Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10413

Name

YAP1

Synonymous

COB1|YAP|YAP2|YAP65|YKI;Yes-associated protein 1;YAP1;Yes-associated protein 1

Definition

65 kDa Yes-associated protein|protein yorkie homolog|transcriptional coactivator YAP1|yes-associated protein 2|yes-associated protein YAP65 homolog|yorkie homolog

Position

11q13

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

p73alpha(mo) + YAP(h) <==> p73alpha(mo):YAP(h) (binding)
p73beta(m) + YAP(h) <==> p73beta(m):YAP(h) (binding)
p63alpha(m) + YAP(h) <==> p63alpha(m):YAP(h) (binding)
Smad7(m) + YAP(h) <==> Smad7(m):YAP(h) (binding)
YAP(h) + ATP --> YAP(h){pS127} + ADP (phosphorylation)
YAP1(h) --> YAP(h) (expression).
YAP(h) + SAF-A(h) <==> YAP(h):SAF-A(h) (binding)
YAP(h) + 14-3-3(h) <==> YAP(h):14-3-3(h) (binding)
YAP(h) --> YAP(h) (translocation)
ErbB4(m.s.) + YAP(h) <==> ErbB4(m.s.):YAP(h) (binding)
YAP(h) + ErbB4-CTF(h) <==> YAP(h):ErbB4-CTF(h) (binding)
YAP1(h) --> YAP(h) (expression).
YAP(h) --> YAP(h) (translocation)

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

109Phosphoserine.Swiss-Prot 53.0
110Phosphothreonine.Swiss-Prot 53.0
127Phosphoserine (By similarity).Swiss-Prot 53.0
128Phosphoserine (By similarity).Swiss-Prot 53.0
143Phosphothreonine.Swiss-Prot 53.0
154Phosphothreonine.Swiss-Prot 53.0
238Phosphoserine.Swiss-Prot 53.0
347Phosphoserine15302935Phospho.ELM 6.0
348Phosphothreonine15302935Phospho.ELM 6.0
109Phosphoserine17081983Phospho.ELM 6.0
138Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr11

Promoter: 101485041 - 101487041Agilent_014791

chr11

Promoter: 101485041 - 101487041GSE27584

chr11

Promoter: 101485041 - 101487041Agilent_014791_44K


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