown
c.650G>T; p.S217I; 4:142260530-142260530	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2375-10T>C; p.?; 4:142086266-142086266	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.853G>T; p.E285*; 4:142209010-142209010	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1098G>A; p.V366V; 4:142193170-142193170	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.853G>T; p.E285*; 4:142209010-142209010	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.447T>C; p.S149S; 4:142305514-142305514	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1833G>A; p.A611A; 4:142124648-142124648	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.417A>C; p.E139D; 4:142314718-142314718	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.968G>T; p.G323V; 4:142208529-142208529	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2323G>A; p.E775K; 4:142108144-142108144	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2488-1G>C; p.?; 4:142082186-142082186	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1083C>T; p.Y361Y; 4:142193185-142193185	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2323G>A; p.E775K; 4:142108144-142108144	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1039C>G; p.Q347E; 4:142208458-142208458	breast	carcinoma	Substitution - Missense
c.1789C>T; p.R597*; 4:142124692-142124692	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Nonsense
c.2323G>A; p.E775K; 4:142108144-142108144	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1745C>T; p.P582L; 4:142124736-142124736	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.643C>T; p.P215S; 4:142260537-142260537	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.115C>T; p.P39S; 4:142429194-142429194	lung	carcinoma; mixed_small_cell_carcinoma-adenocarcinoma	Substitution - Missense
c.2550G>A; p.S850S; 4:142082123-142082123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2363T>A; p.M788K; 4:142108104-142108104	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1376A>T; p.H459L; 4:142160545-142160545	prostate	carcinoma	Substitution - Missense
c.2550G>A; p.S850S; 4:142082123-142082123	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1884C>T; p.F628F; 4:142124597-142124597	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.882delC; p.D294fs*15; 4:142208981-142208981	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2652C>A; p.C884*; 4:142028905-142028905	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.34G>A; p.G12R; 4:142431226-142431226	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.583G>A; p.D195N; 4:142270695-142270695	central_nervous_system; brain	glioma	Substitution - Missense
c.1227A>C; p.K409N; 4:142173764-142173764	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1630G>A; p.E544K; 4:142145930-142145930	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2452_2453insA; p.R818fs*26; 4:142086178-142086179	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.310A>G; p.I104V; 4:142403000-142403000	liver	carcinoma	Substitution - Missense
c.310A>G; p.I104V; 4:142403000-142403000	liver	carcinoma	Substitution - Missense
c.310A>G; p.I104V; 4:142403000-142403000	liver	carcinoma	Substitution - Missense
c.310A>G; p.I104V; 4:142403000-142403000	liver	carcinoma	Substitution - Missense
c.1137T>C; p.G379G; 4:142193131-142193131	liver	carcinoma	Substitution - coding silent
c.1137T>C; p.G379G; 4:142193131-142193131	liver	carcinoma	Substitution - coding silent
c.1782G>A; p.V594V; 4:142124699-142124699	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.415G>A; p.E139K; 4:142314720-142314720	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1714C>T; p.P572S; 4:142145846-142145846	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1069A>T; p.K357*; 4:142208428-142208428	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2637G>A; p.M879I; 4:142082036-142082036	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1471A>G; p.S491G; 4:142160450-142160450	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2380T>C; p.S794P; 4:142086251-142086251	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1587_1588insG; p.K530fs*15; 4:142145972-142145973	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.548T>C; p.V183A; 4:142270730-142270730	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.660A>C; p.G220G; 4:142260520-142260520	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1270A>C; p.I424L; 4:142173721-142173721	breast	carcinoma	Substitution - Missense
c.1396G>A; p.V466I; 4:142160525-142160525	thyroid	other; neoplasm	Substitution - Missense
c.2425C>A; p.L809I; 4:142086206-142086206	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2425C>A; p.L809I; 4:142086206-142086206	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1687T>C; p.S563P; 4:142145873-142145873	liver	carcinoma	Substitution - Missense
c.376C>T; p.R126*; 4:142314759-142314759	skin	malignant_melanoma	Substitution - Nonsense
c.743G>C; p.W248S; 4:142237957-142237957	urinary_tract; bladder	carcinoma	Substitution - Missense
c.641C>A; p.A214D; 4:142260539-142260539	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2696C>T; p.A899V; 4:142028861-142028861	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2696C>T; p.A899V; 4:142028861-142028861	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2743C>T; p.P915S; 4:142028814-142028814	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1092C>T; p.I364I; 4:142193176-142193176	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.730T>C; p.S244P; 4:142237970-142237970	liver	carcinoma	Substitution - Missense
c.225G>A; p.L75L; 4:142405236-142405236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1475C>T; p.T492I; 4:142160446-142160446	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2172A>C; p.R724S; 4:142112646-142112646	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2329C>G; p.L777V; 4:142108138-142108138	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1205A>G; p.Y402C; 4:142173786-142173786	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.133C>T; p.L45F; 4:142429176-142429176	skin	malignant_melanoma	Substitution - Missense
c.500T>C; p.L167P; 4:142305461-142305461	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2382A>G; p.S794S; 4:142086249-142086249	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1960C>G; p.Q654E; 4:142123349-142123349	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1338T>C; p.S446S; 4:142173653-142173653	liver	carcinoma	Substitution - coding silent
c.1338T>C; p.S446S; 4:142173653-142173653	liver	carcinoma	Substitution - coding silent
c.1338T>C; p.S446S; 4:142173653-142173653	liver	carcinoma	Substitution - coding silent
c.112G>A; p.E38K; 4:142429197-142429197	skin	malignant_melanoma	Substitution - Missense
c.347A>G; p.D116G; 4:142402963-142402963	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2355G>T; p.M785I; 4:142108112-142108112	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1290A>G; p.L430L; 4:142173701-142173701	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.340G>T; p.V114F; 4:142402970-142402970	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1964A>T; p.Q655L; 4:142123345-142123345	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.714A>T; p.L238F; 4:142237986-142237986	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1316C>T; p.S439F; 4:142173675-142173675	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.2654G>A; p.R885H; 4:142028903-142028903	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.2654G>A; p.R885H; 4:142028903-142028903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1526C>T; p.S509F; 4:142160395-142160395	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.315T>C; p.Y105Y; 4:142402995-142402995	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2102C>A; p.S701Y; 4:142122161-142122161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1764G>T; p.K588N; 4:142124717-142124717	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2062G>T; p.D688Y; 4:142122201-142122201	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1902A>G; p.G634G; 4:142123407-142123407	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1296T>C; p.L432L; 4:142173695-142173695	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.377G>A; p.R126Q; 4:142314758-142314758	breast	carcinoma	Substitution - Missense
c.1643G>A; p.G548D; 4:142145917-142145917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1361C>G; p.T454R; 4:142160560-142160560	liver	carcinoma	Substitution - Missense
c.1361C>G; p.T454R; 4:142160560-142160560	liver	carcinoma	Substitution - Missense
c.1361C>G; p.T454R; 4:142160560-142160560	liver	carcinoma	Substitution - Missense
c.1361C>G; p.T454R; 4:142160560-142160560	liver	carcinoma	Substitution - Missense
c.1806G>C; p.L602L; 4:142124675-142124675	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.889C>T; p.R297*; 4:142208974-142208974	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1046T>C; p.M349T; 4:142208451-142208451	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.619G>T; p.A207S; 4:142260561-142260561	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.377G>C; p.R126P; 4:142314758-142314758	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.157C>T; p.P53S; 4:142405304-142405304	skin; trunk	malignant_melanoma	Substitution - Missense
c.1509G>A; p.V503V; 4:142160412-142160412	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2019C>T; p.S673S; 4:142122244-142122244	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1548T>C; p.Y516Y; 4:142160373-142160373	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1203C>T; p.Y401Y; 4:142173788-142173788	central_nervous_system; brain	glioma	Substitution - coding silent
c.55G>A; p.A19T; 4:142431205-142431205	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.55G>A; p.A19T; 4:142431205-142431205	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1972A>T; p.T658S; 4:142123337-142123337	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2456A>T; p.K819M; 4:142086175-142086175	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.244G>A; p.E82K; 4:142405217-142405217	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.713T>G; p.L238*; 4:142237987-142237987	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2076T>C; p.V692V; 4:142122187-142122187	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.116C>A; p.P39Q; 4:142429193-142429193	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1186G>A; p.G396R; 4:142173805-142173805	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1584_1585insT; p.G529fs*16; 4:142145975-142145976	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2155G>T; p.V719F; 4:142112663-142112663	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.369C>T; p.D123D; 4:142402941-142402941	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.369C>T; p.D123D; 4:142402941-142402941	thyroid	other; neoplasm	Substitution - coding silent
c.2077G>A; p.A693T; 4:142122186-142122186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.893A>C; p.K298T; 4:142208970-142208970	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2457G>C; p.K819N; 4:142086174-142086174	breast	carcinoma	Substitution - Missense
c.2020G>T; p.D674Y; 4:142122243-142122243	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.20G>T; p.G7V; 4:142431240-142431240	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.671T>C; p.L224S; 4:142260509-142260509	thyroid	carcinoma; medullary_carcinoma	Substitution - Missense
c.749G>A; p.R250Q; 4:142237951-142237951	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1141C>T; p.L381F; 4:142193127-142193127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749G>A; p.R250Q; 4:142237951-142237951	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

Top

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

Loss of Function mutations compare to missense mutations

Top

The copy number variations for various cancers

Top

COSMIC somatic mutation [Top]