Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

89870

Name

TRIM15

Synonymous

tripartite motif containing 15;TRIM15;tripartite motif containing 15

Definition

RING finger protein 93|tripartite motif-containing 15|tripartite motif-containing protein 15|zinc finger protein 178|zinc finger protein B7

Position

6p21.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

Top

There is no record for TRIM15

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.135G>C; p.Q45H; 6:30163819-30163819

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.221C>T; p.P74L; 6:30163905-30163905

 skinmalignant_melanomaSubstitution - Missense

c.791T>C; p.I264T; 6:30170560-30170560

 central_nervous_system; braingliomaSubstitution - Missense

c.4C>T; p.P2S; 6:30163688-30163688

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1263C>T; p.Y421Y; 6:30172214-30172214

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.270C>T; p.I90I; 6:30163954-30163954

 breastcarcinomaSubstitution - coding silent

c.1037C>G; p.S346C; 6:30171988-30171988

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.971G>A; p.S324N; 6:30171922-30171922

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.463C>T; p.L155F; 6:30167257-30167257

 skinmalignant_melanomaSubstitution - Missense

c.856G>C; p.A286P; 6:30170984-30170984

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.859C>A; p.H287N; 6:30170987-30170987

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.777C>T; p.D259D; 6:30170546-30170546

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.234G>T; p.L78L; 6:30163918-30163918

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.273_275delCTT; p.F93delF; 6:30163957-30163959

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.128T>G; p.L43R; 6:30163812-30163812

 livercarcinomaSubstitution - Missense

c.128T>G; p.L43R; 6:30163812-30163812

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.233T>C; p.L78P; 6:30163917-30163917

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.907G>A; p.A303T; 6:30171858-30171858

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.535G>A; p.E179K; 6:30168357-30168357

 skinmalignant_melanomaSubstitution - Missense

c.576G>A; p.R192R; 6:30168398-30168398

 skinmalignant_melanomaSubstitution - coding silent

c.1335C>T; p.S445S; 6:30172286-30172286

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.138G>A; p.M46I; 6:30163822-30163822

 skinmalignant_melanomaSubstitution - Missense

c.410T>C; p.L137P; 6:30167204-30167204

 central_nervous_system; braingliomaSubstitution - Missense

c.451G>A; p.E151K; 6:30167245-30167245

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1360G>A; p.V454I; 6:30172311-30172311

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.663G>A; p.K221K; 6:30168485-30168485

 skinmalignant_melanomaSubstitution - coding silent

c.749T>C; p.F250S; 6:30170518-30170518

 central_nervous_system; braingliomaSubstitution - Missense

c.420G>A; p.E140E; 6:30167214-30167214

 pancreascarcinomaSubstitution - coding silent

c.415A>C; p.T139P; 6:30167209-30167209

 skinmalignant_melanomaSubstitution - Missense

c.436G>A; p.D146N; 6:30167230-30167230

 skinmalignant_melanomaSubstitution - Missense

c.770C>A; p.S257Y; 6:30170539-30170539

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.436G>A; p.D146N; 6:30167230-30167230

 skinmalignant_melanomaSubstitution - Missense

c.437delA; p.D146fs*2; 6:30167231-30167231

 livercarcinomaDeletion - Frameshift

c.709G>A; p.D237N; 6:30169241-30169241

 skinmalignant_melanomaSubstitution - Missense

c.621A>T; p.T207T; 6:30168443-30168443

 livercarcinomaSubstitution - coding silent

c.913C>T; p.R305W; 6:30171864-30171864

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.294C>A; p.A98A; 6:30163978-30163978

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.263_265delAGA; p.K89delK; 6:30163947-30163949

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - In frame

c.118C>T; p.L40F; 6:30163802-30163802

 pleurapulmonary_blastomaSubstitution - Missense

c.385C>T; p.R129C; 6:30167179-30167179

 skinmalignant_melanomaSubstitution - Missense

c.385C>T; p.R129C; 6:30167179-30167179

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1389G>A; p.L463L; 6:30172340-30172340

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.562C>T; p.L188L; 6:30168384-30168384

 skinmalignant_melanomaSubstitution - coding silent

c.84C>A; p.T28T; 6:30163768-30163768

 kidneyother; neoplasmSubstitution - coding silent

c.571C>T; p.L191L; 6:30168393-30168393

 skinmalignant_melanomaSubstitution - coding silent

c.843C>T; p.F281F; 6:30170612-30170612

 skinmalignant_melanomaSubstitution - coding silent

c.1336G>T; p.G446C; 6:30172287-30172287

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.393G>A; p.R131R; 6:30167187-30167187

 skinmalignant_melanomaSubstitution - coding silent

c.1044C>A; p.R348R; 6:30171995-30171995

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1156G>A; p.V386I; 6:30172107-30172107

 pancreascarcinomaSubstitution - Missense

c.120C>T; p.L40L; 6:30163804-30163804

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1026G>A; p.P342P; 6:30171977-30171977

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.371A>C; p.Q124P; 6:30164055-30164055

 prostatecarcinomaSubstitution - Missense

c.1278G>A; p.V426V; 6:30172229-30172229

 skinmalignant_melanomaSubstitution - coding silent

c.1253C>T; p.A418V; 6:30172204-30172204

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.478-1G>A; p.?; 6:30168299-30168299

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourUnknown

c.149C>T; p.S50F; 6:30163833-30163833

 skinmalignant_melanomaSubstitution - Missense

c.149C>T; p.S50F; 6:30163833-30163833

 NSmalignant_melanomaSubstitution - Missense

c.1079G>A; p.G360D; 6:30172030-30172030

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.187G>A; p.E63K; 6:30163871-30163871

 skinmalignant_melanomaSubstitution - Missense

c.289G>T; p.D97Y; 6:30163973-30163973

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.854T>C; p.L285S; 6:30170982-30170982

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1202C>A; p.S401Y; 6:30172153-30172153

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.370C>T; p.Q124*; 6:30164054-30164054

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.486C>T; p.I162I; 6:30168308-30168308

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1360G>C; p.V454L; 6:30172311-30172311

 pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Substitution - Missense

c.1360G>C; p.V454L; 6:30172311-30172311

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.1213G>A; p.D405N; 6:30172164-30172164

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.141G>T; p.G47G; 6:30163825-30163825

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.751G>A; p.V251M; 6:30170520-30170520

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.487G>A; p.E163K; 6:30168309-30168309

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.301C>T; p.L101F; 6:30163985-30163985

 skinmalignant_melanomaSubstitution - Missense

c.605G>T; p.R202M; 6:30168427-30168427

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.355C>T; p.L119L; 6:30164039-30164039

 skinmalignant_melanomaSubstitution - coding silent

c.785A>G; p.K262R; 6:30170554-30170554

 skin; trunkmalignant_melanomaSubstitution - Missense

c.106T>C; p.C36R; 6:30163790-30163790

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.934G>A; p.D312N; 6:30171885-30171885

 skinmalignant_melanomaSubstitution - Missense

c.793C>T; p.R265C; 6:30170562-30170562

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.541G>T; p.E181*; 6:30168363-30168363

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.259G>A; p.G87S; 6:30163943-30163943

 central_nervous_system; braingliomaSubstitution - Missense

c.288C>T; p.N96N; 6:30163972-30163972

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.345C>A; p.T115T; 6:30164029-30164029

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.85A>G; p.I29V; 6:30163769-30163769

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.805A>C; p.R269R; 6:30170574-30170574

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.859C>T; p.H287Y; 6:30170987-30170987

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.85A>G; p.I29V; 6:30163769-30163769

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.85A>G; p.I29V; 6:30163769-30163769

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.229C>T; p.P77S; 6:30163913-30163913

 skinmalignant_melanomaSubstitution - Missense

c.722A>G; p.N241S; 6:30169254-30169254

 skinmalignant_melanomaSubstitution - Missense

c.289G>A; p.D97N; 6:30163973-30163973

 prostatecarcinomaSubstitution - Missense

c.1337G>A; p.G446D; 6:30172288-30172288

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.112C>T; p.L38F; 6:30163796-30163796

 skinmalignant_melanomaSubstitution - Missense

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