| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3090 |
Name | HIC1 |
Synonymous | ZBTB29|ZNF901|hic-1;hypermethylated in cancer 1;HIC1;hypermethylated in cancer 1 |
Definition | hypermethylated in cancer 1 protein|zinc finger and BTB domain-containing protein 29 |
Position | 17p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
|
Regulation From TransFac database |
HIC-1-isoform2(h) + TCF-4-isoform8(h) <==> HIC-1-isoform2(h):TCF-4-isoform8(h) (binding) | CtBP1(h) + HIC-1-isoform2(h) <==> CtBP1(h):HIC-1-isoform2(h) (binding) | CtBP2(h) + HIC-1-isoform2(h) <==> CtBP2(h):HIC-1-isoform2(h) (binding) | MTA-1long(h) + HIC-1-isoform2(h) <==> MTA-1long(h):HIC-1-isoform2(h) (binding) | HIC-1-isoform2(h) + MTA-1(m.s.) <==> HIC-1-isoform2(h):MTA-1(m.s.) (binding) | HIC-1-isoform2(h) + MTA-1(h) + mbd3(h) + Mi2-alpha(h) <==> HIC-1-isoform2(h):MTA-1(h):mbd3(h):Mi2-alpha(h) (binding) | HIC-1-isoform2(h) + RbAp48(m.s.) <==> HIC-1-isoform2(h):RbAp48(m.s.) (binding) | HIC-1-isoform2(h) + acetyl-CoA --p300(m.s.)--> HIC-1-isoform2(h){aceK314} + CoA (acetylation) | HIC-1-isoform2(h) --/ p57Kip2(m) (decrease of abundance) | HIC-1-isoform2(h) --/ cyclinD1(m) (decrease of abundance) | HIC1(h) --> HIC-1-isoform2(h) (expression). | HIC-1(h) --/ AXIN2(m) (transrepression) | HIC-1(h) --/ SP5(h) (transrepression) | HIC-1(h) --/ CCND1(h) (transrepression) | TCF-4(h) + beta-catenin(h) + HIC-1(h) <==> TCF-4(h):beta-catenin(h):HIC-1(h) (binding) | HIC-1(h) + MBD2(m.s.) <==> HIC-1(h):MBD2(m.s.) (binding) | mbd3(m.s.) + HIC-1(h) <==> mbd3(m.s.):HIC-1(h) (binding) | mbd3(h) + HIC-1(h) <==> mbd3(h):HIC-1(h) (binding) | HIC1(h) --> HIC-1(h) (expression). | HIC1(h) --> HIC-1-isoform1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
313 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 333 | N6-acetyllysine; alternate. | Swiss-Prot 53.0 | 333 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO);alternate. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr17 |
Promoter: 1903513 - 1905513 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 1903513 - 1905513 | GSE27584 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:14688019 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:12097291 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:14506157 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:14656076 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:9671399 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:11448914 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:15713962 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:12773202 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:16204069 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:12429618 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:17177027 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:14714493 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:11895880 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:16435073 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:16166431 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:9572497 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:15328171 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:15026333 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:17380894 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:15788647 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:15389252 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:11341745 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:15885882 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:16412291 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:16343268 |
chr17 |
Promoter: 1903513 - 1905513 | PMID:15507671 |