| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1080 |
Name | CFTR |
Synonymous | ABC35|ABCC7|CF|CFTR/MRP|MRP7|TNR-CFTR|dJ760C5.1;cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7);CFTR;cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) |
Definition | cAMP-dependent chloride channel|channel conductance-controlling ATPase|cystic fibrosis transmembrane conductance regulator |
Position | 7q31.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
|
Regulation From TransFac database |
CFTR(h) + NHERF-1(m) <==> CFTR(h):NHERF-1(m) (binding) | CFTR(h) --> CFTR(h) (expression). | CFTR(h) --> CFTR(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
660 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 686 | Phosphoserine (by PKC). | Swiss-Prot 53.0 | 700 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 712 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 737 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 753 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 768 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 790 | Phosphoserine (by PKC). | Swiss-Prot 53.0 | 795 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 813 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 894 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 900 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 686 | Phosphoserine (PKC alpha;PK) | 92316961;1377674 | Phospho.ELM 6.0 | 712 | Phosphoserine | 14602047 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 116905753 - 116907753 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 116905753 - 116907753 | GSE27584 |
chr7 |
Promoter: 116905753 - 116907753 | Agilent_014791_44K |
chr7 |
Promoter: 116905753 - 116907753 | PMID:15526362 |