Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

92335

Name

STRADA

Synonymous

STE20-related kinase adaptor alpha;STRADA;STE20-related kinase adaptor alpha

Definition

STE20-like pseudokinase|STE20-related kinase adapter protein alpha|STRAD alpha|protein kinase LYK5|serologically defined breast cancer antigen NY-BR-96

Position

17q23.3

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.15.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.130G>C; p.D44H; 17:63714102-63714102

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.926A>G; p.E309G; 17:63704515-63704515

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.609C>A; p.I203I; 17:63707391-63707391

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.474C>T; p.L158L; 17:63710598-63710598

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1281C>T; p.D427D; 17:63703614-63703614

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.37C>T; p.R13W; 17:63726695-63726695

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.37C>T; p.R13W; 17:63726695-63726695

 stomachadenocarcinomaSubstitution - Missense

c.811G>A; p.E271K; 17:63706682-63706682

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.469G>C; p.D157H; 17:63710603-63710603

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.169G>C; p.E57Q; 17:63714063-63714063

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1026C>T; p.H342H; 17:63704415-63704415

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.997delC; p.R333fs*42; 17:63704444-63704444

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.997delC; p.R333fs*42; 17:63704444-63704444

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.997delC; p.R333fs*42; 17:63704444-63704444

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.997delC; p.R333fs*42; 17:63704444-63704444

 pancreascarcinoma; acinar_carcinomaDeletion - Frameshift

c.997delC; p.R333fs*42; 17:63704444-63704444

 stomachcarcinoma; intestinal_adenocarcinomaDeletion - Frameshift

c.997delC; p.R333fs*42; 17:63704444-63704444

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.997delC; p.R333fs*42; 17:63704444-63704444

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.997delC; p.R333fs*42; 17:63704444-63704444

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.883A>T; p.T295S; 17:63704558-63704558

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1261C>A; p.L421M; 17:63703634-63703634

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.135G>A; p.A45A; 17:63714097-63714097

 bone; fibulaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.497G>A; p.G166D; 17:63710575-63710575

 breastcarcinomaSubstitution - Missense

c.691C>G; p.H231D; 17:63707309-63707309

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.401G>T; p.R134L; 17:63710784-63710784

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.47C>T; p.S16L; 17:63726685-63726685

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.57C>A; p.F19L; 17:63726675-63726675

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.416C>T; p.A139V; 17:63710769-63710769

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1084C>T; p.R362C; 17:63704357-63704357

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.725C>T; p.P242L; 17:63707275-63707275

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.879C>T; p.N293N; 17:63704562-63704562

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.879C>T; p.N293N; 17:63704562-63704562

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.879C>T; p.N293N; 17:63704562-63704562

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.676C>G; p.R226G; 17:63707324-63707324

 breastcarcinomaSubstitution - Missense

c.1238G>A; p.G413E; 17:63703657-63703657

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.48G>A; p.S16S; 17:63726684-63726684

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1226A>G; p.Q409R; 17:63703669-63703669

 prostatecarcinomaSubstitution - Missense

c.1226A>G; p.Q409R; 17:63703669-63703669

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.992C>T; p.T331I; 17:63704449-63704449

 pancreascarcinoid-endocrine_tumourSubstitution - Missense

c.1242C>A; p.I414I; 17:63703653-63703653

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.134C>T; p.A45V; 17:63714098-63714098

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.352G>A; p.E118K; 17:63710833-63710833

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.352G>A; p.E118K; 17:63710833-63710833

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.797G>C; p.G266A; 17:63706696-63706696

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.230A>G; p.K77R; 17:63713524-63713524

 large_intestine; colonNSSubstitution - Missense

c.1217_1218GC>TA; p.S406I; 17:63703677-63703678

 prostatecarcinomaSubstitution - Missense

c.390C>T; p.I130I; 17:63710795-63710795

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.940C>T; p.P314S; 17:63704501-63704501

 skinmalignant_melanomaSubstitution - Missense

c.1082A>G; p.Q361R; 17:63704359-63704359

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.944C>T; p.S315L; 17:63704497-63704497

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.525C>T; p.I175I; 17:63710547-63710547

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1194C>A; p.T398T; 17:63703701-63703701

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.195G>T; p.E65D; 17:63714037-63714037

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.123+2T>C; p.?; 17:63723296-63723296

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.78T>G; p.D26E; 17:63726654-63726654

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.388A>G; p.I130V; 17:63710797-63710797

 breastcarcinomaSubstitution - Missense

c.1122G>T; p.L374L; 17:63704026-63704026

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.382C>A; p.P128T; 17:63710803-63710803

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

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