Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

9486

Name

CHST10

Synonymous

carbohydrate sulfotransferase 10;CHST10;carbohydrate sulfotransferase 10

Definition

HNK-1 sulfotransferase|huHNK-1ST

Position

2q11.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.13.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.961G>T; p.E321*; 2:100393355-100393355

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.27C>T; p.A9A; 2:100406649-100406649

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.498G>A; p.R166R; 2:100395544-100395544

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.498G>A; p.R166R; 2:100395544-100395544

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.235C>A; p.L79M; 2:100398100-100398100

 livercarcinomaSubstitution - Missense

c.235C>A; p.L79M; 2:100398100-100398100

 livercarcinomaSubstitution - Missense

c.535T>A; p.L179M; 2:100393781-100393781

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.720C>T; p.F240F; 2:100393596-100393596

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.720C>T; p.F240F; 2:100393596-100393596

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.720C>T; p.F240F; 2:100393596-100393596

 skinmalignant_melanomaSubstitution - coding silent

c.251G>A; p.R84H; 2:100398084-100398084

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.686G>A; p.R229Q; 2:100393630-100393630

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.561T>C; p.I187I; 2:100393755-100393755

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.317C>T; p.S106F; 2:100398018-100398018

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.107G>A; p.S36N; 2:100402649-100402649

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.107G>A; p.S36N; 2:100402649-100402649

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.276C>A; p.C92*; 2:100398059-100398059

 ovarycarcinoma; serous_carcinomaSubstitution - Nonsense

c.276C>A; p.C92*; 2:100398059-100398059

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.418G>T; p.V140F; 2:100397917-100397917

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.623G>A; p.R208Q; 2:100393693-100393693

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.733G>A; p.G245S; 2:100393583-100393583

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.877A>G; p.I293V; 2:100393439-100393439

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.767T>G; p.F256C; 2:100393549-100393549

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.300C>A; p.L100L; 2:100398035-100398035

 skinmalignant_melanomaSubstitution - coding silent

c.742A>T; p.N248Y; 2:100393574-100393574

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.719T>C; p.F240S; 2:100393597-100393597

 skinmalignant_melanomaSubstitution - Missense

c.300C>A; p.L100L; 2:100398035-100398035

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1018G>A; p.E340K; 2:100393298-100393298

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.820G>T; p.E274*; 2:100393496-100393496

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.488G>A; p.G163D; 2:100395554-100395554

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.550A>G; p.K184E; 2:100393766-100393766

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - Missense

c.890C>A; p.A297D; 2:100393426-100393426

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.497G>A; p.R166Q; 2:100395545-100395545

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.702delG; p.I235fs*18; 2:100393614-100393614

 large_intestine; rectumcarcinoma; adenocarcinomaDeletion - Frameshift

c.1041G>T; p.G347G; 2:100393275-100393275

 central_nervous_system; braingliomaSubstitution - coding silent

c.453C>T; p.I151I; 2:100395589-100395589

 skinmalignant_melanomaSubstitution - coding silent

c.15G>A; p.W5*; 2:100406661-100406661

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.681G>T; p.R227S; 2:100393635-100393635

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.996C>A; p.I332I; 2:100393320-100393320

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.100+4C>T; p.?; 2:100406572-100406572

 pancreascarcinomaUnknown

c.759C>T; p.D253D; 2:100393557-100393557

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1048A>G; p.K350E; 2:100393268-100393268

 skinmalignant_melanomaSubstitution - Missense

c.47T>C; p.F16S; 2:100406629-100406629

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.276C>T; p.C92C; 2:100398059-100398059

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.584_585delTT; p.L195fs*5; 2:100393731-100393732

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.70T>C; p.F24L; 2:100406606-100406606

 skinmalignant_melanomaSubstitution - Missense

c.184G>C; p.E62Q; 2:100402572-100402572

 skinmalignant_melanomaSubstitution - Missense

c.740C>T; p.P247L; 2:100393576-100393576

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.225C>T; p.L75L; 2:100398110-100398110

 skinmalignant_melanomaSubstitution - coding silent

c.389G>T; p.G130V; 2:100397946-100397946

 livercarcinomaSubstitution - Missense

c.794C>T; p.T265M; 2:100393522-100393522

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.724C>T; p.R242C; 2:100393592-100393592

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.736G>A; p.D246N; 2:100393580-100393580

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.844C>T; p.H282Y; 2:100393472-100393472

 thyroidcarcinomaSubstitution - Missense

c.1A>G; p.M1V; 2:100406675-100406675

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.721G>A; p.V241M; 2:100393595-100393595

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.961G>C; p.E321Q; 2:100393355-100393355

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.568G>T; p.D190Y; 2:100393748-100393748

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.439T>A; p.S147T; 2:100395603-100395603

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1017C>T; p.F339F; 2:100393299-100393299

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1017C>T; p.F339F; 2:100393299-100393299

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.110C>T; p.A37V; 2:100402646-100402646

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.275G>T; p.C92F; 2:100398060-100398060

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.577G>A; p.E193K; 2:100393739-100393739

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.577G>A; p.E193K; 2:100393739-100393739

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.577G>A; p.E193K; 2:100393739-100393739

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.577G>A; p.E193K; 2:100393739-100393739

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.685C>T; p.R229W; 2:100393631-100393631

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.685C>T; p.R229W; 2:100393631-100393631

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.785A>T; p.H262L; 2:100393531-100393531

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.850G>A; p.E284K; 2:100393466-100393466

 pancreascarcinomaSubstitution - Missense

c.850G>A; p.E284K; 2:100393466-100393466

 pancreascarcinomaSubstitution - Missense

c.294G>A; p.K98K; 2:100398041-100398041

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.870C>T; p.A290A; 2:100393446-100393446

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.77C>T; p.T26M; 2:100406599-100406599

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.77C>T; p.T26M; 2:100406599-100406599

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.918G>A; p.P306P; 2:100393398-100393398

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.918G>A; p.P306P; 2:100393398-100393398

 thyroidcarcinomaSubstitution - coding silent

c.918G>A; p.P306P; 2:100393398-100393398

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1001G>A; p.R334H; 2:100393315-100393315

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.929C>T; p.P310L; 2:100393387-100393387

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.455C>T; p.P152L; 2:100395587-100395587

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.929C>T; p.P310L; 2:100393387-100393387

 skinmalignant_melanomaSubstitution - Missense

c.929C>T; p.P310L; 2:100393387-100393387

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.929C>T; p.P310L; 2:100393387-100393387

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1000C>T; p.R334C; 2:100393316-100393316

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.659G>A; p.G220D; 2:100393657-100393657

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.144G>A; p.P48P; 2:100402612-100402612

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.302C>T; p.S101L; 2:100398033-100398033

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.302C>T; p.S101L; 2:100398033-100398033

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

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