Entrez Gene

Basic Information
Gene ID	11315
Name	PARK7
Synonymous	DJ-1\|DJ1\|HEL-S-67p;parkinson protein 7;PARK7;parkinson protein 7
Definition	Parkinson disease (autosomal recessive, early onset) 7\|epididymis secretory sperm binding protein Li 67p\|oncogene DJ1\|protein DJ-1\|protein deglycase DJ-1
Position	1p36.23
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
DJ-1(h) + DJ-1(h) <==> DJ-1(h):DJ-1(h) (binding)
SAE2(h) + DJ-1(h) <==> SAE2(h):DJ-1(h) (binding)
sumo1(h) + DJ-1(h) <==> sumo1(h):DJ-1(h) (binding)
Ubc9(h) + DJ-1(h) <==> Ubc9(h):DJ-1(h) (binding)
Daxx(h) + DJ-1(h) <==> Daxx(h):DJ-1(h) (binding)
Daxx(h) + DJ-1(h) <==> Daxx(h):DJ-1(h) (binding)
DJ-1(h) --> TH(h) (transactivation)
DJ-1(h) --> PSF(h){sumo} (decrease of sumoylation)
DJ-1(h) --> HDAC1(h):PSF(h) (decrease of binding)
DJ-1(h) + sumo1(m.s.) --Ubc9(m.s.)--> DJ-1(h){sumoK130} (sumoylation)
DJ-1(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> DJ-1(h){sumo} (sumoylation)
2 DJ-1(h) <==> (DJ-1(h))2 (binding; oligomerization)
DJ-1(h) + ubiquitin(h) --> DJ-1(h){ub(1)} (ubiquitination)
parkin(h) + DJ-1(h) <==> parkin(h):DJ-1(h) (binding)
Hsp70(h) + DJ-1(h) <==> Hsp70(h):DJ-1(h) (binding)
PARK7(h) --> DJ-1(h) (expression).
DJ-1(h) + DJ-1(h) <==> DJ-1(h):DJ-1(h) (binding)
DJ-1(h) --> TH(h) (transactivation)
DJ-1(h) --> tyrosine 3-monooxygenase(h) (increase of abundance)
DJ-1(h) --> PSF(h){sumo} (decrease of sumoylation)
DJ-1(h) + sumo1(h) --> DJ-1(h){sumo} (sumoylation)
DJ-1(h) + sumo1(m.s.) --Ubc9(m.s.),PIAS2-alpha(m.s.)--> DJ-1(h){sumo} (sumoylation)
DJ-1(h) --> DJ-1(h) (translocation)
DJ-1(h) + Pink1(h) <==> DJ-1(h):Pink1(h) (binding)
bbs1(h) + DJ-1(h) <==> bbs1(h):DJ-1(h) (binding)
PARK7(h) --> DJ-1(h) (expression).
DJ-1(h) --> DJ-1(h) (translocation)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
67	Phosphotyrosine.		Swiss-Prot 53.0
106	Cysteine sulfinic acid (-SO2H).		Swiss-Prot 53.0
130	Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).		Swiss-Prot 53.0
67	Phosphotyrosine	15592455	Phospho.ELM 6.0