Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

Name

Synonymous

;;;

Definition

Position

Gene Type

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

There is no record for

Transcription Factors   [Top]

Regulation From TransFac database

ErbB2(h) + alpha-catenin1(h) <==> alpha-catenin1(h):ErbB2(h) (binding)
ErbB2(h) + beta-catenin(h) <==> beta-catenin(h):ErbB2(h) (binding)
ErbB2(h) + plakoglobin(h) <==> ErbB2(h):plakoglobin(h) (binding)
EGF(h) + ErbB2(h) <==> EGF(h):ErbB2(h) (binding)
ErbB2(h) + PI3K-C2alpha(h) <==> ErbB2(h):PI3K-C2alpha(h) (binding)
ErbB2(h) + PI3K-C2beta(h) <==> ErbB2(h):PI3K-C2beta(h) (binding)
ErbB2(h) + Jak2(h) <==> ErbB2(h):Jak2(h) (binding)
ErbB2(h) + ATP --> ErbB2(h){pY} + ADP (phosphorylation)
caveolin-1(h) + ErbB2(h) <==> caveolin-1(h):ErbB2(h) (binding)
Shc-1(h) + ErbB2(h) <==> Shc-1(h):ErbB2(h) (binding)
ErbB2(h) + ATP --> ErbB2(h){p} + ADP (phosphorylation)
ErbB2(h) + 2 ATP --> ErbB2(h){pY877}{pY1248} + 2 ADP (phosphorylation)
RanBP2(h) + ErbB2(h) <==> RanBP2(h):ErbB2(h) (binding)
alpha5-integrin(h) + ErbB2(h) <==> alpha5-integrin(h):ErbB2(h) (binding)
ErbB2(h) + Grp94(h) <==> ErbB2(h):Grp94(h) (binding)
RALT(h) + ErbB2(h) <==> RALT(h):ErbB2(h) (binding)
Vav-2(h) + Grb-2(h) + CD44(h) + ErbB2(h) <==> Vav-2(h):Grb-2(h):CD44(h):ErbB2(h) (binding)
Grb-2(m.s.) + Vav-2(h) + CD44(h) + ErbB2(h) <==> Grb-2(m.s.):Vav-2(h):CD44(h):ErbB2(h) (binding)
MUC4(m.s.) + ErbB2(h) <==> MUC4(m.s.):ErbB2(h) (binding)
ErbB3(h) + ErbB2(h) <==> ErbB3(h):ErbB2(h) (binding)
ErbB2(h) + 2 ATP --> ErbB2(h){pY1139}{pY1248} + 2 ADP (phosphorylation; automodification)
ErbB2(h) + 3 ATP --> ErbB2(h){pY877}{pY1221}{pY1248} + 3 ADP (phosphorylation)
alpha6-integrin(h) + ErbB2(h) <==> alpha6-integrin(h):ErbB2(h) (binding)
beta4-integrin(h) + ErbB2(h) <==> beta4-integrin(h):ErbB2(h) (binding)
gp130(h) + ErbB2(h) <==> gp130(h):ErbB2(h) (binding)
ErbB2(h) + OSMRbeta(h) <==> ErbB2(h):OSMRbeta(h) (binding)
ErbB2(h) --> protein remnants (degradation)
ErbB2(h) + 12 ATP --> ErbB2(h){pY877}{pS1049}{pS1050}{pS1051}{pS1054}{pT1060}{pS1078}{pS1083}{pS1107}{pT1166}{pS1174}{pY1248} + 12 ADP (phosphorylation)
ErbB2(h) + 16 ATP --> ErbB2(h){pY877}{pS998}{pY1005}{pS1049}{pS1050}{pS1051}{pS1054}{pT1060}{pS1066}{pS1078}{pS1083}{pS1107}{pT1166}{pT1172}{pS1174}{pY1248} + 16 ADP (phosphorylation)
ErbB2(h) + Cdk1(h) <==> Cdk1(h):ErbB2(h) (binding)
ErbB2(h) + cyclinB1(h):Cdk1(h) <==> ErbB2(h):cyclinB1(h):Cdk1(h) (binding)
ErbB2(h) + actin(h) + p65PAK(h) <==> ErbB2(h):actin(h):p65PAK(h) (binding)
ErbB2(h) + ATP --> ErbB2(h){pY1221} + ADP (phosphorylation)
ErbB2(h) + muc1(h) <==> ErbB2(h):muc1(h) (binding)
ErbB2(h) + ATP --> ErbB2(h){pY1248} + ADP (phosphorylation)
ErbB1(h) + ErbB2(h) <==> ErbB1(h):ErbB2(h) (binding)
ErbB2(h) + ErbB2(h){pY1248} <==> ErbB2(h):ErbB2(h){pY1248} (binding)
ErbB2(h) + ubiquitin(h) --> ErbB2(h){ub} (ubiquitination)
ErbB2(h) + CHIP(h) <==> ErbB2(h):CHIP(h) (binding)
ErbB1(h) + ErbB2(h) + CD44(h) <==> ErbB1(h):ErbB2(h):CD44(h) (binding)
Pyk2(h) + ErbB2(h) <==> Pyk2(h):ErbB2(h) (binding)
ErbB2(h) + ErbB4(h) <==> ErbB2(h):ErbB4(h) (binding)
ErbB2(h) + p85alpha(h) <==> ErbB2(h):p85alpha(h) (binding)
ErbB2(h) + 4 ATP --> ErbB2(h){pY1139}{pY1221}{pY1222}{p1248} + 4 ADP (phosphorylation)
ErbB2(h) + ATP --> ErbB2(h){pY1139} + ADP (phosphorylation)
E-cadherin-ECD(h) + ErbB3(h) + ErbB2(h) <==> E-cadherin-ECD(h):ErbB3(h):ErbB2(h) (binding)
E-cadherin-ECD(h) + ErbB2(h) <==> E-cadherin-ECD(h):ErbB2(h) (binding)
nucleolin(h) + ErbB2(h) <==> nucleolin(h):ErbB2(h) (binding)
ErbB2(h) + 2 ATP --> ErbB2(h){pY1221}{pY1222} + 2 ADP (phosphorylation)
ErbB2(h) + ATP --> ErbB2(h){pY877} + ADP (phosphorylation; automodification)
ErbB2(h) --> ErbB2(h){pY877} (increase of phosphorylation)
ErbB2(h) --> LMW-PTP(m){p} (increase of phosphorylation)
ErbB2(h) --> beta-actin(m){p} (decrease of phosphorylation)
ErbB2(h) --> ACTC(m){p} (decrease of phosphorylation)
ErbB2(h) --> gamma-actin(m){p} (decrease of phosphorylation)
ErbB2(h) --> AC7(m){p} (increase of phosphorylation)
ErbB2(h) --> adenylate kinase isoenzyme 1(m){p} (decrease of phosphorylation)
ErbB2(h) --> fructose-bisphosphate aldolase A(m){p} (increase of phosphorylation)
ErbB2(h) --> Ant1(m){p} (increase of phosphorylation)
ErbB2(h) --> Ant2(m){p} (increase of phosphorylation)
ErbB2(h) --> Annexin-A5(m){p} (increase of phosphorylation)
ErbB2(h) --> arnt2(m){p} (increase of phosphorylation)
ErbB2(h) --> ATP synthase subunit alpha, mitochondrial(m){p} (increase of phosphorylation)
ErbB2(h) --> annexin-A2(m){p} (increase of phosphorylation)
ErbB2(h) --> Calpain-6(m){p} (increase of phosphorylation)
ErbB2(h) --> CAPPA1(m){p} (decrease of phosphorylation)
ErbB2(h) --> CAPPA2(m){p} (decrease of phosphorylation)
ErbB2(h) --> p120CAS(m){p} (increase of phosphorylation)
ErbB2(h) --> caveolin-1(m){p} (decrease of phosphorylation)
ErbB2(h) --> PEBP2beta(m){p} (increase of phosphorylation)
ErbB2(h) --> Colligin(m){p} (increase of phosphorylation)
ErbB2(h) --> TCP-1beta(m){p} (increase of phosphorylation)
ErbB2(h) --> Cctg(m){p} (increase of phosphorylation)
ErbB2(h) --> Calponin-2(m){p} (increase of phosphorylation)
ErbB2(h) --> crabp1(m){p} (increase of phosphorylation)
ErbB2(h) --> Cas(m){p} (decrease of phosphorylation)
ErbB2(h) --> cathepsinB(m){p} (increase of phosphorylation)
ErbB2(h) --> cortactin(m){p} (increase of phosphorylation)
ErbB2(h) --> CTP(m){p} (increase of phosphorylation)
ErbB2(h) --> Dynein-1(m){p} (increase of phosphorylation)
ErbB2(h) --> p62Dok-1(m){p} (increase of phosphorylation)
ErbB2(h) --> MPDS(m){p} (increase of phosphorylation)
ErbB2(h) --> EEF1A(m){p} (increase of phosphorylation)
ErbB2(h) --> EF-2(m){p} (increase of phosphorylation)
ErbB2(h) --> Past1(m){p} (increase of phosphorylation)
ErbB2(h) --> EDMD(m){p} (increase of phosphorylation)
ErbB2(h) --> FAK1(m){p} (decrease of phosphorylation)
ErbB2(h) --> FLIL(m){p} (increase of phosphorylation)
ErbB2(h) --> flotillin-1(m){p} (decrease of phosphorylation)
ErbB2(h) --> flotillin-2(m){p} (decrease of phosphorylation)
ErbB2(h) --> fibronectin(m){p} (decrease of phosphorylation)
ErbB2(h) --> Fyn(m){p} (increase of phosphorylation)
ErbB2(h) --> Gas1(m){p} (decrease of phosphorylation)
ErbB2(h) --> glucosamine-fructose-6-phosphate aminotransferase (isomerizing) 1(m){p} (increase of phosphorylation)
ErbB2(h) --> gng12(m){p} (decrease of phosphorylation)
ErbB2(h) --> gpc1(m){p} (increase of phosphorylation)
ErbB2(h) --> Glypican-4(m){p} (decrease of phosphorylation)
ErbB2(h) --> GSTP1-1(m){p} (increase of phosphorylation)
ErbB2(h) --> hist2h2aa3(m){p} (decrease of phosphorylation)
ErbB2(h) --> HMGI-C(m){p} (increase of phosphorylation)
ErbB2(h) --> Hsc70(m){p} (increase of phosphorylation)
ErbB2(h) --> Hsp60(m){p} (increase of phosphorylation)
ErbB2(h) --> Hsp90-beta(m){p} (increase of phosphorylation)
ErbB2(h) --> Hsp90-alpha(m){p} (increase of phosphorylation)
ErbB2(h) --> Intersectin1(m){p} (decrease of phosphorylation)
ErbB2(h) --> TRIP-5(m){p} (decrease of phosphorylation)
ErbB2(h) --> kifc3(m){p} (increase of phosphorylation)
ErbB2(h) --> aminopeptidase N(m){p} (increase of phosphorylation)
ErbB2(h) --> Galectin3(m){p} (increase of phosphorylation)
ErbB2(h) --> rps2(m){p} (increase of phosphorylation)
ErbB2(h) --> Lamin B1(m){p} (decrease of phosphorylation)
ErbB2(h) --> Rrg(m){p} (decrease of phosphorylation)
ErbB2(h) --> mcm7(m){p} (decrease of phosphorylation)
ErbB2(h) --> moesin(m){p} (increase of phosphorylation)
ErbB2(h) --> CoxII(m){p} (increase of phosphorylation)
ErbB2(h) --> Myosin-9(m){p} (decrease of phosphorylation)
ErbB2(h) --> Myo1c(m){p} (decrease of phosphorylation)
ErbB2(h) --> Myosin-7A(m){p} (increase of phosphorylation)
ErbB2(h) --> MYPT1(m){p} (increase of phosphorylation)
ErbB2(h) --> Bpx(m){p} (decrease of phosphorylation)
ErbB2(h) --> NEDD4-1(m){p} (increase of phosphorylation)
ErbB2(h) --> nrap(m){p} (decrease of phosphorylation)
ErbB2(h) --> Otogelin(m){p} (increase of phosphorylation)
ErbB2(h) --> PabpC1(m){p} (increase of phosphorylation)
ErbB2(h) --> Paralemmin(m){p} (increase of phosphorylation)
ErbB2(h) --> PIMT(m){p} (increase of phosphorylation)
ErbB2(h) --> Alg-2(m){p} (increase of phosphorylation)
ErbB2(h) --> phosphoglycerate mutase 1(m){p} (increase of phosphorylation)
ErbB2(h) --> phosphoglycerate kinase 1(m){p} (increase of phosphorylation)
ErbB2(h) --> p85alpha(m){p} (increase of phosphorylation)
ErbB2(h) --> p85beta(m){p} (increase of phosphorylation)
ErbB2(h) --> pyruvate kinase isozyme M2(m){p} (increase of phosphorylation)
ErbB2(h) --> PLCgamma1(m){p} (increase of phosphorylation)
ErbB2(h) --> plectin(m){p} (increase of phosphorylation)
ErbB2(h) --> ppef2(m){p} (increase of phosphorylation)
ErbB2(h) --> Cypc(m){p} (increase of phosphorylation)
ErbB2(h) --> Lmp19(m){p} (increase of phosphorylation)
ErbB2(h) --> S7(m){p} (increase of phosphorylation)
ErbB2(h) --> prostaglandin G/H synthase 1(m){p} (increase of phosphorylation)
ErbB2(h) --> rab18(m){p} (increase of phosphorylation)
ErbB2(h) --> Rab7(m){p} (increase of phosphorylation)
ErbB2(h) --> Rac1(m){p} (increase of phosphorylation)
ErbB2(h) --> rps12(m){p} (increase of phosphorylation)
ErbB2(h) --> rps14(m){p} (increase of phosphorylation)
ErbB2(h) --> RPS16(m){p} (increase of phosphorylation)
ErbB2(h) --> Rps4(m){p} (increase of phosphorylation)
ErbB2(h) --> R-Ras(m){p} (increase of phosphorylation)
ErbB2(h) --> Rsu-1(m){p} (decrease of phosphorylation)
ErbB2(h) --> SERS(m){p} (increase of phosphorylation)
ErbB2(h) --> Semk1(m){p} (increase of phosphorylation)
ErbB2(h) --> Intersectin2(m){p} (decrease of phosphorylation)
ErbB2(h) --> GLUT1(m){p} (increase of phosphorylation)
ErbB2(h) --> COD(m){p} (increase of phosphorylation)
ErbB2(h) --> alpha-fodrin(m){p} (decrease of phosphorylation)
ErbB2(h) --> beta2-spectrin(m){p} (decrease of phosphorylation)
ErbB2(h) --> APMCF1(m){p} (increase of phosphorylation)
ErbB2(h) --> TRAPD(m){p} (increase of phosphorylation)
ErbB2(h) --> STAT1(m){p} (increase of phosphorylation)
ErbB2(h) --> ERV29(m){p} (increase of phosphorylation)
ErbB2(h) --> transgelin-2(m){p} (increase of phosphorylation)
ErbB2(h) --> TCP1alpha(m){p} (increase of phosphorylation)
ErbB2(h) --> CD90(m){p} (decrease of phosphorylation)
ErbB2(h) --> triosephosphate isomerase(m){p} (increase of phosphorylation)
ErbB2(h) --> Tpm-1(m){p} (decrease of phosphorylation)
ErbB2(h) --> TPM-2(m){p} (decrease of phosphorylation)
ErbB2(h) --> Grp94(m){p} (increase of phosphorylation)
ErbB2(h) --> TTN(m){p} (increase of phosphorylation)
ErbB2(h) --> alpha-tubulin 1B(m){p} (increase of phosphorylation)
ErbB2(h) --> alpha-tubulin 6(m){p} (increase of phosphorylation)
ErbB2(h) --> Beta-tubulin3(m){p} (increase of phosphorylation)
ErbB2(h) --> Beta-tubulin(m){p} (increase of phosphorylation)
ErbB2(h) --> utrophin(m){p} (decrease of phosphorylation)
ErbB2(h) --> ezrin(m){p} (increase of phosphorylation)
ErbB2(h) --> Vimentin(m){p} (increase of phosphorylation)
ErbB2(h) --> 14-3-3epsilon(m){p} (increase of phosphorylation)
ErbB2(h) --> 14-3-3gamma(m){p} (increase of phosphorylation)
ErbB2(h) --> 14-3-3tau(m){p} (increase of phosphorylation)
ErbB2(h) --> 14-3-3zeta(m){p} (increase of phosphorylation)
ErbB2(h) --> Coronin-3(m){p} (increase of phosphorylation)
ErbB2(h) --> SLAP-130(m){p} (increase of phosphorylation)
ErbB2(h) --> RKIP(m){p} (increase of phosphorylation)
ErbB2(h) --> Axl(m){p} (increase of phosphorylation)
ErbB2(h) --> p202(m){p} (increase of phosphorylation)
ErbB2(h) --> MKK4(m){p} (decrease of phosphorylation)
ErbB2(h) --> procollagen-lysine,2-oxoglutarate 5-dioxygenase 3(m){p} (increase of phosphorylation)
ErbB2(h) --> psmb2(m){p} (increase of phosphorylation)
ErbB2(h) --> CRMP3(m){p} (decrease of phosphorylation)
ErbB2(h) --> RPS3(m){p} (increase of phosphorylation)
ErbB2(h) --> sec23B(m){p} (decrease of phosphorylation)
ErbB2(h) --> rps11(m){p} (increase of phosphorylation)
ErbB2(h) --> abcf2(m){p} (increase of phosphorylation)
ErbB2(h) --> G7c(m){p} (decrease of phosphorylation)
ErbB2(h) --> Sws1(m){p} (increase of phosphorylation)
ErbB2(h) --> limd1(m){p} (increase of phosphorylation)
ErbB2(h) --> VAP33(m){p} (increase of phosphorylation)
ErbB2(h) --> MRP-S7(m){p} (increase of phosphorylation)
ErbB2(h) --> Aralar2(m){p} (increase of phosphorylation)
ErbB2(h) --> CTP synthase 1(m){p} (increase of phosphorylation)
ErbB2(h) --> SAF-A(m){p} (decrease of phosphorylation)
ErbB2(h) --> commd2(m){p} (increase of phosphorylation)
ErbB2(h) --> CDP-diacylglycerol-inositol 3-phosphatidyltransferase(m){p} (increase of phosphorylation)
ErbB2(h) --> hnrnpa2b1(m){p} (decrease of phosphorylation)
ErbB2(h) --> SEC61A(m){p} (increase of phosphorylation)
ErbB2(h) --> Tim23(m){p} (increase of phosphorylation)
ErbB2(h) --> Golgin-245(m){p} (decrease of phosphorylation)
ErbB2(h) --> Prap(m){p} (increase of phosphorylation)
ErbB2(h) --> 14-3-3beta(m){p} (increase of phosphorylation)
ErbB2(h) --> Rw1(m){p} (increase of phosphorylation)
ErbB2(h) --> drebrin(m){p} (decrease of phosphorylation)
ErbB2(h) --> estradiol 17-beta-dehydrogenase 12(m){p} (increase of phosphorylation)
ErbB2(h) --> P22(m){p} (increase of phosphorylation)
ErbB2(h) --> hnRNP-Q(m){p} (increase of phosphorylation)
ErbB2(h) --> VAPB(m){p} (increase of phosphorylation)
ErbB2(h) --> NIR(m){p} (increase of phosphorylation)
ErbB2(h) --> TACC2(m){p} (decrease of phosphorylation)
ErbB2(h) --> rpl23(m){p} (increase of phosphorylation)
ErbB2(h) --> Eplin(m){p} (decrease of phosphorylation)
ErbB2(h) --> LRRK2(m){p} (increase of phosphorylation)
ErbB2(h) --> JPDI(m){p} (increase of phosphorylation)
ErbB2(h) --> mtap(m){p} (increase of phosphorylation)
ErbB2(h) --> succinate dehydrogenase (ubiquinone) flavoprotein subunit(m){p} (increase of phosphorylation)
ErbB2(h) --> S5(m){p} (decrease of phosphorylation)
ErbB2(h) --> rpl11(m){p} (increase of phosphorylation)
ErbB2(h) --> RPS10(m){p} (increase of phosphorylation)
ErbB2(h) --> prostaglandin reductase 1(m){p} (increase of phosphorylation)
ErbB2(h) --> EF1G(m){p} (increase of phosphorylation)
ErbB2(h) --> GIE1(m){p} (increase of phosphorylation)
ErbB2(h) --> rpl38(m){p} (increase of phosphorylation)
ErbB2(h) --> slc25a11(m){p} (increase of phosphorylation)
ErbB2(h) --> DB83(m){p} (increase of phosphorylation)
ErbB2(h) --> rps27l(m){p} (increase of phosphorylation)
ErbB2(h) --> beta-tubulin 6(m){p} (increase of phosphorylation)
ErbB2(h) --> Cntd(m){p} (increase of phosphorylation)
ErbB2(h) --> nexilin(m){p} (decrease of phosphorylation)
ErbB2(h) --> AsnRS(m){p} (increase of phosphorylation)
ErbB2(h) --> AFAP(m){p} (increase of phosphorylation)
ErbB2(h) --> taf15(m){p} (decrease of phosphorylation)
ErbB2(h) --> NUP205(m){p} (decrease of phosphorylation)
ErbB2(h) --> DG6(m){p} (increase of phosphorylation)
ErbB2(h) --> rnf36(m){p} (increase of phosphorylation)
ErbB2(h) --> lrrfip2(m){p} (increase of phosphorylation)
ErbB2(h) --> Tip120a(m){p} (increase of phosphorylation)
ErbB2(h) --> rap2c(m){p} (increase of phosphorylation)
ErbB2(h) --> top1mt(m){p} (decrease of phosphorylation)
ErbB2(h) --> Sfec(m){p} (increase of phosphorylation)
ErbB2(h) --> Necc2(m){p} (increase of phosphorylation)
ErbB2(h) --> Drp1(m){p} (decrease of phosphorylation)
ErbB2(h) --> HNRNPR(m){p} (increase of phosphorylation)
ErbB2(h) --> p110beta(m){p} (increase of phosphorylation)
ErbB2(h) --> NADH dehydrogenase (ubiquinone) iron-sulfur protein 7, mitochondrial(m){p} (decrease of phosphorylation)
ErbB2(h) --> CUL-5(m){p} (increase of phosphorylation)
ErbB2(h) --> rab35(m){p} (increase of phosphorylation)
ErbB2(h) --> zc3hav1(m){p} (increase of phosphorylation)
ErbB2(h) --> ARALAR1(m){p} (increase of phosphorylation)
ErbB2(h) --> hist2h4(m){p} (decrease of phosphorylation)
ErbB2(h) --> trifunctional enzyme subunit alpha, mitochondrial(m){p} (increase of phosphorylation)
ErbB2(h) --> numa1(m){p} (increase of phosphorylation)
ErbB2(h) --> ddx1(m){p} (increase of phosphorylation)
ErbB2(h) --> TRAPA(m){p} (increase of phosphorylation)
ErbB2(h) --> shmt2(m){p} (increase of phosphorylation)
ErbB2(h) --> CDM(m){p} (decrease of phosphorylation)
ErbB2(h) --> Rap1A(m){p} (increase of phosphorylation)
ErbB2(h) --> farnesyl pyrophosphate synthetase(m){p} (increase of phosphorylation)
ErbB2(h) --> rpl10(m){p} (increase of phosphorylation)
ErbB2(h) --> IMP-1(m){p} (decrease of phosphorylation)
ErbB2(h) --> VICKZ3(m){p} (decrease of phosphorylation)
ErbB2(h) --> Hook2(m){p} (decrease of phosphorylation)
ErbB2(h) --> ABP-280(m){p} (decrease of phosphorylation)
ErbB2(h) --> RhoGDI-1(m){p} (increase of phosphorylation)
ErbB2(h) --> ZIZ3(m){p} (increase of phosphorylation)
ErbB2(h) --> ALL1(m){p} (decrease of phosphorylation)
ErbB2(h) --> L22mt(m){p} (increase of phosphorylation)
ErbB2(h) --> RasGAP(m){p} (increase of phosphorylation)
ErbB2(h) --> wdsof1(m){p} (decrease of phosphorylation)
ErbB2(h) --> EPIPL(m){p} (increase of phosphorylation)
ErbB2(h) --> RIN1(m){p} (increase of phosphorylation)
ErbB2(h) --> PRC(m){p} (increase of phosphorylation)
ErbB2(h) --> importin9(m){p} (decrease of phosphorylation)
ErbB2(h) --> Beta-Tubulin2C(m){p} (increase of phosphorylation)
ErbB2(h) --> SNAP190(m){p} (decrease of phosphorylation)
ErbB2(h) --> Fgs(m){p} (increase of phosphorylation)
ErbB2(h) --> daglb(m){p} (decrease of phosphorylation)
ErbB2(h) --> importin-7(m){p} (increase of phosphorylation)
ErbB2(h) --> TLS(m){p} (decrease of phosphorylation)
ErbB2(h) --> AlaRS(m){p} (increase of phosphorylation)
ErbB2(h) --> CPAMD7(m){p} (decrease of phosphorylation)
ErbB2(h) --> alms1(m){p} (increase of phosphorylation)
ErbB2(h) --> D-3-phosphoglycerate dehydrogenase(m){p} (increase of phosphorylation)
ErbB2(h) --> tmtc3(m){p} (decrease of phosphorylation)
ErbB2(h) --> Kappa-actin(m){p} (decrease of phosphorylation)
ErbB2(h) --> NFBD1(m){p} (increase of phosphorylation)
ErbB2(h) --> lrrc52(m){p} (increase of phosphorylation)
ErbB2(h) --> fsip2(m){p} (decrease of phosphorylation)
ErbB2(h) --> Paralemmin2(m){p} (increase of phosphorylation)
ErbB2(h) --> rps15a(m){p} (increase of phosphorylation)
ErbB2(h) --> ahsa2(m){p} (increase of phosphorylation)
ErbB2(h) --> cpsf7(m){p} (decrease of phosphorylation)
ErbB2(h) --> neurofascin(m){p} (increase of phosphorylation)
ErbB2(h) --> vcp(m){p} (increase of phosphorylation)
ErbB2(h) --> Gm187(m){p} (decrease of phosphorylation)
ErbB2(h) --> Tpm-4(m){p} (increase of phosphorylation)
ErbB2(h) --> MCC1(m){p} (increase of phosphorylation)
ErbB2(h) --> Keratin78(m){p} (decrease of phosphorylation)
ErbB2(h) --> myr4(m){p} (decrease of phosphorylation)
ErbB2(h) --> Gapr1(m){p} (decrease of phosphorylation)
ErbB2(h) --> uridine 5'-monophosphate synthase(m){p} (increase of phosphorylation)
ErbB2(h) --> Filamin-C(m){p} (decrease of phosphorylation)
ErbB2(h) --> WDR9(m){p} (decrease of phosphorylation)
ErbB2(h) --> Cmya3(m){p} (decrease of phosphorylation)
ErbB2(h) --> auts2(m){p} (decrease of phosphorylation)
ErbB2(h) + p85(h) <==> ErbB2(h):p85(h) (binding)
ErbB2(h) + Plexin-B1(m.s.) <==> ErbB2(h):Plexin-B1(m.s.) (binding)
ErbB2(h) + Plexin-B1(h) <==> ErbB2(h):Plexin-B1(h) (binding)
DP97(h) --> ErbB2(h) (increase of abundance)
estradiol --/ ErbB2(h) (decrease of abundance)
EGF(m.s.) --> ErbB2(h) (increase of abundance)
CHIP(h) --/ ErbB2(h) (decrease of abundance)
ERBB2(h) --> ErbB2(h) (expression).
YB-1(m.s.) --> ErbB2(h) (increase of abundance)
YB-1(h) --> ErbB2(h) (increase of abundance)
FOXP3(h) --/ ErbB2(h) (decrease of abundance)
IFNgamma(m.s.) --/ ErbB2(h) (decrease of abundance)
RIG1(m.s.) --/ ErbB2(h) (decrease of abundance)
Cdk1(m.s.) + ATP --ErbB2(h)--> Cdk1(m.s.){pY15} + ADP (phosphorylation)
ErbB2(h) + ATP --> ErbB2(h){pY} + ADP (phosphorylation; automodification)
ErbB2(h) + ErbB1-p170(h) <==> ErbB2(h):ErbB1-p170(h) (binding)
ErbB2(h) + alpha5-integrin(h) <==> ErbB2(h):alpha5-integrin(h) (binding)
ErbB2(h) + ATP --> ErbB2(h){pY1248} + ADP (phosphorylation; automodification)
ErbB2(h) + ErbB1(h) <==> ErbB1(h):ErbB2(h) (binding)
ErbB2(h) + ATP --> ErbB2(h){pT686} + ADP (phosphorylation)
ErbB2(h) + ATP --> ErbB2(h){pY1222} + ADP (phosphorylation; automodification)
ErbB2(h) + 3 ATP --> ErbB2(h){pY877}{pY1112}{pY1248} + 3 ADP (phosphorylation)
LRIG1-xbb1(h) + ErbB2(h) <==> LRIG1-xbb1(h):ErbB2(h) (binding)
ErbB2(h) + n ubiquitin(h) --> ErbB2(h){ub(n)} (ubiquitination)
ErbB2(h) + fer(h) <==> ErbB2(h):fer(h) (binding)
ErbB2(h) + Fes(h) <==> ErbB2(h):Fes(h) (binding)
ErbB2(h) + CHK(h) <==> ErbB2(h):CHK(h) (binding)
ErbB2(h) + PTK6(h) <==> ErbB2(h):PTK6(h) (binding)
ErbB2(h) + Shb(h) <==> ErbB2(h):Shb(h) (binding)
ErbB2(h) + ZAP-70-isoform1(h) <==> ErbB2(h):ZAP-70-isoform1(h) (binding)
ErbB2(h) + ATP --Src(h)--> ErbB2(h){p} + ADP (phosphorylation)
ErbB2(h) + 2 ATP --> ErbB2(h){pS}{pT} + 2 ADP (phosphorylation)
ErbB2(h) + 7 ATP --ErbB1-p170(h)--> ErbB2(h){pY1023}{pY1127}{pY1139}{pY1196}{pY1221}{pY1222}{pY1248} + 7 ADP (phosphorylation)
ErbB2(h) + ubiquitin(h) --> ErbB2(h){ub} (ubiquitination)
ErbB2(h) --> protein remnants (degradation)
ErbB2(h) + ubiquitin(h) --CHIP(h)--> ErbB2(h){ub} (ubiquitination)
CHIP(h) + ErbB2(h) <==> CHIP(h):ErbB2(h) (binding)
Hsp70-1(h) + ErbB2(h) <==> Hsp70-1(h):ErbB2(h) (binding)
ErbB3-isoform1(h) + ErbB2(h) <==> ErbB3-isoform1(h):ErbB2(h) (binding)
ErbB4(h) + ErbB2(h) <==> ErbB4(h):ErbB2(h) (binding)
ErbB2(h) + ATP --ErbB4(h)--> ErbB2(h){pY} + ADP (phosphorylation)
ErbB2(h) + HPRG(m.s.) <==> ErbB2(h):HPRG(m.s.) (binding)
ErbB2(h) + ATP --> ErbB2(h){pY1248} + ADP (phosphorylation)
Plexin-B1(h) + ErbB2(h) <==> Plexin-B1(h):ErbB2(h) (binding)
ErbB2(h) + ATP --> ErbB2(h){pY877} + ADP (phosphorylation; automodification)
ERBB2(h) --> ErbB2(h) (expression).
cyclinB1(h):Cdk1(h) + ATP --ErbB2(h)--> cyclinB1(h):Cdk1(h){pY15} + ADP (phosphorylation)
ErbB3-isoform1(h) + ATP --ErbB2(h)--> ErbB3-isoform1(h){pY} + ADP (phosphorylation)
ErbB4(h) + ATP --ErbB2(h)--> ErbB4(h){pY} + ADP (phosphorylation)
ERBB2(h) --> ErbB2(h) (expression).
hsa-miR-125b --/ ErbB2(h) (increase of mRNA decay).
hsa-miR-125a --/ ErbB2(h) (increase of mRNA decay).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

68N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
124N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
187N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
259N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
530N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
571N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
629N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1139Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1196Phosphotyrosine (Potential).Swiss-Prot 53.0
1248Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1139Phosphotyrosine (ErbB2)11500516Phospho.ELM 6.0
1196Phosphotyrosine (ErbB2)11500516Phospho.ELM 6.0
1221Phosphotyrosine (ErbB2)11500516Phospho.ELM 6.0
1222Phosphotyrosine (ErbB2)11500516Phospho.ELM 6.0
1248Phosphotyrosine (ErbB2)11500516;17081983Phospho.ELM 6.0
686PhosphothreonineN.N.Phospho.ELM 6.0
1172Phosphothreonine (CaM-KIIalpha)8700533Phospho.ELM 6.0
1112Phosphotyrosine10910043Phospho.ELM 6.0
877Phosphotyrosine15695410Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr17

Promoter: 35096419 - 35098419GoldenGate_Methylation_Cancer_Panel_I

chr17

Promoter: 35096419 - 35098419GSE27584

chr17

Promoter: 35108280 - 35110280GSE27584

chr17

Promoter: 35108280 - 35110280Agilent_014791_44K


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