Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

27250

Name

PDCD4

Synonymous

H731;programmed cell death 4 (neoplastic transformation inhibitor);PDCD4;programmed cell death 4 (neoplastic transformation inhibitor)

Definition

neoplastic transformation inhibitor protein|nuclear antigen H731|programmed cell death protein 4|protein 197/15a

Position

10q24

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Pdcd4(h) --> PDCD4(h) (expression).
hsa-miR-21 --/ PDCD4(h) (translational repression).
Pdcd4(h) --> H731(h) (expression).
EIF4A2(h) + H731(h) <==> EIF4A2(h):H731(h) (binding)
eIF-4AI(h) + H731(h) <==> eIF-4AI(h):H731(h) (binding)
Pdcd4(h) --> H731(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

76Phosphoserine.Swiss-Prot 53.0
93Phosphothreonine.Swiss-Prot 53.0
152Phosphotyrosine.Swiss-Prot 53.0
457Phosphoserine.Swiss-Prot 53.0
76Phosphoserine17081983Phospho.ELM 6.0
94Phosphoserine17081983Phospho.ELM 6.0
405Phosphotyrosine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr10

Promoter: 112620086 - 112622086Agilent_014791

chr10

Promoter: 112620086 - 112622086GSE27584

chr10

Promoter: 112620086 - 112622086GSE27584

chr10

Promoter: 112620086 - 112622086Agilent_014791_44K


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