Entrez Gene

Basic Information
Gene ID	8864
Name	PER2
Synonymous	period circadian clock 2;PER2;period circadian clock 2
Definition	circadian clock protein PERIOD 2\|hPER2\|period 2\|period circadian protein 2\|period circadian protein homolog 2\|period homolog 2
Position	2q37.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.01.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.934C>T; p.L312L; 2:238268089-238268089	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3505C>T; p.L1169L; 2:238249175-238249175	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3686C>T; p.S1229F; 2:238246457-238246457	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.400A>G; p.T134A; 2:238275791-238275791	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1993T>C; p.S665P; 2:238256994-238256994	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1993T>C; p.S665P; 2:238256994-238256994	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1894G>T; p.A632S; 2:238258282-238258282	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3601G>A; p.A1201T; 2:238249079-238249079	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1093C>T; p.P365S; 2:238263012-238263012	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2838G>C; p.Q946H; 2:238253185-238253185	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.282A>G; p.T94T; 2:238277142-238277142	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2455G>A; p.A819T; 2:238253568-238253568	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1192A>G; p.I398V; 2:238262306-238262306	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2861C>T; p.S954L; 2:238253162-238253162	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3451T>C; p.Y1151H; 2:238250567-238250567	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2347G>A; p.G783R; 2:238253676-238253676	breast	carcinoma	Substitution - Missense
c.3059C>T; p.A1020V; 2:238252964-238252964	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2047A>C; p.K683Q; 2:238256940-238256940	kidney	other; neoplasm	Substitution - Missense
c.578T>C; p.F193S; 2:238271506-238271506	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.569C>T; p.A190V; 2:238273071-238273071	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3584A>G; p.Q1195R; 2:238249096-238249096	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3449C>T; p.T1150M; 2:238250569-238250569	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.256G>A; p.A86T; 2:238277168-238277168	central_nervous_system; brain	glioma	Substitution - Missense
c.2776C>T; p.P926S; 2:238253247-238253247	skin	malignant_melanoma	Substitution - Missense
c.621C>T; p.I207I; 2:238271463-238271463	skin	malignant_melanoma	Substitution - coding silent
c.3562C>T; p.R1188C; 2:238249118-238249118	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3562C>T; p.R1188C; 2:238249118-238249118	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3733T>A; p.S1245T; 2:238246410-238246410	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.33C>T; p.P11P; 2:238277904-238277904	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1540G>T; p.A514S; 2:238260830-238260830	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2464C>T; p.P822S; 2:238253559-238253559	skin	malignant_melanoma	Substitution - Missense
c.2464C>T; p.P822S; 2:238253559-238253559	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1944T>C; p.G648G; 2:238257043-238257043	breast	carcinoma	Substitution - coding silent
c.1474G>A; p.E492K; 2:238260896-238260896	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.564G>A; p.K188K; 2:238273076-238273076	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2252T>C; p.L751P; 2:238255725-238255725	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3731G>A; p.G1244E; 2:238246412-238246412	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.798G>A; p.E266E; 2:238268949-238268949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.895C>T; p.R299W; 2:238268128-238268128	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.542T>A; p.V181D; 2:238273098-238273098	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2114C>T; p.A705V; 2:238255863-238255863	breast	carcinoma	Substitution - Missense
c.1204G>T; p.A402S; 2:238262294-238262294	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.709G>A; p.G237S; 2:238271375-238271375	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.13G>A; p.A5T; 2:238277924-238277924	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.13G>A; p.A5T; 2:238277924-238277924	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.3464C>T; p.S1155F; 2:238250554-238250554	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2139C>T; p.L713L; 2:238255838-238255838	breast	carcinoma	Substitution - coding silent
c.735G>A; p.P245P; 2:238271349-238271349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2816C>T; p.S939F; 2:238253207-238253207	skin	malignant_melanoma	Substitution - Missense
c.2269C>T; p.H757Y; 2:238255708-238255708	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1992G>A; p.A664A; 2:238256995-238256995	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1992G>A; p.A664A; 2:238256995-238256995	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1992G>A; p.A664A; 2:238256995-238256995	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1175C>G; p.P392R; 2:238262323-238262323	pancreas	carcinoma	Substitution - Missense
c.3102G>A; p.A1034A; 2:238252921-238252921	breast	carcinoma	Substitution - coding silent
c.3145G>A; p.A1049T; 2:238251728-238251728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3145G>A; p.A1049T; 2:238251728-238251728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2116G>T; p.G706C; 2:238255861-238255861	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1864C>T; p.R622W; 2:238258312-238258312	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.107G>A; p.S36N; 2:238277830-238277830	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1703C>T; p.P568L; 2:238258569-238258569	skin	malignant_melanoma	Substitution - Missense
c.2048A>C; p.K683T; 2:238256939-238256939	kidney	other; neoplasm	Substitution - Missense
c.2564C>T; p.S855L; 2:238253459-238253459	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1258C>T; p.P420S; 2:238262240-238262240	breast	carcinoma	Substitution - Missense
c.55G>A; p.V19M; 2:238277882-238277882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.770C>T; p.A257V; 2:238271314-238271314	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3253G>A; p.D1085N; 2:238251620-238251620	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.3403C>T; p.P1135S; 2:238250615-238250615	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487G>A; p.G163S; 2:238273153-238273153	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2857A>C; p.T953P; 2:238253166-238253166	urinary_tract; bladder	carcinoma	Substitution - Missense
c.989delA; p.K330fs*32; 2:238265569-238265569	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2433C>T; p.T811T; 2:238253590-238253590	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.383C>A; p.A128D; 2:238275808-238275808	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2433C>T; p.T811T; 2:238253590-238253590	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.2433C>T; p.T811T; 2:238253590-238253590	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1757G>T; p.C586F; 2:238258515-238258515	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.308C>T; p.S103L; 2:238275883-238275883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.22C>T; p.P8S; 2:238277915-238277915	skin	malignant_melanoma	Substitution - Missense
c.932T>G; p.L311R; 2:238268091-238268091	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1196G>A; p.R399Q; 2:238262302-238262302	pancreas	carcinoma	Substitution - Missense
c.2467C>G; p.L823V; 2:238253556-238253556	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1173G>T; p.Q391H; 2:238262325-238262325	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2961G>A; p.S987S; 2:238253062-238253062	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.638C>T; p.S213F; 2:238271446-238271446	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2522G>A; p.C841Y; 2:238253501-238253501	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2115G>A; p.A705A; 2:238255862-238255862	prostate	carcinoma	Substitution - coding silent
c.80C>A; p.P27Q; 2:238277857-238277857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2951G>A; p.R984H; 2:238253072-238253072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.122A>G; p.H41R; 2:238277815-238277815	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.105C>T; p.S35S; 2:238277832-238277832	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2935C>A; p.P979T; 2:238253088-238253088	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2849C>T; p.P950L; 2:238253174-238253174	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3382A>G; p.I1128V; 2:238250636-238250636	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1611G>T; p.K537N; 2:238259985-238259985	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1844C>T; p.A615V; 2:238258332-238258332	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1429A>T; p.S477C; 2:238260941-238260941	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2327C>A; p.P776H; 2:238253696-238253696	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1425C>T; p.P475P; 2:238260945-238260945	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.668G>A; p.S223N; 2:238271416-238271416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1562A>G; p.N521S; 2:238260034-238260034	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2826C>A; p.A942A; 2:238253197-238253197	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1562A>G; p.N521S; 2:238260034-238260034	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3648delA; p.G1217fs*31; 2:238246495-238246495	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.932T>C; p.L311P; 2:238268091-238268091	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.61C>A; p.P21T; 2:238277876-238277876	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2469G>A; p.L823L; 2:238253554-238253554	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2469G>A; p.L823L; 2:238253554-238253554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2469G>A; p.L823L; 2:238253554-238253554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1102G>A; p.V368M; 2:238263003-238263003	breast	carcinoma	Substitution - Missense
c.3765G>A; p.T1255T; 2:238246378-238246378	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3670G>A; p.E1224K; 2:238246473-238246473	breast	carcinoma	Substitution - Missense
c.2317C>T; p.R773*; 2:238255660-238255660	breast	carcinoma	Substitution - Nonsense
c.1946C>G; p.T649R; 2:238257041-238257041	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.548C>T; p.S183F; 2:238273092-238273092	skin	malignant_melanoma	Substitution - Missense
c.891G>A; p.K297K; 2:238268132-238268132	skin	malignant_melanoma	Substitution - coding silent
c.2806A>G; p.T936A; 2:238253217-238253217	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.505G>C; p.D169H; 2:238273135-238273135	breast	carcinoma	Substitution - Missense
c.2964C>T; p.P988P; 2:238253059-238253059	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3108G>C; p.L1036L; 2:238252915-238252915	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.535G>A; p.E179K; 2:238273105-238273105	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1541C>T; p.A514V; 2:238260829-238260829	skin	malignant_melanoma	Substitution - Missense
c.2327C>T; p.P776L; 2:238253696-238253696	skin	malignant_melanoma	Substitution - Missense
c.3187G>T; p.E1063*; 2:238251686-238251686	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3408C>A; p.I1136I; 2:238250610-238250610	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2638G>A; p.A880T; 2:238253385-238253385	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3537C>G; p.F1179L; 2:238249143-238249143	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.817C>T; p.R273C; 2:238268930-238268930	bone; pelvis	chondrosarcoma	Substitution - Missense
c.582G>A; p.A194A; 2:238271502-238271502	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1519G>A; p.E507K; 2:238260851-238260851	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3237C>T; p.S1079S; 2:238251636-238251636	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.703G>A; p.D235N; 2:238271381-238271381	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2028C>T; p.I676I; 2:238256959-238256959	skin	malignant_melanoma	Substitution - coding silent
c.3272C>T; p.A1091V; 2:238251601-238251601	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2346C>T; p.S782S; 2:238253677-238253677	breast	carcinoma	Substitution - coding silent
c.306T>G; p.S102S; 2:238275885-238275885	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1201C>T; p.R401C; 2:238262297-238262297	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1821C>T; p.C607C; 2:238258355-238258355	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1306G>A; p.V436M; 2:238262192-238262192	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3264G>A; p.P1088P; 2:238251609-238251609	NS	NS	Substitution - coding silent
c.3452A>G; p.Y1151C; 2:238250566-238250566	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3046G>A; p.A1016T; 2:238252977-238252977	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2320+6T>C; p.?; 2:238255651-238255651	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Unknown
c.84G>A; p.L28L; 2:238277853-238277853	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2100C>T; p.S700S; 2:238255877-238255877	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2866C>T; p.P956S; 2:238253157-238253157	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.12C>T; p.Y4Y; 2:238277925-238277925	liver	carcinoma	Substitution - coding silent
c.2688C>T; p.F896F; 2:238253335-238253335	skin	malignant_melanoma	Substitution - coding silent
c.3204C>T; p.A1068A; 2:238251669-238251669	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2741C>T; p.P914L; 2:238253282-238253282	skin	malignant_melanoma	Substitution - Missense
c.1256A>G; p.N419S; 2:238262242-238262242	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3681T>A; p.I1227I; 2:238246462-238246462	skin	malignant_melanoma	Substitution - coding silent
c.2307G>A; p.Q769Q; 2:238255670-238255670	skin	malignant_melanoma	Substitution - coding silent
c.1075C>T; p.Q359*; 2:238263030-238263030	skin	malignant_melanoma	Substitution - Nonsense
c.746C>T; p.P249L; 2:238271338-238271338	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2735C>T; p.S912F; 2:238253288-238253288	skin	malignant_melanoma	Substitution - Missense
c.746C>T; p.P249L; 2:238271338-238271338	skin	malignant_melanoma	Substitution - Missense
c.2748G>A; p.G916G; 2:238253275-238253275	skin	malignant_melanoma	Substitution - coding silent
c.2735C>T; p.S912F; 2:238253288-238253288	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.328G>A; p.E110K; 2:238275863-238275863	skin	malignant_melanoma	Substitution - Missense
c.2852G>A; p.S951N; 2:238253171-238253171	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3306T>A; p.Y1102*; 2:238250712-238250712	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.426C>T; p.L142L; 2:238275765-238275765	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3093G>A; p.Q1031Q; 2:238252930-238252930	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.116G>A; p.S39N; 2:238277821-238277821	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.116G>A; p.S39N; 2:238277821-238277821	large_intestine; colon	carcinoma	Substitution - Missense
c.248T>C; p.L83P; 2:238277176-238277176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1627+1G>T; p.?; 2:238259968-238259968	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Unknown
c.2644C>T; p.P882S; 2:238253379-238253379	liver	carcinoma	Substitution - Missense
c.2644C>T; p.P882S; 2:238253379-238253379	liver	carcinoma	Substitution - Missense
c.2448C>T; p.P816P; 2:238253575-238253575	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.214_215CC>TT; p.P72L; 2:238277722-238277723	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.801G>T; p.E267D; 2:238268946-238268946	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.152G>C; p.R51P; 2:238277785-238277785	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1935G>T; p.T645T; 2:238257052-238257052	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.151C>T; p.R51W; 2:238277786-238277786	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2413C>T; p.R805*; 2:238253610-238253610	skin	malignant_melanoma	Substitution - Nonsense
c.3275-1G>T; p.?; 2:238250744-238250744	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1501A>T; p.S501C; 2:238260869-238260869	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3357T>A; p.T1119T; 2:238250661-238250661	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2914G>T; p.A972S; 2:238253109-238253109	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1494C>T; p.T498T; 2:238260876-238260876	skin	malignant_melanoma	Substitution - coding silent
c.2740C>T; p.P914S; 2:238253283-238253283	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.216G>A; p.P72P; 2:238277721-238277721	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.2278T>C; p.Y760H; 2:238255699-238255699	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.178G>A; p.D60N; 2:238277759-238277759	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.354G>A; p.L118L; 2:238275837-238275837	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2689C>T; p.P897S; 2:238253334-238253334	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2998C>T; p.P1000S; 2:238253025-238253025	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1958C>T; p.S653L; 2:238257029-238257029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1934C>T; p.T645M; 2:238257053-238257053	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1768G>A; p.V590I; 2:238258504-238258504	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1768G>A; p.V590I; 2:238258504-238258504	stomach	adenocarcinoma	Substitution - Missense
c.1447G>A; p.G483R; 2:238260923-238260923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3140G>C; p.S1047T; 2:238251733-238251733	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.3496A>G; p.R1166G; 2:238249184-238249184	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.3592_3593GG>TT; p.G1198F; 2:238249087-238249088	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3144C>T; p.D1048D; 2:238251729-238251729	stomach	adenocarcinoma	Substitution - coding silent
c.570+1G>A; p.?; 2:238273069-238273069	breast	carcinoma	Unknown
c.3496A>G; p.R1166G; 2:238249184-238249184	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3140G>C; p.S1047T; 2:238251733-238251733	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2818G>C; p.E940Q; 2:238253205-238253205	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.215C>T; p.P72L; 2:238277722-238277722	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1168G>A; p.G390R; 2:238262330-238262330	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1972G>A; p.G658S; 2:238257015-238257015	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.776C>A; p.S259Y; 2:238268971-238268971	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1658A>G; p.K553R; 2:238258614-238258614	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.177C>T; p.D59D; 2:238277760-238277760	stomach	adenocarcinoma	Substitution - coding silent
c.1705G>A; p.E569K; 2:238258567-238258567	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3163G>A; p.G1055S; 2:238251710-238251710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1254C>T; p.I418I; 2:238262244-238262244	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2612C>T; p.P871L; 2:238253411-238253411	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2831C>T; p.A944V; 2:238253192-238253192	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]