Entrez Gene

Basic Information
Gene ID	10253
Name	SPRY2
Synonymous	hSPRY2;sprouty homolog 2 (Drosophila);SPRY2;sprouty homolog 2 (Drosophila)
Definition	protein sprouty homolog 2\|sprouty 2\|spry-2
Position	13q31.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
c-Cbl(h) + Sprouty2(h) <==> c-Cbl(h):Sprouty2(h) (binding)
Sprouty2(h) + ATP --Src(m.s.){pY416}--> Sprouty2(h){pY55} + ADP (phosphorylation)
Sprouty2(h) + ATP --Fyn(m.s.)--> Sprouty2(h){pY55} + ADP (phosphorylation)
Sprouty2(h) + ATP --Src(h){pY419}--> Sprouty2(h){pY} + ADP (phosphorylation)
PLSCR1(h) + Sprouty2(h) <==> PLSCR1(h):Sprouty2(h) (binding)
TRAF2(h) + Sprouty2(h) <==> TRAF2(h):Sprouty2(h) (binding)
GRIN2(h) + Sprouty2(h) <==> GRIN2(h):Sprouty2(h) (binding)
Sprouty2(h) + TSRC1(h) <==> Sprouty2(h):TSRC1(h) (binding)
Sprouty2(h) + KAP4.12(h) <==> Sprouty2(h):KAP4.12(h) (binding)
Sprouty2(h) + TRIM51(h) <==> Sprouty2(h):TRIM51(h) (binding)
Sprouty2(h) --> ERK1(h){pT202}{pY204} (decrease of phosphorylation)
Sprouty2(h) --> ERK2(h){pT185}{pY187} (decrease of phosphorylation)
Sprouty2(h) + B-Raf(h) <==> Sprouty2(h):B-Raf(h) (binding)
SPRY2(h) --> Sprouty2(h) (expression).
Sprouty2(h) + CIN85(m.s.) <==> Sprouty2(h):CIN85(m.s.) (binding)
c-Cbl(ha) + Sprouty2(h) + CIN85(ha) <==> c-Cbl(ha):Sprouty2(h):CIN85(ha) (binding)
c-Cbl(ha) + Sprouty2(h) <==> c-Cbl(ha):Sprouty2(h) (binding)
Sprouty2(h) + CIN85(ha) <==> Sprouty2(h):CIN85(ha) (binding)
SPRY2(h) --> Sprouty2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
227	Phosphotyrosine	15637081	Phospho.ELM 6.0
55	Phosphotyrosine (Src)	15637081;16000370;12593795;15564375;12815057	Phospho.ELM 6.0