Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1387

Name

CREBBP

Synonymous

CBP|KAT3A|RSTS;CREB binding protein;CREBBP;CREB binding protein

Definition

CREB-binding protein

Position

16p13.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

beta-catenin(x) + CBP(h) <==> beta-catenin(x):CBP(h) (binding)
hipk2(h) + CBP(h) <==> hipk2(h):CBP(h) (binding)
CREB(h) + CBP(h) <==> CREB(h):CBP(h) (binding).
CBP(h) + TIF2(h) <==> CBP(h):TIF2(h) (binding).
ZAC-1b(m) + CBP(h) <==> ZAC-1b(m):CBP(h) (binding).
CBP(h) + HNF-4(h) <==> CBP(h):HNF-4(h) (binding)
PPARgamma1(h) + CBP(h) <==> PPARgamma1(h):CBP(h) (binding)
PPARdelta(h) + CBP(h) <==> PPARdelta(h):CBP(h) (binding)
CBP(h) + c-Jun(h) <==> CBP(h):c-Jun(h) (binding).
CBP(h) + RelA-p65(h) <==> CBP(h):RelA-p65(h) (binding).
CBP(h) + STAT2(h) <==> CBP(h):STAT2(h) (binding).
CBP(h) + JunB(h) <==> CBP(h):JunB(h) (binding).
PPARgamma(h) + CBP(h) <==> PPARgamma(h):CBP(h) (binding).
TRIF(h) + CBP(h) <==> TRIF(h):CBP(h) (binding)
TRAM(h) + CBP(h) <==> TRAM(h):CBP(h) (binding)
NF-AT1(h) + CBP(h) <==> NF-AT1(h):CBP(h) (assembly; binding; interaction)
IRF-3(h) + CBP(h) <==> IRF-3(h):CBP(h) (binding)
huntingtin(h) + CBP(h) <==> huntingtin(h):CBP(h) (binding)
p73alpha(mo) + CBP(h) <==> p73alpha(mo):CBP(h) (binding)
p73beta(mo) + CBP(h) <==> p73beta(mo):CBP(h) (binding)
CBP(h) + STAT5A(m){glyT92} <==> CBP(h):STAT5A(m){glyT92} (binding)
c-Ets-2(h) + CBP(h) <==> c-Ets-2(h):CBP(h) (binding)
CBP(h) --> TERT(h) (transactivation)
CBP(h) + HNF-1alpha(h) <==> CBP(h):HNF-1alpha(h) (binding)
CREBBP(h) --> CBP(h) (expression).
HNF-4(h) + acetyl-CoA --CBP(h)--> HNF-4(h){ace} + CoA (acetylation)
Sp3(h) + acetyl-CoA --CBP(h)--> Sp3(h){ace} + CoA (acetylation)
foxo4(h) + acetyl-CoA --CBP(h)--> foxo4(h){ace} + CoA (acetylation)
PARP(h) + 5 acetyl-CoA --CBP(h)--> PARP(h){aceK498}{aceK505}{aceK508}{aceK521}{aceK524} + 5 CoA (acetylation)
RSK1(h) + CBP(h) <==> RSK1(h):CBP(h) (binding)
CBP(h) + fgfr1(v.s.) <==> CBP(h):fgfr1(v.s.) (binding)
ASC-2(h) + CBP(h) <==> ASC-2(h):CBP(h) (binding)
Daxx(h) + CBP(h) + Pax-5(h) <==> Daxx(h):CBP(h):Pax-5(h) (binding)
CBP(h) + Daxx(h) <==> CBP(h):Daxx(h) (binding)
CBP(h) + c-Myc(h) <==> CBP(h):c-Myc(h) (binding)
Max(h) + CBP(h) <==> Max(h):CBP(h) (binding)
Ro52(h) + IKK-gamma(h) + IKK-beta(h) + IKK-alpha(h) + CBP(h) + TIF2(h) + SRC3(h) <==> Ro52(h):IKK-gamma(h):IKK-beta(h):IKK-alpha(h):CBP(h):TIF2(h):SRC3(h) (binding)
Ro52(h) + CBP(h) + TIF2(h) + SRC-1(h) <==> Ro52(h):CBP(h):TIF2(h):SRC-1(h) (binding)
IKK-gamma(h) + IKK-beta(h) + CBP(h) + SRC3(h) <==> IKK-gamma(h):IKK-beta(h):CBP(h):SRC3(h) (binding)
Ku70(h) + CBP(h) <==> Ku70(h):CBP(h) (binding)
CBP(h) --> CBP(h) (translocation)
CBP(h) + FOXO1A(h) <==> CBP(h):FOXO1A(h) (binding)
c-Ets-1(m){pT38} + CBP(h) <==> c-Ets-1(m){pT38}:CBP(h) (binding)
CBP(h) + c-Ets-2(m){pT72} <==> CBP(h):c-Ets-2(m){pT72} (binding)
CBP(h) + sumo1(h) --> CBP(h){sumo} (sumoylation)
CBP(h) + COE1-long(m) <==> CBP(h):COE1-long(m) (binding)
CBP(h) + HOXB6(h) <==> CBP(h):HOXB6(h) (binding)
ASC-2(h) + DRIP205(h) + p300(h) + CBP(h) + NCOA6IP(m.s.) <==> ASC-2(h):DRIP205(h):p300(h):CBP(h):NCOA6IP(m.s.) (binding)
p/CAF(h) + CBP(h) + p300(h) + E2A(h) <==> p/CAF(h):CBP(h):p300(h):E2A(h) (binding)
E2A(h) + CBP(h) <==> E2A(h):CBP(h) (binding)
CBP(h) + GCMa(h) <==> CBP(h):GCMa(h) (binding)
APC5(h) + CBP(h) <==> APC5(h):CBP(h) (binding)
CBP(h) + APC7(h) <==> CBP(h):APC7(h) (binding)
Cdc20(h) + CBP(h) <==> Cdc20(h):CBP(h) (binding)
Fzr1(h) + CBP(h) <==> Fzr1(h):CBP(h) (binding)
CBP(h) --/ cyclinB1(h) (decrease of abundance)
CBP(h) --/ plk1(h) (decrease of abundance)
Smad1(m.s.) + CBP(h) <==> Smad1(m.s.):CBP(h) (binding)
Smad2(m.s.) + CBP(h) <==> Smad2(m.s.):CBP(h) (binding)
CBP(h) + ATP --> CBP(h){p} + ADP (phosphorylation)
CBP(h) + TDG(h) <==> CBP(h):TDG(h) (binding)
CBP(h) + SET-isoform2(m.s.) <==> CBP(h):SET-isoform2(m.s.) (binding)
CBP(h) + CREB1(h) <==> CBP(h):CREB1(h) (binding)
CBP(h) + CREM(h) <==> CBP(h):CREM(h) (binding)
CBP(h) + ATF-2(h) <==> CBP(h):ATF-2(h) (binding)
CBP(h) + p300(h) <==> CBP(h):p300(h) (binding)
CBP(h) + AML1(h) <==> CBP(h):AML1(h) (binding)
RelA-p65(h) + CBP(h) <==> RelA-p65(h):CBP(h) (binding)
p53(h) + CBP(h) <==> p53(h):CBP(h) (binding)
CBP(h) + IKK-alpha(h) <==> CBP(h):IKK-alpha(h) (binding)
CBP(h) + 2 ATP --IKK-alpha(h)--> CBP(h){pS1382}{pS1386} + 2 ADP (phosphorylation)
CBP(h) --> protein remnants (degradation)
brca1(h) + CBP(h) <==> brca1(h):CBP(h) (binding)
ER-alpha(h) + CBP(h) <==> ER-alpha(h):CBP(h) (binding)
NR1B1(h) + CBP(h) <==> NR1B1(h):CBP(h) (binding)
brca1(m.s.) + CBP(h) <==> brca1(m.s.):CBP(h) (binding)
CBP(h) + ER-alpha(m.s.) <==> CBP(h):ER-alpha(m.s.) (binding)
CBP(h) + Nrf2(m) <==> CBP(h):Nrf2(m) (binding)
CBP(h) + MNAR-isoform1(h) <==> CBP(h):MNAR-isoform1(h) (binding)
CBP(h) + IRF-3(h) <==> CBP(h):IRF-3(h) (binding)
c-Jun(h) + CBP(h) <==> CBP(h):c-Jun(h) (binding)
CBP(h) + ING1(h) <==> CBP(h):ING1(h) (binding)
CBP(h) + ING1a(h) <==> CBP(h):ING1a(h) (binding)
CBP(h) + ING1b(h) <==> CBP(h):ING1b(h) (binding)
CBP(h) + IFNAR2(h) <==> CBP(h):IFNAR2(h) (binding)
AKT(h) + CBP(h) <==> AKT(h):CBP(h) (binding)
CBP(h) + RelA-p65(h) <==> CBP(h):RelA-p65(h) (binding)
MSH2(h) + CBP(h) <==> MSH2(h):CBP(h) (binding)
GTBP(h) + CBP(h) <==> GTBP(h):CBP(h) (binding)
zbtb2(h) + CBP(h) <==> zbtb2(h):CBP(h) (binding)
ZASC1(h) + CBP(h) <==> ZASC1(h):CBP(h) (binding)
CREBBP(h) --> CBP(h) (expression).
CBP(h) --> CBP(h) (translocation)
PARP(h) + acetyl-CoA --CBP(h)--> PARP(h){aceK} + CoA (acetylation)
IFNAR2-isoform1(h) + acetyl-CoA --CBP(h)--> IFNAR2-isoform1(h){aceK399} + CoA (acetylation)
IRF-9(h) + acetyl-CoA --CBP(h)--> IRF-9(h){aceK} + CoA (acetylation)
STAT2(h) + acetyl-CoA --CBP(h)--> STAT2(h){aceK} + CoA (acetylation)

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

601Omega-N-methylated arginine (Bysimilarity).Swiss-Prot 53.0
625Omega-N-methylated arginine (Bysimilarity).Swiss-Prot 53.0
1588N6-acetyllysine.Swiss-Prot 53.0
1591N6-acetyllysine.Swiss-Prot 53.0
1592N6-acetyllysine.Swiss-Prot 53.0
1595N6-acetyllysine.Swiss-Prot 53.0
1597N6-acetyllysine.Swiss-Prot 53.0
2063Phosphoserine15302935Phospho.ELM 6.0
302Phosphoserine (CaM-KIV)11970865Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr16

Promoter: 3869622 - 3871622Agilent_014791

chr16

Promoter: 3869622 - 3871622GoldenGate_Methylation_Cancer_Panel_I

chr16

Promoter: 3869622 - 3871622GoldenGate_Methylation_Cancer_Panel_I

chr16

Promoter: 3869622 - 3871622GSE27584

chr16

Promoter: 3869622 - 3871622GSE27584

chr16

Promoter: 3869622 - 3871622Agilent_014791_44K

chr16

Promoter: 3869622 - 3871622Agilent_014791


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