Entrez Gene

Basic Information
Gene ID	9667
Name	SAFB2
Synonymous	scaffold attachment factor B2;SAFB2;scaffold attachment factor B2
Definition	SAF-B2
Position	19p13.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.20.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2067C>T; p.R689R; 19:5594031-5594031	pancreas	carcinoma	Substitution - coding silent
c.1731G>A; p.S577S; 19:5598844-5598844	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1731G>A; p.S577S; 19:5598844-5598844	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2824C>T; p.H942Y; 19:5587281-5587281	breast	carcinoma	Substitution - Missense
c.1782+3G>A; p.?; 19:5598790-5598790	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1552A>G; p.I518V; 19:5604590-5604590	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.254C>T; p.S85L; 19:5621329-5621329	breast	carcinoma	Substitution - Missense
c.1607delA; p.K536fs*15; 19:5600213-5600213	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1607delA; p.K536fs*15; 19:5600213-5600213	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1607delA; p.K536fs*15; 19:5600213-5600213	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.634+2T>C; p.?; 19:5612538-5612538	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2574G>A; p.Q858Q; 19:5587932-5587932	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.469G>A; p.D157N; 19:5616206-5616206	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2412C>T; p.R804R; 19:5590391-5590391	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1999C>T; p.R667C; 19:5594099-5594099	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1281C>T; p.F427F; 19:5610010-5610010	skin	malignant_melanoma	Substitution - coding silent
c.2765T>C; p.L922P; 19:5587340-5587340	thyroid	other; neoplasm	Substitution - Missense
c.2639-4C>T; p.?; 19:5587771-5587771	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.1426C>T; p.R476*; 19:5604807-5604807	large_intestine; colon	carcinoma	Substitution - Nonsense
c.1426C>T; p.R476*; 19:5604807-5604807	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2834C>T; p.P945L; 19:5587271-5587271	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1756A>C; p.K586Q; 19:5598819-5598819	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1839G>A; p.S613S; 19:5595441-5595441	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1153A>C; p.K385Q; 19:5610681-5610681	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2628C>T; p.A876A; 19:5587878-5587878	skin	malignant_melanoma	Substitution - coding silent
c.2509C>T; p.L837L; 19:5590294-5590294	skin	malignant_melanoma	Substitution - coding silent
c.2263C>T; p.R755C; 19:5592832-5592832	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2358T>G; p.G786G; 19:5591784-5591784	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2044A>C; p.M682L; 19:5594054-5594054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.165_166CC>TT; p.(=); 19:5622550-5622551	cervix	carcinoma; squamous_cell_carcinoma	Unknown
c.381C>T; p.G127G; 19:5616294-5616294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.417G>A; p.V139V; 19:5616258-5616258	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2249T>C; p.M750T; 19:5592846-5592846	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2471delG; p.G824fs*8; 19:5590332-5590332	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.158A>T; p.K53M; 19:5622558-5622558	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2471delG; p.G824fs*8; 19:5590332-5590332	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.346A>G; p.M116V; 19:5616329-5616329	liver	carcinoma	Substitution - Missense
c.2471delG; p.G824fs*8; 19:5590332-5590332	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.346A>G; p.M116V; 19:5616329-5616329	liver	carcinoma	Substitution - Missense
c.2471delG; p.G824fs*8; 19:5590332-5590332	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2471_2472insG; p.Y825fs*9; 19:5590331-5590332	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Insertion - Frameshift
c.189G>A; p.A63A; 19:5621394-5621394	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2743C>A; p.H915N; 19:5587362-5587362	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2785A>T; p.S929C; 19:5587320-5587320	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.2093G>A; p.R698H; 19:5594005-5594005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2239C>T; p.R747C; 19:5592856-5592856	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2214T>G; p.D738E; 19:5592881-5592881	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1465G>T; p.G489W; 19:5604677-5604677	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2663C>T; p.P888L; 19:5587743-5587743	skin	malignant_melanoma	Substitution - Missense
c.2760C>G; p.G920G; 19:5587345-5587345	thyroid	other; neoplasm	Substitution - coding silent
c.1560-1G>C; p.?; 19:5600261-5600261	urinary_tract; bladder	carcinoma	Unknown
c.1465G>T; p.G489W; 19:5604677-5604677	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2644G>A; p.E882K; 19:5587762-5587762	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834delC; p.P945fs*>9; 19:5587271-5587271	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1787C>T; p.S596F; 19:5595493-5595493	skin	malignant_melanoma	Substitution - Missense
c.1375G>A; p.D459N; 19:5604858-5604858	breast	carcinoma	Substitution - Missense
c.2626G>A; p.A876T; 19:5587880-5587880	pancreas	carcinoma	Substitution - Missense
c.1297-2A>T; p.?; 19:5604938-5604938	stomach	carcinoma; adenocarcinoma	Unknown
c.2520C>T; p.P840P; 19:5590283-5590283	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.605C>T; p.P202L; 19:5613466-5613466	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.220A>G; p.I74V; 19:5621363-5621363	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2279G>A; p.R760Q; 19:5592816-5592816	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1276C>T; p.L426F; 19:5610015-5610015	skin	malignant_melanoma	Substitution - Missense
c.405C>T; p.D135D; 19:5616270-5616270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1495G>A; p.E499K; 19:5604647-5604647	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1495G>A; p.E499K; 19:5604647-5604647	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1495G>A; p.E499K; 19:5604647-5604647	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1617C>T; p.D539D; 19:5600203-5600203	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1279T>G; p.F427V; 19:5610012-5610012	skin	malignant_melanoma	Substitution - Missense
c.1944G>A; p.E648E; 19:5594154-5594154	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1191A>C; p.E397D; 19:5610643-5610643	liver	carcinoma	Substitution - Missense
c.1191A>C; p.E397D; 19:5610643-5610643	liver	carcinoma	Substitution - Missense
c.1262C>T; p.T421M; 19:5610029-5610029	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2042G>A; p.R681H; 19:5594056-5594056	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2446C>T; p.R816W; 19:5590357-5590357	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	thyroid	other; neoplasm	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	liver	carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	prostate	carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2848A>C; p.T950P; 19:5587257-5587257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1681A>G; p.T561A; 19:5600139-5600139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2119C>T; p.R707C; 19:5593979-5593979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1682C>T; p.T561I; 19:5600138-5600138	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.406G>A; p.E136K; 19:5616269-5616269	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2360C>T; p.S787L; 19:5591782-5591782	skin	malignant_melanoma	Substitution - Missense
c.2377G>C; p.D793H; 19:5591765-5591765	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2854C>T; p.R952C; 19:5587251-5587251	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2426G>A; p.G809E; 19:5590377-5590377	breast	carcinoma	Substitution - Missense
c.1832T>G; p.I611S; 19:5595448-5595448	liver	carcinoma	Substitution - Missense
c.1802G>T; p.R601L; 19:5595478-5595478	breast	carcinoma	Substitution - Missense
c.1832T>G; p.I611S; 19:5595448-5595448	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2344G>A; p.D782N; 19:5592751-5592751	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2625C>T; p.H875H; 19:5587881-5587881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1525G>A; p.D509N; 19:5604617-5604617	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2764C>T; p.L922L; 19:5587341-5587341	thyroid	other; neoplasm	Substitution - coding silent
c.2508delG; p.L837fs*18; 19:5590295-5590295	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2834_2835insC; p.Y946fs*>9; 19:5587270-5587271	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1240C>T; p.L414L; 19:5610051-5610051	skin	malignant_melanoma	Substitution - coding silent
c.2343C>T; p.I781I; 19:5592752-5592752	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2834_2835insC; p.Y946fs*>9; 19:5587270-5587271	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.180C>G; p.L60L; 19:5622536-5622536	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2451C>T; p.D817D; 19:5590352-5590352	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2337C>T; p.H779H; 19:5592758-5592758	skin	malignant_melanoma	Substitution - coding silent
c.1444A>T; p.K482*; 19:5604789-5604789	stomach	adenocarcinoma	Substitution - Nonsense
c.2185C>T; p.R729W; 19:5593913-5593913	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2579G>T; p.R860L; 19:5587927-5587927	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.621C>T; p.S207S; 19:5612553-5612553	skin	malignant_melanoma	Substitution - coding silent
c.419C>T; p.A140V; 19:5616256-5616256	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.189G>C; p.A63A; 19:5621394-5621394	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2001C>A; p.R667R; 19:5594097-5594097	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.214G>A; p.D72N; 19:5621369-5621369	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.370C>T; p.Q124*; 19:5616305-5616305	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1545G>T; p.E515D; 19:5604597-5604597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.170T>G; p.M57R; 19:5622546-5622546	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1328G>A; p.R443H; 19:5604905-5604905	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1328G>A; p.R443H; 19:5604905-5604905	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2858A>T; p.Y953F; 19:5587247-5587247	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.588G>A; p.L196L; 19:5613483-5613483	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2580C>T; p.R860R; 19:5587926-5587926	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2580C>T; p.R860R; 19:5587926-5587926	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.439T>A; p.F147I; 19:5616236-5616236	skin	malignant_melanoma	Substitution - Missense
c.1367C>T; p.S456L; 19:5604866-5604866	prostate	adenoma	Substitution - Missense
c.395G>A; p.S132N; 19:5616280-5616280	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.5C>T; p.A2V; 19:5622711-5622711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.607-7delT; p.?; 19:5612574-5612574	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.251A>T; p.K84M; 19:5621332-5621332	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.581C>A; p.S194*; 19:5613490-5613490	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1902C>T; p.R634R; 19:5595378-5595378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2581G>A; p.A861T; 19:5587925-5587925	breast	carcinoma	Substitution - Missense
c.2835_2837delGTA; p.Y946delY; 19:5587268-5587270	breast	carcinoma	Deletion - In frame
c.2338G>A; p.A780T; 19:5592757-5592757	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2338G>A; p.A780T; 19:5592757-5592757	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.553G>T; p.E185*; 19:5613518-5613518	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2338G>A; p.A780T; 19:5592757-5592757	skin	malignant_melanoma	Substitution - Missense
c.2641G>A; p.G881S; 19:5587765-5587765	soft_tissue; fibrous_tissue_and_uncertain_o	dermatofibrosarcoma_protuberans	Substitution - Missense
c.1324G>A; p.A442T; 19:5604909-5604909	stomach	adenocarcinoma	Substitution - Missense
c.553G>T; p.E185*; 19:5613518-5613518	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2819A>C; p.H940P; 19:5587286-5587286	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2819A>C; p.H940P; 19:5587286-5587286	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2819A>C; p.H940P; 19:5587286-5587286	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2819A>C; p.H940P; 19:5587286-5587286	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2684C>T; p.A895V; 19:5587722-5587722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2819A>C; p.H940P; 19:5587286-5587286	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2819A>C; p.H940P; 19:5587286-5587286	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2103G>A; p.E701E; 19:5593995-5593995	skin	malignant_melanoma	Substitution - coding silent
c.112C>G; p.L38V; 19:5622604-5622604	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1801C>T; p.R601C; 19:5595479-5595479	skin	malignant_melanoma	Substitution - Missense
c.1502A>G; p.K501R; 19:5604640-5604640	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2601C>T; p.D867D; 19:5587905-5587905	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2823T>C; p.P941P; 19:5587282-5587282	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1443G>T; p.E481D; 19:5604790-5604790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.132G>A; p.K44K; 19:5622584-5622584	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.296G>A; p.G99D; 19:5616465-5616465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.606G>A; p.P202P; 19:5613465-5613465	liver	carcinoma	Substitution - coding silent
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.606G>A; p.P202P; 19:5613465-5613465	liver	carcinoma	Substitution - coding silent
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2837A>C; p.Y946S; 19:5587268-5587268	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1709G>A; p.R570Q; 19:5598866-5598866	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2153A>G; p.Q718R; 19:5593945-5593945	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.1657G>A; p.G553R; 19:5600163-5600163	pancreas	carcinoma	Substitution - Missense
c.2162A>G; p.Y721C; 19:5593936-5593936	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2833_2834delCC; p.P945fs*>9; 19:5587271-5587272	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.2503C>T; p.R835W; 19:5590300-5590300	pancreas	carcinoma	Substitution - Missense
c.2209C>T; p.R737*; 19:5592886-5592886	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.2503C>T; p.R835W; 19:5590300-5590300	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1094C>G; p.P365R; 19:5611171-5611171	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.418G>A; p.A140T; 19:5616257-5616257	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1342C>T; p.R448*; 19:5604891-5604891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2563G>A; p.E855K; 19:5587943-5587943	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2276C>T; p.P759L; 19:5592819-5592819	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1716C>T; p.V572V; 19:5598859-5598859	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1165G>T; p.D389Y; 19:5610669-5610669	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2349G>A; p.R783R; 19:5591793-5591793	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2000G>A; p.R667H; 19:5594098-5594098	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2269G>C; p.D757H; 19:5592826-5592826	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1959C>T; p.A653A; 19:5594139-5594139	skin	malignant_melanoma	Substitution - coding silent
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.221T>C; p.I74T; 19:5621362-5621362	breast	carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2846T>C; p.F949S; 19:5587259-5587259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.620C>A; p.S207Y; 19:5612554-5612554	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2428C>T; p.P810S; 19:5590375-5590375	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2708G>A; p.R903Q; 19:5587397-5587397	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2264G>A; p.R755H; 19:5592831-5592831	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1964A>G; p.H655R; 19:5594134-5594134	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2264G>A; p.R755H; 19:5592831-5592831	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]