Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

8991

Name

SELENBP1

Synonymous

selenium binding protein 1;SELENBP1;selenium binding protein 1

Definition

56 kDa selenium-binding protein|epididymis secretory sperm binding protein Li 134P|selenium-binding protein 1

Position

1q21.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.06.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1058G>A; p.G353D; 1:151365268-151365268

 oesophagus; upper_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1146G>A; p.R382R; 1:151365036-151365036

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.555G>A; p.P185P; 1:151366831-151366831

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.192C>T; p.P64P; 1:151369172-151369172

 skinmalignant_melanomaSubstitution - coding silent

c.1317C>G; p.N439K; 1:151364645-151364645

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.584G>A; p.R195Q; 1:151366802-151366802

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.584G>A; p.R195Q; 1:151366802-151366802

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.584G>A; p.R195Q; 1:151366802-151366802

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1362C>T; p.A454A; 1:151364600-151364600

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.340C>T; p.R114W; 1:151369024-151369024

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1357C>T; p.P453S; 1:151364605-151364605

 skinmalignant_melanomaSubstitution - Missense

c.6T>G; p.A2A; 1:151369768-151369768

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.715G>T; p.V239L; 1:151366403-151366403

 breastcarcinomaSubstitution - Missense

c.1341G>A; p.G447G; 1:151364621-151364621

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.381C>T; p.I127I; 1:151368299-151368299

 skinmalignant_melanomaSubstitution - coding silent

c.748C>T; p.P250S; 1:151366370-151366370

 skinmalignant_melanomaSubstitution - Missense

c.748C>T; p.P250S; 1:151366370-151366370

 skinmalignant_melanomaSubstitution - Missense

c.1255A>G; p.R419G; 1:151364927-151364927

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.879G>A; p.V293V; 1:151365811-151365811

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.131T>A; p.L44Q; 1:151369485-151369485

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1387G>A; p.G463R; 1:151364575-151364575

 NSmalignant_melanomaSubstitution - Missense

c.1387G>A; p.G463R; 1:151364575-151364575

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.1387G>A; p.G463R; 1:151364575-151364575

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.882C>T; p.P294P; 1:151365808-151365808

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1374G>A; p.E458E; 1:151364588-151364588

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.410A>C; p.H137P; 1:151368270-151368270

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.1145G>A; p.R382Q; 1:151365037-151365037

 skinmalignant_melanomaSubstitution - Missense

c.1249C>G; p.L417V; 1:151364933-151364933

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.696C>T; p.D232D; 1:151366422-151366422

 central_nervous_system; braingliomaSubstitution - coding silent

c.1144C>T; p.R382W; 1:151365038-151365038

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.297C>A; p.L99L; 1:151369067-151369067

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.184C>T; p.R62W; 1:151369180-151369180

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1173G>C; p.Q391H; 1:151365009-151365009

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.453C>T; p.S151S; 1:151368227-151368227

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.704G>A; p.R235H; 1:151366414-151366414

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1165A>G; p.M389V; 1:151365017-151365017

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.157T>C; p.S53P; 1:151369459-151369459

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.870G>A; p.V290V; 1:151365820-151365820

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1032C>T; p.R344R; 1:151365575-151365575

 skinmalignant_melanomaSubstitution - coding silent

c.1099G>A; p.E367K; 1:151365227-151365227

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.1110G>C; p.K370N; 1:151365216-151365216

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.710A>G; p.E237G; 1:151366408-151366408

 skinmalignant_melanomaSubstitution - Missense

c.642C>T; p.F214F; 1:151366744-151366744

 skinmalignant_melanomaSubstitution - coding silent

c.642C>T; p.F214F; 1:151366744-151366744

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.552A>G; p.A184A; 1:151366834-151366834

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.933C>T; p.T311T; 1:151365674-151365674

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.761G>A; p.R254H; 1:151366357-151366357

 livercarcinomaSubstitution - Missense

c.779A>T; p.D260V; 1:151366339-151366339

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.761G>A; p.R254H; 1:151366357-151366357

 livercarcinomaSubstitution - Missense

c.1031G>A; p.R344H; 1:151365576-151365576

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.899G>A; p.G300D; 1:151365791-151365791

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.827G>T; p.R276L; 1:151366291-151366291

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.954C>T; p.D318D; 1:151365653-151365653

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1258G>A; p.E420K; 1:151364704-151364704

 skinmalignant_melanomaSubstitution - Missense

c.110G>A; p.G37D; 1:151369506-151369506

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.910C>G; p.P304A; 1:151365780-151365780

 central_nervous_system; braingliomaSubstitution - Missense

c.1408A>C; p.I470L; 1:151364554-151364554

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1232A>C; p.K411T; 1:151364950-151364950

 kidneyother; neoplasmSubstitution - Missense

c.252C>T; p.F84F; 1:151369112-151369112

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.9G>A; p.T3T; 1:151369765-151369765

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.412A>C; p.T138P; 1:151368268-151368268

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.412A>C; p.T138P; 1:151368268-151368268

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.884C>T; p.P295L; 1:151365806-151365806

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.688G>A; p.V230I; 1:151366430-151366430

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1193G>A; p.R398H; 1:151364989-151364989

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1193G>A; p.R398H; 1:151364989-151364989

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.913G>A; p.E305K; 1:151365777-151365777

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1193G>A; p.R398H; 1:151364989-151364989

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1193G>A; p.R398H; 1:151364989-151364989

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.433G>T; p.G145W; 1:151368247-151368247

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1061G>T; p.S354I; 1:151365265-151365265

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.588C>T; p.H196H; 1:151366798-151366798

 stomachadenocarcinomaSubstitution - coding silent

c.1332G>A; p.V444V; 1:151364630-151364630

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.990G>T; p.G330G; 1:151365617-151365617

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.486T>G; p.G162G; 1:151366900-151366900

 pancreascarcinomaSubstitution - coding silent

c.302C>T; p.S101F; 1:151369062-151369062

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1303G>T; p.G435W; 1:151364659-151364659

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.805G>A; p.A269T; 1:151366313-151366313

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.805G>A; p.A269T; 1:151366313-151366313

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1265C>T; p.S422F; 1:151364697-151364697

 skinmalignant_melanomaSubstitution - Missense

c.1317_1318insGTTGAAC; p.P440fs*21; 1:151364644-151364645

 lungcarcinoma; adenocarcinomaInsertion - Frameshift

c.341G>T; p.R114L; 1:151369023-151369023

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.482G>C; p.G161A; 1:151366904-151366904

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.30C>G; p.P10P; 1:151369744-151369744

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1093G>T; p.E365*; 1:151365233-151365233

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1407C>A; p.D469E; 1:151364555-151364555

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.760C>T; p.R254C; 1:151366358-151366358

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.614C>A; p.A205E; 1:151366772-151366772

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.220C>G; p.H74D; 1:151369144-151369144

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.742C>T; p.L248F; 1:151366376-151366376

 skinmalignant_melanomaSubstitution - Missense

c.827G>A; p.R276H; 1:151366291-151366291

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.5-4A>T; p.?; 1:151369773-151369773

 thyroidother; neoplasmUnknown

c.338C>T; p.P113L; 1:151369026-151369026

 skinmalignant_melanomaSubstitution - Missense

c.1338C>T; p.F446F; 1:151364624-151364624

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

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