Entrez Gene

Basic Information
Gene ID	9462
Name	RASAL2
Synonymous	RAS protein activator like 2;RASAL2;RAS protein activator like 2
Definition	RAS protein activator-like 2\|Ras protein activator like 1\|ras GTPase-activating protein nGAP
Position	1q24
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.17.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.954C>A; p.F318L; 1:178442755-178442755	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2685C>T; p.P895P; 1:178458010-178458010	skin	malignant_melanoma	Substitution - coding silent
c.2147A>T; p.Q716L; 1:178454638-178454638	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1843G>A; p.A615T; 1:178452540-178452540	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1249A>G; p.K417E; 1:178443050-178443050	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.3044C>T; p.P1015L; 1:178458369-178458369	skin	malignant_melanoma	Substitution - Missense
c.1527G>T; p.E509D; 1:178445616-178445616	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3637G>A; p.D1213N; 1:178467413-178467413	skin	malignant_melanoma	Substitution - Missense
c.1055C>T; p.P352L; 1:178442856-178442856	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1578G>C; p.E526D; 1:178451575-178451575	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2856G>A; p.K952K; 1:178458181-178458181	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2627T>C; p.I876T; 1:178457952-178457952	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1555T>A; p.Y519N; 1:178445644-178445644	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2434C>G; p.Q812E; 1:178457759-178457759	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1659T>C; p.H553H; 1:178451656-178451656	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.22G>A; p.D8N; 1:178094568-178094568	urinary_tract; bladder	carcinoma	Substitution - Missense
c.358G>T; p.E120*; 1:178300073-178300073	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.957C>T; p.C319C; 1:178442758-178442758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.957C>T; p.C319C; 1:178442758-178442758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3245C>T; p.T1082I; 1:178464303-178464303	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.936C>T; p.A312A; 1:178442737-178442737	skin	malignant_melanoma	Substitution - coding silent
c.1907C>T; p.T636I; 1:178452604-178452604	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1907C>T; p.T636I; 1:178452604-178452604	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1219G>A; p.G407R; 1:178443020-178443020	skin	malignant_melanoma	Substitution - Missense
c.604C>T; p.R202C; 1:178420604-178420604	skin	malignant_melanoma	Substitution - Missense
c.3771C>T; p.S1257S; 1:178473200-178473200	skin	malignant_melanoma	Substitution - coding silent
c.1030G>A; p.E344K; 1:178442831-178442831	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2637G>A; p.L879L; 1:178457962-178457962	liver	carcinoma	Substitution - coding silent
c.2169C>A; p.S723S; 1:178456711-178456711	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.601C>T; p.L201F; 1:178420601-178420601	skin	malignant_melanoma	Substitution - Missense
c.1718+1G>A; p.?; 1:178451716-178451716	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1030G>A; p.E344K; 1:178442831-178442831	skin	malignant_melanoma	Substitution - Missense
c.954C>G; p.F318L; 1:178442755-178442755	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1305A>C; p.A435A; 1:178443106-178443106	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1527G>C; p.E509D; 1:178445616-178445616	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1758G>A; p.W586*; 1:178452455-178452455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1297G>T; p.E433*; 1:178443098-178443098	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2766T>C; p.I922I; 1:178458091-178458091	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2803G>A; p.E935K; 1:178458128-178458128	breast	carcinoma	Substitution - Missense
c.1793T>G; p.I598S; 1:178452490-178452490	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.850C>T; p.R284C; 1:178441624-178441624	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.280C>T; p.P94S; 1:178299995-178299995	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1070T>G; p.I357S; 1:178442871-178442871	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1370A>G; p.N457S; 1:178443171-178443171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2123C>T; p.S708F; 1:178454614-178454614	skin	malignant_melanoma	Substitution - Missense
c.2705A>G; p.Q902R; 1:178458030-178458030	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3083G>T; p.G1028V; 1:178458408-178458408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.923delC; p.K309fs*69; 1:178442724-178442724	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1789G>A; p.D597N; 1:178452486-178452486	skin	malignant_melanoma	Substitution - Missense
c.2168C>T; p.S723F; 1:178456710-178456710	skin	malignant_melanoma	Substitution - Missense
c.516C>A; p.F172L; 1:178420516-178420516	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2503C>T; p.R835W; 1:178457828-178457828	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.904C>T; p.R302C; 1:178442705-178442705	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1729C>T; p.R577C; 1:178452426-178452426	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2989C>T; p.Q997*; 1:178458314-178458314	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.904C>T; p.R302C; 1:178442705-178442705	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3146G>A; p.R1049Q; 1:178458471-178458471	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.904C>T; p.R302C; 1:178442705-178442705	skin	malignant_melanoma	Substitution - Missense
c.1044C>T; p.F348F; 1:178442845-178442845	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3001C>A; p.R1001R; 1:178458326-178458326	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3086G>A; p.S1029N; 1:178458411-178458411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.333G>A; p.L111L; 1:178300048-178300048	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2080G>C; p.D694H; 1:178454571-178454571	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3236A>T; p.D1079V; 1:178464294-178464294	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.333G>A; p.L111L; 1:178300048-178300048	thyroid	carcinoma	Substitution - coding silent
c.1813G>A; p.A605T; 1:178452510-178452510	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1855C>T; p.P619S; 1:178452552-178452552	skin	malignant_melanoma	Substitution - Missense
c.1097delA; p.K368fs*10; 1:178442898-178442898	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1097delA; p.K368fs*10; 1:178442898-178442898	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1097delA; p.K368fs*10; 1:178442898-178442898	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1104_1105insA; p.D372fs*4; 1:178442905-178442906	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1111_1112insA; p.D372fs*4; 1:178442912-178442913	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.454A>T; p.T152S; 1:178390150-178390150	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1104_1105insA; p.D372fs*4; 1:178442905-178442906	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.473C>T; p.S158F; 1:178390169-178390169	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3529G>T; p.D1177Y; 1:178466094-178466094	breast	carcinoma	Substitution - Missense
c.595_596CC>TT; p.P199L; 1:178420595-178420596	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1349A>T; p.E450V; 1:178443150-178443150	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1707C>G; p.I569M; 1:178451704-178451704	lung	carcinoid-endocrine_tumour; atypical	Substitution - Missense
c.1895G>A; p.R632H; 1:178452592-178452592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1580T>G; p.F527C; 1:178451577-178451577	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3655A>G; p.I1219V; 1:178473084-178473084	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.384A>G; p.P128P; 1:178300099-178300099	liver	carcinoma	Substitution - coding silent
c.384A>G; p.P128P; 1:178300099-178300099	liver	carcinoma	Substitution - coding silent
c.1825C>T; p.L609F; 1:178452522-178452522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1699A>T; p.K567*; 1:178451696-178451696	breast	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1650G>C; p.L550L; 1:178451647-178451647	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.912G>A; p.W304*; 1:178442713-178442713	pancreas	carcinoma	Substitution - Nonsense
c.912G>A; p.W304*; 1:178442713-178442713	pancreas	carcinoid-endocrine_tumour	Substitution - Nonsense
c.3065C>T; p.A1022V; 1:178458390-178458390	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2207C>A; p.P736H; 1:178456749-178456749	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2468delA; p.K824fs*40; 1:178457793-178457793	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.958G>A; p.E320K; 1:178442759-178442759	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.886C>T; p.R296*; 1:178442687-178442687	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2927G>A; p.R976K; 1:178458252-178458252	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2729C>T; p.S910L; 1:178458054-178458054	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1827C>T; p.L609L; 1:178452524-178452524	skin	malignant_melanoma	Substitution - coding silent
c.3787G>T; p.E1263*; 1:178473216-178473216	prostate	adenoma	Substitution - Nonsense
c.2144C>T; p.S715F; 1:178454635-178454635	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1625C>T; p.P542L; 1:178451622-178451622	skin	malignant_melanoma	Substitution - Missense
c.274G>A; p.E92K; 1:178283689-178283689	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1625C>T; p.P542L; 1:178451622-178451622	skin	malignant_melanoma	Substitution - Missense
c.2291C>T; p.S764F; 1:178456833-178456833	skin	malignant_melanoma	Substitution - Missense
c.3034G>C; p.A1012P; 1:178458359-178458359	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.827G>C; p.R276T; 1:178441601-178441601	breast	carcinoma	Substitution - Missense
c.358G>A; p.E120K; 1:178300073-178300073	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3776C>T; p.T1259M; 1:178473205-178473205	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1105delA; p.K371fs*7; 1:178442906-178442906	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1105delA; p.K371fs*7; 1:178442906-178442906	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1105delA; p.K371fs*7; 1:178442906-178442906	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1105delA; p.K371fs*7; 1:178442906-178442906	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1105delA; p.K371fs*7; 1:178442906-178442906	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.2206C>T; p.P736S; 1:178456748-178456748	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2206C>T; p.P736S; 1:178456748-178456748	skin	malignant_melanoma	Substitution - Missense
c.2970A>G; p.P990P; 1:178458295-178458295	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2158-1G>T; p.?; 1:178456699-178456699	lung	carcinoma; adenocarcinoma	Unknown
c.417A>G; p.E139E; 1:178390113-178390113	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.417A>G; p.E139E; 1:178390113-178390113	pancreas	carcinoma	Substitution - coding silent
c.1576G>A; p.E526K; 1:178451573-178451573	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2212G>T; p.V738F; 1:178456754-178456754	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1166G>T; p.G389V; 1:178442967-178442967	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.238_239AC>TT; p.T80L; 1:178283653-178283654	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.549G>T; p.R183S; 1:178420549-178420549	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.307A>G; p.T103A; 1:178300022-178300022	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.220C>T; p.R74W; 1:178283635-178283635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.374A>C; p.E125A; 1:178300089-178300089	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3495C>T; p.S1165S; 1:178466060-178466060	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105_1106insA; p.D372fs*4; 1:178442906-178442907	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.2753T>C; p.L918P; 1:178458078-178458078	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2158-8C>A; p.?; 1:178456692-178456692	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Unknown
c.3726G>T; p.M1242I; 1:178473155-178473155	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.172C>T; p.R58C; 1:178283587-178283587	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3726G>T; p.M1242I; 1:178473155-178473155	stomach	adenocarcinoma	Substitution - Missense
c.625C>T; p.R209C; 1:178439426-178439426	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.3593A>G; p.H1198R; 1:178467369-178467369	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1939C>A; p.L647M; 1:178452636-178452636	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.573C>T; p.D191D; 1:178420573-178420573	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3382G>A; p.E1128K; 1:178465947-178465947	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3188T>G; p.V1063G; 1:178458513-178458513	pancreas	carcinoma	Substitution - Missense
c.230G>A; p.C77Y; 1:178283645-178283645	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3272C>T; p.A1091V; 1:178464330-178464330	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1112_1113insA; p.D372fs*4; 1:178442913-178442914	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.875A>G; p.D292G; 1:178442676-178442676	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.875A>G; p.D292G; 1:178442676-178442676	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.790G>A; p.G264R; 1:178441564-178441564	skin	malignant_melanoma	Substitution - Missense
c.1942G>T; p.A648S; 1:178452639-178452639	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1741G>T; p.E581*; 1:178452438-178452438	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1526A>G; p.E509G; 1:178445615-178445615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1526A>G; p.E509G; 1:178445615-178445615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1078C>T; p.H360Y; 1:178442879-178442879	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.135G>T; p.W45C; 1:178094681-178094681	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2318C>T; p.S773F; 1:178456860-178456860	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1904G>A; p.R635Q; 1:178452601-178452601	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2221G>T; p.D741Y; 1:178456763-178456763	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.784T>C; p.L262L; 1:178441558-178441558	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.626G>A; p.R209H; 1:178439427-178439427	breast	carcinoma	Substitution - Missense
c.3715C>T; p.R1239W; 1:178473144-178473144	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.549G>A; p.R183R; 1:178420549-178420549	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1480G>A; p.D494N; 1:178445569-178445569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.868A>G; p.N290D; 1:178441642-178441642	ovary	other; neoplasm	Substitution - Missense
c.2678G>A; p.R893K; 1:178458003-178458003	skin	malignant_melanoma	Substitution - Missense
c.1937A>C; p.N646T; 1:178452634-178452634	breast	carcinoma	Substitution - Missense
c.1615G>T; p.E539*; 1:178451612-178451612	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.940_941insA; p.K316fs*9; 1:178442741-178442742	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.1995delT; p.L667fs*1; 1:178454486-178454486	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.136G>A; p.V46I; 1:178094682-178094682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.160C>T; p.P54S; 1:178283575-178283575	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.831C>G; p.D277E; 1:178441605-178441605	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3155C>T; p.S1052F; 1:178458480-178458480	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1193C>T; p.P398L; 1:178442994-178442994	skin	malignant_melanoma	Substitution - Missense
c.374A>G; p.E125G; 1:178300089-178300089	liver	carcinoma	Substitution - Missense
c.1193C>T; p.P398L; 1:178442994-178442994	skin	malignant_melanoma	Substitution - Missense
c.374A>G; p.E125G; 1:178300089-178300089	liver	carcinoma	Substitution - Missense
c.2949A>G; p.R983R; 1:178458274-178458274	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.213G>C; p.T71T; 1:178283628-178283628	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.599C>T; p.S200F; 1:178420599-178420599	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3002G>A; p.R1001Q; 1:178458327-178458327	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1573+2T>C; p.?; 1:178445664-178445664	stomach	carcinoma; adenocarcinoma	Unknown
c.1465C>T; p.R489C; 1:178445554-178445554	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2828G>A; p.R943K; 1:178458153-178458153	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.545A>T; p.K182M; 1:178420545-178420545	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.173G>A; p.R58H; 1:178283588-178283588	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.3399C>A; p.S1133S; 1:178465964-178465964	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2389_2397delGACAACACA; p.N798_D800delNTD; 1:178457714-178457722	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.2389G>T; p.D797Y; 1:178457714-178457714	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3280C>G; p.L1094V; 1:178464338-178464338	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2632C>T; p.Q878*; 1:178457957-178457957	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.706G>C; p.G236R; 1:178439507-178439507	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.459A>C; p.S153S; 1:178390155-178390155	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.535G>T; p.G179C; 1:178420535-178420535	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3082G>A; p.G1028R; 1:178458407-178458407	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2102G>A; p.R701Q; 1:178454593-178454593	bone; scapula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.3252C>T; p.S1084S; 1:178464310-178464310	skin	malignant_melanoma	Substitution - coding silent
c.3260A>G; p.E1087G; 1:178464318-178464318	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3082G>A; p.G1028R; 1:178458407-178458407	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.919G>T; p.E307*; 1:178442720-178442720	liver	carcinoma	Substitution - Nonsense
c.919G>T; p.E307*; 1:178442720-178442720	liver	carcinoma	Substitution - Nonsense
c.1909C>G; p.L637V; 1:178452606-178452606	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2955A>G; p.I985M; 1:178458280-178458280	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2472_2473GG>TA; p.K824_D825>NN; 1:178457797-178457798	skin; head_neck	carcinoma; squamous_cell_carcinoma	Complex - compound substitution
c.3681C>T; p.T1227T; 1:178473110-178473110	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2249C>T; p.T750M; 1:178456791-178456791	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1606G>A; p.E536K; 1:178451603-178451603	ovary	other; neoplasm	Substitution - Missense
c.1525G>A; p.E509K; 1:178445614-178445614	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1589C>T; p.A530V; 1:178451586-178451586	skin	malignant_melanoma	Substitution - Missense
c.1589C>T; p.A530V; 1:178451586-178451586	skin	malignant_melanoma	Substitution - Missense
c.1520C>T; p.S507F; 1:178445609-178445609	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1472G>T; p.G491V; 1:178445561-178445561	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.305A>G; p.Q102R; 1:178300020-178300020	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2361T>G; p.D787E; 1:178457686-178457686	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1430A>G; p.D477G; 1:178445519-178445519	large_intestine; colon	NS	Substitution - Missense
c.2697C>A; p.A899A; 1:178458022-178458022	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3585G>C; p.K1195N; 1:178467361-178467361	breast	carcinoma	Substitution - Missense
c.276G>T; p.E92D; 1:178283691-178283691	breast	carcinoma	Substitution - Missense
c.2210G>A; p.R737H; 1:178456752-178456752	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3695C>T; p.A1232V; 1:178473124-178473124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3695C>T; p.A1232V; 1:178473124-178473124	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2507G>T; p.S836I; 1:178457832-178457832	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1976A>G; p.Y659C; 1:178454467-178454467	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3657C>T; p.I1219I; 1:178473086-178473086	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.955T>A; p.C319S; 1:178442756-178442756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2550G>A; p.V850V; 1:178457875-178457875	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1817C>G; p.S606*; 1:178452514-178452514	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1104G>C; p.K368N; 1:178442905-178442905	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1104G>C; p.K368N; 1:178442905-178442905	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3001C>T; p.R1001*; 1:178458326-178458326	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2430G>T; p.L810L; 1:178457755-178457755	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.253G>T; p.V85L; 1:178283668-178283668	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2634G>A; p.Q878Q; 1:178457959-178457959	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.76G>A; p.V26I; 1:178094622-178094622	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1652T>C; p.I551T; 1:178451649-178451649	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1097A>G; p.E366G; 1:178442898-178442898	pancreas	carcinoma	Substitution - Missense
c.2494C>T; p.P832S; 1:178457819-178457819	skin	malignant_melanoma	Substitution - Missense
c.1536C>T; p.L512L; 1:178445625-178445625	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3027T>G; p.G1009G; 1:178458352-178458352	breast	carcinoma	Substitution - coding silent
c.989G>A; p.R330H; 1:178442790-178442790	breast	carcinoma	Substitution - Missense
c.2595A>T; p.G865G; 1:178457920-178457920	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2388G>A; p.Q796Q; 1:178457713-178457713	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.3223C>G; p.Q1075E; 1:178464281-178464281	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1533C>A; p.Y511*; 1:178445622-178445622	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.3068C>A; p.S1023Y; 1:178458393-178458393	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3733C>T; p.R1245C; 1:178473162-178473162	skin	malignant_melanoma	Substitution - Missense
c.2657C>T; p.P886L; 1:178457982-178457982	skin	malignant_melanoma	Substitution - Missense
c.2235A>C; p.S745S; 1:178456777-178456777	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1278G>T; p.L426L; 1:178443079-178443079	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2294G>T; p.S765I; 1:178456836-178456836	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2504G>A; p.R835Q; 1:178457829-178457829	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2504G>A; p.R835Q; 1:178457829-178457829	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.200C>T; p.T67I; 1:178283615-178283615	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.200C>T; p.T67I; 1:178283615-178283615	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1573G>T; p.G525W; 1:178445662-178445662	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1384G>T; p.A462S; 1:178443185-178443185	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.383C>T; p.P128L; 1:178300098-178300098	skin	malignant_melanoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]