Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2972

Name

BRF1

Synonymous

BRF|BRF-1|CFDS|GTF3B|HEL-S-76p|TAF3B2|TAF3C|TAFIII90|TF3B90|TFIIIB90|hBRF;BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit;BRF1;BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit

Definition

B - related factor 1|BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB|TATA box binding protein (TBP)-associated factor 3C|TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2|TBP - associate

Position

14q

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

TF3C-gamma-L(h) + BRF-1(h) <==> TF3C-gamma-L(h):BRF-1(h) (binding)
TF3C-epsilon(h) + BRF-1(h) <==> TF3C-epsilon(h):BRF-1(h) (binding)
TF3C-gamma-L(h) + TBP(m.s.) + TF3C-epsilon(h) + BRF-1(h) <==> TF3C-gamma-L(h):TBP(m.s.):TF3C-epsilon(h):BRF-1(h) (binding)
TF3C-epsilon(h):TF3C-alpha(h):TF3C-beta(h):TF3C-delta(h):TF3C-gamma(h) + BRF-1(h) <==> TF3C-epsilon(h):TF3C-alpha(h):TF3C-beta(h):TF3C-delta(h):TF3C-gamma(h):BRF-1(h) (binding)
POLR3C(h) + BRF-1(h) <==> POLR3C(h):BRF-1(h) (binding)
BRF-1(h) + POLR3D(h) <==> BRF-1(h):POLR3D(h) (binding)
POLR3F-xbb2(h) + BRF-1(h) <==> POLR3F-xbb2(h):BRF-1(h) (binding)
BRF1(h) --> BRF-1(h) (expression).
BRF1(h) --> BRF-1-isoform1(h) (expression).
BRF1(h) --> BRF-1-isoform2(h) (expression).
BRF1(h) --> BRF-1-isoform3(h) (expression).
BRF1(h) --> BRF-1-isoform4(h) (expression).
BRF1(h) --> BRF-1-isoform5(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

433Phosphoserine (By similarity).Swiss-Prot 53.0
553Phosphoserine.Swiss-Prot 53.0
553Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr14

Promoter: 104837874 - 104839874Agilent_014791

chr14

Promoter: 104784767 - 104786767Agilent_014791

chr14

Promoter: 104837874 - 104839874GSE27584

chr14

Promoter: 104784767 - 104786767GSE27584

chr14

Promoter: 104837874 - 104839874Agilent_014791_44K

chr14

Promoter: 104784767 - 104786767Agilent_014791_44K


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