Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1050

Name

CEBPA

Synonymous

C/EBP-alpha|CEBP;CCAAT/enhancer binding protein (C/EBP), alpha;CEBPA;CCAAT/enhancer binding protein (C/EBP), alpha

Definition

CCAAT/enhancer-binding protein alpha

Position

19q13.1

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

C/EBPalpha(h) --> APOA2(h) (DNA binding).
C/EBPalpha(h) --> factor IX(h) (DNA binding).
C/EBPalpha(h) --> OTC(r) (DNA binding).
C/EBPalpha(h) --> TF(h) (DNA binding).
C/EBPalpha(h) --> apoB(h) (DNA binding).
C/EBPalpha(h) --> SAA1(r) (DNA binding).
C/EBPalpha(h) --> FGA(h) (DNA binding).
C/EBPalpha(h) --> ICAM1(h) (DNA binding).
C/EBPalpha(h) + C/EBPbeta(p35)(m) <==> C/EBPalpha(h):C/EBPbeta(p35)(m) (binding).
C/EBPalpha(h) + C/EBPbeta(LAP)(r) <==> C/EBPalpha(h):C/EBPbeta(LAP)(r) (binding).
C/EBPalpha(h) + C/EBPbeta(h) <==> C/EBPalpha(h):C/EBPbeta(h) (binding).
CHOP-10(m) + C/EBPalpha(h) <==> CHOP-10(m):C/EBPalpha(h) (binding).
C/EBPgamma(m) + C/EBPalpha(h) <==> C/EBPgamma(m):C/EBPalpha(h) (binding).
C/EBPalpha(h) + C/EBPalpha(h) <==> C/EBPalpha(h):C/EBPalpha(h) (binding).
C/EBPalpha(h) + C/EBPdelta(h) <==> C/EBPalpha(h):C/EBPdelta(h) (binding).
C/EBPalpha(h) + C/EBPdelta(m) <==> C/EBPalpha(h):C/EBPdelta(m) (binding).
C/EBPalpha(h) + C/EBPdelta(r) <==> C/EBPalpha(h):C/EBPdelta(r) (binding).
C/EBPalpha(h) + ATF-4(h) <==> C/EBPalpha(h):ATF-4(h) (binding).
C/EBPalpha(h) + NF-AT3(h) <==> NF-AT3(h):C/EBPalpha(h) (assembly; binding; interaction)
NF-AT1(h) + C/EBPalpha(h) <==> NF-AT1(h):C/EBPalpha(h) (binding; assembly; interaction)
C/EBPalpha(h) --> IL10(h) (DNA binding; transactivation).
C/EBPalpha(h) --> SERPINC1(h) (DNA binding).
C/EBPalpha(h) + ATP --ERK(h)--> C/EBPalpha(h){pS21} + ADP (phosphorylation)
C/EBPalpha(h) --> DEFA1(h) (transactivation; DNA binding)
C/EBPalpha(h) --> DEFA3(h) (transactivation; DNA binding)
Cdk2(h) + C/EBPalpha(h) <==> Cdk2(h):C/EBPalpha(h) (binding)
Cdk4(h) + C/EBPalpha(h) <==> Cdk4(h):C/EBPalpha(h) (binding)
AR(h) + C/EBPalpha(h) <==> AR(h):C/EBPalpha(h) (binding)
C/EBPalpha(h) + ASC-2(h) <==> C/EBPalpha(h):ASC-2(h) (binding)
NF-kappaB1-p50(h) + C/EBPalpha(h) <==> NF-kappaB1-p50(h):C/EBPalpha(h) (binding)
2 C/EBPalpha(h) <==> (C/EBPalpha(h))2 (oligomerization)
NF-IL6-1(h) + C/EBPalpha(h) <==> NF-IL6-1(h):C/EBPalpha(h) (binding)
C/EBPalpha(h) + C/EBPgamma(h) <==> C/EBPalpha(h):C/EBPgamma(h) (binding)
C/EBPalpha(h) + C/EBPdelta(h) <==> C/EBPalpha(h):C/EBPdelta(h) (binding)
C/EBPalpha(h) + CHOP-10(h) <==> C/EBPalpha(h):CHOP-10(h) (binding)
C/EBPalpha(h) + ATF-4(h) <==> C/EBPalpha(h):ATF-4(h) (binding)
C/EBPalpha(h) + ATF5(h) <==> C/EBPalpha(h):ATF5(h) (binding)
C/EBPalpha(h) + ATFa-isoform3(h) <==> C/EBPalpha(h):ATFa-isoform3(h) (binding)
C/EBPalpha(h) + CREBPA-Alpha(h) <==> C/EBPalpha(h):CREBPA-Alpha(h) (binding)
C/EBPalpha(h) + B-ATF(h) <==> C/EBPalpha(h):B-ATF(h) (binding)
batf3(h) + C/EBPalpha(h) <==> batf3(h):C/EBPalpha(h) (binding)
C/EBPalpha(h) + cebpe(h) <==> C/EBPalpha(h):cebpe(h) (binding)
C/EBPalpha(h) --> G6pc(r) (DNA binding).
NF-YA(h) + C/EBPalpha(h) <==> NF-YA(h):C/EBPalpha(h) (binding)
NF-YB(m.s.) + C/EBPalpha(h) <==> NF-YB(m.s.):C/EBPalpha(h) (binding)
C/EBPalpha(h) --> CSF1(h) (DNA binding).
C/EBPalpha(h) --> ALOX5AP(h) (DNA binding; transactivation).
C/EBPalpha(h) --> PTGS2(h) (DNA binding).
C/EBPalpha(h) --> CSF2RA(h) (DNA binding).
C/EBPalpha(h) --> CYP3A4(h) (DNA binding).
C/EBPalpha(h) --> S100A9(h) (DNA binding).
C/EBPalpha(h) --> LTF(h) (DNA binding; transactivation).
C/EBPalpha(h) --> IVL(h) (DNA binding).
C/EBPalpha(h) + c-Jun(h) <==> C/EBPalpha(h):c-Jun(h) (binding)
C/EBPalpha(h) --> SERPINE1(h) (DNA binding).
C/EBPalpha(h) --> CYP19A1(h) (DNA binding).
C/EBPalpha(h) --> CYP2A13(h) (DNA binding).
C/EBPalpha(h) --> TLR9(h) (DNA binding).
C/EBPalpha(h) --> BCL2(h) (transactivation)
C/EBPalpha(h) --> Sfpi1(m) (DNA binding).
C/EBPalpha(h) --> G-CSF(h) (DNA binding).
C/EBPalpha(h) --> STAR(h) (DNA binding; transactivation).
C/EBPalpha(h) --> CES1(h) (DNA binding; transactivation).
C/EBPalpha(h) --> CHI3L1(h) (DNA binding).
C/EBPalpha(h) --> CD14(h) (DNA binding; transactivation).
C/EBPalpha(h) --> GAPDH(h) (DNA binding).
C/EBPalpha(h) --> AHSG(h) (DNA binding).
C/EBPalpha(h) --> CRP(h) (DNA binding).
C/EBPalpha(h) --> PRTN3(h) (DNA binding).
C/EBPalpha(h) --> SLC11A1(h) (DNA binding; transactivation).
CEBPA(h) --> C/EBPalpha(h) (expression).
IL-17A(h) --> C/EBPalpha(h) (increase of abundance)
C/EBPalpha(h) --> Serpina1a(m) (DNA binding).
C/EBPalpha(h) --> CRP(h) (DNA binding).
C/EBPalpha(h) --> HBV enhancer(HBV) (DNA binding; transregulation).
C/EBPalpha(h) --> CETP(h) (DNA binding; transregulation).
C/EBPalpha(h) --> PPARG(h) (DNA binding; transactivation).
C/EBPalpha(h) --/ c-Myc(h) (decrease of abundance)
C/EBPalpha(h) --/ B-Myb(h) (decrease of abundance)
C/EBPalpha(h) --/ Cdk1(h) (decrease of abundance)
C/EBPalpha(h) --/ dihydrofolate reductase(h) (decrease of abundance)
C/EBPalpha(h) + GABP-alpha(h) <==> C/EBPalpha(h):GABP-alpha(h) (binding)
C/EBPalpha(h) --> FCAR(h) (transactivation)
C/EBPalpha(h) --> MIRN223(h) (DNA binding; transactivation)
C/EBPalpha(h) --/ Cdk4(h) (decrease of abundance)
C/EBPalpha(h) --/ cyclinD1(h) (decrease of abundance)
C/EBPalpha(h) --/ cyclinA(h) (decrease of abundance)
C/EBPalpha(h) --> Cdk4(h){ub} (increase of ubiquitination)
AML1(h) + C/EBPalpha(h) <==> AML1(h):C/EBPalpha(h) (binding)
C/EBPalpha(h) + FOXO1A(m) <==> C/EBPalpha(h):FOXO1A(m) (binding)
C/EBPalpha(h) --> ADIPOQ(h) (DNA binding; transactivation).
C/EBPalpha(h) --> Adipoq(m) (DNA binding).
C/EBPalpha(h) --> IGHE(h) (DNA binding; transactivation).
C/EBPalpha(h) --> PRTN3(h) (DNA binding).
CEBPA(h) --> C/EBPalpha(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

21Phosphoserine (MAPK1;MAPK3)14701740Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr19

 Promoter: 38484660 - 38486660Agilent_014791

chr19

 Promoter: 38484660 - 38486660GoldenGate_Methylation_Cancer_Panel_I

chr19

 Promoter: 38484660 - 38486660GSE27584

chr19

 Promoter: 38484660 - 38486660PMID:16537832

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