Entrez Gene

Basic Information
Gene ID	23239
Name	PHLPP1
Synonymous	PHLPP\|PLEKHE1\|SCOP;PH domain and leucine rich repeat protein phosphatase 1;PHLPP1;PH domain and leucine rich repeat protein phosphatase 1
Definition	PH domain leucine-rich repeat-containing protein phosphatase 1\|PH domain-containing family E member 1\|SCN circadian oscillatory protein\|pleckstrin homology domain containing, family E (with leucine rich repeats) member 1\|suprachiasmatic nucleus circadian
Position	18q21.33
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
phlpp1(h) + PKCbetaII(m.s.) <==> phlpp1(h):PKCbetaII(m.s.) (binding)
PHLPP(h) --> phlpp1(h) (expression).
PKCbetaII(m.s.){pT641}{pS660} --phlpp1(h)--> PKCbetaII(m.s.) + 2 p (dephosphorylation)
PKCbetaII(m.s.){p} --phlpp1(h)--> PKCbetaII(m.s.) + p (dephosphorylation)
phlpp1(h) --> AKT-2(h){pS474} (increase of phosphorylation)
phlpp1(h) --> AKT-3(h){p} (increase of phosphorylation)
phlpp1(h) --/ PKCbeta(h) (decrease of abundance)
phlpp1(h) --/ PKCalpha(h) (decrease of abundance)
phlpp1(h) --/ PKCdelta(h) (decrease of abundance)
phlpp1(h) --/ PKCepsilon(h) (decrease of abundance)
PHLPP(h) --> phlpp1(h) (expression).
Abl(h) --/ phlpp1(h) (decrease of abundance)

Post Transcriptional Modification [Top]
	There is no record for PHLPP1