| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 89884 |
Name | LHX4 |
Synonymous | LIM homeobox 4;LHX4;LIM homeobox 4 |
Definition | LIM homeobox protein 4|LIM/homeobox protein Lhx4 |
Position | 1q25.2 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.03. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.898C>G; p.Q300E; 1:180274304-180274304 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.775C>T; p.R259*; 1:180272003-180272003 |
stomach | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1147G>A; p.D383N; 1:180274553-180274553 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.452-5T>C; p.?; 1:180271375-180271375 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Unknown |
c.641G>A; p.R214H; 1:180271869-180271869 |
breast | carcinoma | Substitution - Missense |
c.607-2A>G; p.?; 1:180271833-180271833 |
kidney | other; neoplasm | Unknown |
c.1012T>G; p.L338V; 1:180274418-180274418 |
skin | malignant_melanoma | Substitution - Missense |
c.669C>T; p.R223R; 1:180271897-180271897 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.293C>A; p.P98Q; 1:180266436-180266436 |
autonomic_ganglia | neuroblastoma | Substitution - Missense |
c.272C>A; p.A91D; 1:180266415-180266415 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.272C>A; p.A91D; 1:180266415-180266415 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.776G>A; p.R259Q; 1:180272004-180272004 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.919C>A; p.P307T; 1:180274325-180274325 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.251G>A; p.R84H; 1:180266394-180266394 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.846C>T; p.G282G; 1:180274252-180274252 |
breast | carcinoma | Substitution - coding silent |
c.964T>C; p.S322P; 1:180274370-180274370 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.704G>A; p.R235Q; 1:180271932-180271932 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.519G>T; p.K173N; 1:180271447-180271447 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.194C>T; p.A65V; 1:180248402-180248402 |
pancreas | carcinoma | Substitution - Missense |
c.1077C>T; p.P359P; 1:180274483-180274483 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.983A>G; p.N328S; 1:180274389-180274389 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.983A>G; p.N328S; 1:180274389-180274389 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.983A>G; p.N328S; 1:180274389-180274389 |
thyroid | other; neoplasm | Substitution - Missense |
c.377C>T; p.T126M; 1:180266520-180266520 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.365G>A; p.R122Q; 1:180266508-180266508 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.161G>A; p.C54Y; 1:180248369-180248369 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.167A>C; p.K56T; 1:180248375-180248375 |
breast | carcinoma | Substitution - Missense |
c.970G>A; p.A324T; 1:180274376-180274376 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.802G>A; p.G268S; 1:180274208-180274208 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.970G>A; p.A324T; 1:180274376-180274376 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.970G>A; p.A324T; 1:180274376-180274376 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.611G>A; p.W204*; 1:180271839-180271839 |
skin | malignant_melanoma | Substitution - Nonsense |
c.129G>A; p.L43L; 1:180248337-180248337 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.734C>T; p.S245F; 1:180271962-180271962 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.509A>G; p.E170G; 1:180271437-180271437 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.385G>A; p.E129K; 1:180266528-180266528 |
skin | malignant_melanoma | Substitution - Missense |
c.385G>A; p.E129K; 1:180266528-180266528 |
skin | malignant_melanoma | Substitution - Missense |
c.281A>T; p.Q94L; 1:180266424-180266424 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.258C>A; p.G86G; 1:180266401-180266401 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.258C>T; p.G86G; 1:180266401-180266401 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.298C>A; p.Q100K; 1:180266441-180266441 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.1090T>C; p.S364P; 1:180274496-180274496 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.829G>A; p.V277M; 1:180274235-180274235 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Missense |
c.829G>A; p.V277M; 1:180274235-180274235 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.71T>G; p.M24R; 1:180230600-180230600 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1020C>A; p.I340I; 1:180274426-180274426 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.771C>T; p.S257S; 1:180271999-180271999 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1025C>G; p.A342G; 1:180274431-180274431 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.734C>G; p.S245C; 1:180271962-180271962 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.551G>C; p.R184P; 1:180271479-180271479 |
pancreas | carcinoma | Substitution - Missense |
c.828C>T; p.N276N; 1:180274234-180274234 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.828C>T; p.N276N; 1:180274234-180274234 |
prostate | carcinoma | Substitution - coding silent |
c.1039G>A; p.G347R; 1:180274445-180274445 |
skin | malignant_melanoma | Substitution - Missense |
c.569T>C; p.L190P; 1:180271497-180271497 |
kidney | other; neoplasm | Substitution - Missense |
c.218G>A; p.G73E; 1:180248426-180248426 |
skin | malignant_melanoma | Substitution - Missense |
c.777A>T; p.R259R; 1:180272005-180272005 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.1117G>A; p.D373N; 1:180274523-180274523 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.667C>T; p.R223C; 1:180271895-180271895 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.722_724delAGA; p.K242delK; 1:180271950-180271952 |
lung | carcinoma; small_cell_carcinoma | Deletion - In frame |
c.81T>C; p.I27I; 1:180248289-180248289 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.804C>T; p.G268G; 1:180274210-180274210 |
skin | malignant_melanoma | Substitution - coding silent |
c.245T>C; p.F82S; 1:180248453-180248453 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.636G>T; p.E212D; 1:180271864-180271864 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.342C>A; p.C114*; 1:180266485-180266485 |
stomach | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.913G>A; p.G305R; 1:180274319-180274319 |
skin; extremity | malignant_melanoma | Substitution - Missense |
c.243C>T; p.F81F; 1:180248451-180248451 |
skin | malignant_melanoma | Substitution - coding silent |
c.400G>A; p.E134K; 1:180266543-180266543 |
oesophagus; upper_third | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.825C>T; p.G275G; 1:180274231-180274231 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.430T>C; p.Y144H; 1:180266573-180266573 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.945C>T; p.S315S; 1:180274351-180274351 |
skin | malignant_melanoma | Substitution - coding silent |
c.1040G>A; p.G347E; 1:180274446-180274446 |
skin | malignant_melanoma | Substitution - Missense |
c.1040G>A; p.G347E; 1:180274446-180274446 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.903C>T; p.D301D; 1:180274309-180274309 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.672G>C; p.W224C; 1:180271900-180271900 |
skin | malignant_melanoma | Substitution - Missense |
c.877G>A; p.D293N; 1:180274283-180274283 |
skin | malignant_melanoma | Substitution - Missense |
c.814A>G; p.R272G; 1:180274220-180274220 |
breast | carcinoma | Substitution - Missense |
c.359G>A; p.C120Y; 1:180266502-180266502 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.249G>A; p.K83K; 1:180266392-180266392 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.876G>A; p.M292I; 1:180274282-180274282 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.482G>A; p.R161Q; 1:180271410-180271410 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.779-1G>A; p.?; 1:180274184-180274184 |
lung | carcinoma; adenocarcinoma | Unknown |
c.949A>G; p.I317V; 1:180274355-180274355 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.880G>A; p.G294R; 1:180274286-180274286 |
skin | malignant_melanoma | Substitution - Missense |
c.880G>A; p.G294R; 1:180274286-180274286 |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma | Substitution - Missense |
c.1053G>A; p.T351T; 1:180274459-180274459 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |