Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

8838

Name

WISP3

Synonymous

WNT1 inducible signaling pathway protein 3;WISP3;WNT1 inducible signaling pathway protein 3

Definition

CCN family member 6|WNT1-inducible-signaling pathway protein 3

Position

6q21

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.30.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.460C>T; p.Q154*; 6:112064814-112064814

 skinmalignant_melanomaSubstitution - Nonsense

c.1070G>T; p.R357I; 6:112069571-112069571

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1070G>T; p.R357I; 6:112069571-112069571

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.474G>T; p.L158F; 6:112064828-112064828

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.14G>A; p.R5Q; 6:112054317-112054317

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.29C>T; p.S10L; 6:112054332-112054332

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.316G>T; p.E106*; 6:112061204-112061204

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.316G>T; p.E106*; 6:112061204-112061204

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.564T>G; p.G188G; 6:112064918-112064918

 breastcarcinomaSubstitution - coding silent

c.698A>C; p.K233T; 6:112068259-112068259

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.698A>C; p.K233T; 6:112068259-112068259

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.781G>C; p.E261Q; 6:112068342-112068342

 breastcarcinomaSubstitution - Missense

c.909C>T; p.C303C; 6:112069410-112069410

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.122G>A; p.G41D; 6:112061010-112061010

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.861A>G; p.Q287Q; 6:112069362-112069362

 thyroidother; neoplasmSubstitution - coding silent

c.861A>G; p.Q287Q; 6:112069362-112069362

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.256G>A; p.V86M; 6:112061144-112061144

 breastcarcinomaSubstitution - Missense

c.811G>A; p.D271N; 6:112068372-112068372

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.811G>A; p.D271N; 6:112068372-112068372

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.631A>G; p.K211E; 6:112064985-112064985

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.151G>A; p.G51R; 6:112061039-112061039

 skinmalignant_melanomaSubstitution - Missense

c.345G>T; p.G115G; 6:112061233-112061233

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.570G>A; p.K190K; 6:112064924-112064924

 skinmalignant_melanomaSubstitution - coding silent

c.414T>C; p.V138V; 6:112064768-112064768

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.577G>T; p.D193Y; 6:112064931-112064931

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1064G>A; p.C355Y; 6:112069565-112069565

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.422A>G; p.E141G; 6:112064776-112064776

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.422A>G; p.E141G; 6:112064776-112064776

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.933C>T; p.P311P; 6:112069434-112069434

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.919C>G; p.Q307E; 6:112069420-112069420

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.919C>G; p.Q307E; 6:112069420-112069420

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.572A>C; p.K191T; 6:112064926-112064926

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.88G>T; p.A30S; 6:112054391-112054391

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.590G>A; p.C197Y; 6:112064944-112064944

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.272G>T; p.G91V; 6:112061160-112061160

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.600A>G; p.E200E; 6:112064954-112064954

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.874C>G; p.L292V; 6:112069375-112069375

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.535G>T; p.A179S; 6:112064889-112064889

 prostatecarcinomaSubstitution - Missense

c.669_670insA; p.C227fs*21; 6:112068230-112068231

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.669_670insA; p.C227fs*21; 6:112068230-112068231

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.294G>T; p.K98N; 6:112061182-112061182

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.294G>T; p.K98N; 6:112061182-112061182

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.788G>A; p.R263K; 6:112068349-112068349

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.237C>A; p.C79*; 6:112061125-112061125

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.40C>T; p.H14Y; 6:112054343-112054343

 skinmalignant_melanomaSubstitution - Missense

c.791T>C; p.L264P; 6:112068352-112068352

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.570G>T; p.K190N; 6:112064924-112064924

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.722G>A; p.C241Y; 6:112068283-112068283

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.163G>T; p.E55*; 6:112061051-112061051

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.163G>T; p.E55*; 6:112061051-112061051

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.163G>T; p.E55*; 6:112061051-112061051

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.670delA; p.K226fs*24; 6:112068231-112068231

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.670delA; p.K226fs*24; 6:112068231-112068231

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.102+1G>T; p.?; 6:112054406-112054406

 livercarcinoma; hepatocellular_carcinomaUnknown

c.670delA; p.K226fs*24; 6:112068231-112068231

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.670delA; p.K226fs*24; 6:112068231-112068231

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.670delA; p.K226fs*24; 6:112068231-112068231

 skinmalignant_melanomaDeletion - Frameshift

c.670delA; p.K226fs*24; 6:112068231-112068231

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.670delA; p.K226fs*24; 6:112068231-112068231

 oesophagus; lower_thirdcarcinoma; adenocarcinomaDeletion - Frameshift

c.539G>A; p.G180D; 6:112064893-112064893

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.306A>C; p.E102D; 6:112061194-112061194

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.449G>A; p.G150D; 6:112064803-112064803

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.513A>C; p.T171T; 6:112064867-112064867

 breastcarcinomaSubstitution - coding silent

c.253C>T; p.L85L; 6:112061141-112061141

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.679T>A; p.C227S; 6:112068240-112068240

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.260G>A; p.R87K; 6:112061148-112061148

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.548G>T; p.C183F; 6:112064902-112064902

 skinmalignant_melanomaSubstitution - Missense

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