| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3091 |
Name | HIF1A |
Synonymous | HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78;hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor);HIF1A;hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
Definition | ARNT interacting protein|ARNT-interacting protein|HIF-1-alpha|PAS domain-containing protein 8|basic-helix-loop-helix-PAS protein MOP1|class E basic helix-loop-helix protein 78|hypoxia-inducible factor 1 alpha isoform I.3|hypoxia-inducible factor 1, alpha |
Position | 14q23.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
HIF-1alpha(h) + Hsp90(h) <==> HIF-1alpha(h):Hsp90(h) (binding) | HNF-4alpha2(h) + HIF-1alpha(h) <==> HNF-4alpha2(h):HIF-1alpha(h) (binding) | Smad3(h) + HIF-1alpha(h) <==> Smad3(h):HIF-1alpha(h) (binding) | HIF-1alpha(h) + p300(h) <==> HIF-1alpha(h):p300(h) (binding) | HIF-1alpha(h) + p53(h) <==> HIF-1alpha(h):p53(h) (binding) | HIF-1alpha(h) + CBP(v.s.) <==> HIF-1alpha(h):CBP(v.s.) (binding) | HIF-1alpha(h) + FIH-1(h) <==> HIF-1alpha(h):FIH-1(h) (binding) | HIF-1alpha(h) + VHL(h) <==> HIF-1alpha(h):VHL(h) (binding) | HIF-1alpha(h) --egln2(h)--> HIF-1alpha(h){hydP567} (hydroxylation) | HIF-1alpha(h) --HIF-PH2(h)--> HIF-1alpha(h){hydP567} (hydroxylation) | HIF-1alpha(h) --HIF-PH3(h)--> HIF-1alpha(h){hydP567} (hydroxylation) | HIF-1alpha(h) --egln2(h)--> HIF-1alpha(h){hydP564} (hydroxylation) | HIF-1alpha(h) --HIF-PH2(h)--> HIF-1alpha(h){hydP564} (hydroxylation) | HIF-1alpha(h) --HIF-PH3(h)--> HIF-1alpha(h){hydP564} (hydroxylation) | HIF-1alpha(h) --egln2(h)--> HIF-1alpha(h){hydP} (hydroxylation) | HIF-1alpha(h) + VHL(h):elongin B(h):elongin C(h) <==> HIF-1alpha(h):VHL(h):elongin B(h):elongin C(h) (binding) | HIF-1alpha(h) + n ubiquitin(h) --VHL(h)--> HIF-1alpha(h){ub(n)} (ubiquitination) | HIF-1alpha(h) + ATP --ERK2(r){p}--> HIF-1alpha(h){p} + ADP (phosphorylation) | HIF-1alpha(h) + JAB1(m) <==> HIF-1alpha(h):JAB1(m) (binding) | HIF-1alpha(h) + Hsp90(mo) <==> HIF-1alpha(h):Hsp90(mo) (binding) | HIF-1alpha(h) + SRC-1(h) <==> HIF-1alpha(h):SRC-1(h) (binding) | Ref-1(h) + HIF-1alpha(h) <==> Ref-1(h):HIF-1alpha(h) (binding) | HIF-1alpha(h) + mdm2(h) <==> HIF-1alpha(h):mdm2(h) (binding) | HIF-1alpha(h) + arnt(h) <==> HIF-1(h) (binding) | HIF-1alpha(h) + Per1(m) <==> HIF-1alpha(h):Per1(m) (binding) | p16INK4a-p14(h) + HIF-1alpha(h) <==> p16INK4a-p14(h):HIF-1alpha(h) (binding) | XAPC7(h) + HIF-1alpha(h) <==> XAPC7(h):HIF-1alpha(h) (binding) | BMAL1(h) + HIF-1alpha(h) <==> HIF-1alpha(h):BMAL1(h) (binding) | HIF-1alpha(h) + DAP3(h) <==> HIF-1alpha(h):DAP3(h) (binding) | brca1(h) + HIF-1alpha(h) <==> brca1(h):HIF-1alpha(h) (binding) | HIF-1alpha(h) --> NPPB(h) (DNA binding; transactivation). | HIF-1alpha(h) --> Epo(h) (DNA binding; transactivation). | HIF-1alpha(h) --> TFRC(h) (DNA binding). | HIF-1alpha(h) --> NTRK2(h) (DNA binding). | HIF-1alpha(h) --> RORA(m) (DNA binding). | HIF-1alpha(h) --> PFKFB3(h) (DNA binding). | HIF-1alpha(h) + HNF-4alpha(h) <==> HIF-1alpha(h):HNF-4alpha(h) (binding) | HIF-1alpha(h) + CT5.4(h) <==> HIF-1alpha(h):CT5.4(h) (binding) | HIF-1alpha(h) --> CEBPA(h) (DNA binding). | HIF-1alpha(h) --> CXCR4(h) (DNA binding). | HIF-1alpha(h) --> VEGFA(h) (DNA binding; transactivation). | HIF-1alpha(h) --> RPSA(h) (DNA binding). | HIF-1alpha(h) --> BCL2L1(h) (DNA binding). | HIF-1alpha(h) --> CP(h) (DNA binding). | HIF-1alpha(h) --> MUC1(h) (DNA binding). | HIF-1alpha(h) --> ENG(h) (DNA binding). | HIF-1alpha(h) --> TWIST1(h) (DNA binding). | HIF-1alpha(h) --> Egln1(m) (transactivation) | HIF-1alpha(h) --> HIF-1alpha(h) (translocation) | HIF-1alpha(h) --> SERPINE1(h) (DNA binding). | HIF-1alpha(h) --> CCL5(h) (DNA binding). | HIF-1alpha(h) --> EGLN1(h) (DNA binding). | HIF-1alpha(h) --> MIF(h) (DNA binding). | HIF-1alpha(h) --> TFF3(h) (transactivation) | HIF-1alpha(h) --> Nppa(r) (transactivation) | HIF-1alpha(h) --> CXCL12(h) (transactivation) | HIF-1alpha(h) --> TF(h) (DNA binding). | HIF-1alpha(h) --> EDN1(h) (DNA binding). | HIF-1alpha(h) + VHL(m.s.) <==> HIF-1alpha(h):VHL(m.s.) (binding) | HIF-1alpha(h) + n ubiquitin(h) --> HIF-1alpha(h){ub(n)} (ubiquitination) | HIF-1alpha(h) --> Pklr(r) (DNA binding). | HIF-1alpha(h) --> ALOX5AP(h) (DNA binding). | HIF-1alpha(h) --> PLAUR(h) (DNA binding). | HIF-1alpha(h) --> SLC16A3(h) (DNA binding). | HIF-1alpha(h) --> MIRN210(h) (DNA binding). | HIF1A(h) --> HIF-1alpha(h) (expression). | ET-1(m.s.) --> HIF-1alpha(h) (increase of abundance) | ET3(m.s.) --> HIF-1alpha(h) (increase of abundance) | TNF(h) --> HIF-1alpha(h) (increase of abundance) | IL-1alpha(m.s.) --> HIF-1alpha(h) (increase of abundance) | IFNalpha2a(h) --> HIF-1alpha(h) (increase of abundance) | HIF-1alpha(h) --> HIF-1alpha(h) (translocation) | JAB1(h) --> HIF-1alpha(h) (increase of abundance) | COPS2(h) --> HIF-1alpha(h) (increase of abundance) | HIF-1alpha-isoform1(h) --> TERT(h) (DNA binding; transactivation). | SSAT(h) + HIF-1alpha-isoform1(h) <==> SSAT(h):HIF-1alpha-isoform1(h) (binding) | RACK1(m.s.) + HIF-1alpha-isoform1(h) <==> RACK1(m.s.):HIF-1alpha-isoform1(h) (binding) | Hsp90(m.s.) + HIF-1alpha-isoform1(h) <==> Hsp90(m.s.):HIF-1alpha-isoform1(h) (binding) | HIF-1alpha-isoform1(h) --> VEGFA(h) (DNA binding; transactivation). | HIF1A(h) --> HIF-1alpha-isoform1(h) (expression). | HIF-1alpha-isoform2(h) + arnt(m.s.) <==> HIF-1alpha-isoform2(h):arnt(m.s.) (binding) | HIF-1alpha-isoform2(h) --> Epo(h) (DNA binding; transactivation). | HIF1A(h) --> HIF-1alpha-isoform2(h) (expression). | HIF1A(h) --> HIF1A(h) (expression). | hsa-miR-17-5p --/ HIF1A(h) (translational repression). | hsa-miR-20a --/ HIF1A(h) (translational repression). | hsa-miR-18a --/ HIF1A(h) (translational repression). | hsa-miR-155 --/ HIF1A(h) (increase of mRNA decay). | hsa-miR-199 --/ HIF1A(h) (increase of mRNA decay). | rno-miR-155 --/ HIF1A(h) (increase of mRNA decay). | rno-miR-199 --/ HIF1A(h) (increase of mRNA decay). | hsa-miR-135 --/ HIF1A(h) (increase of mRNA decay). | rno-miR-135 --/ HIF1A(h) (increase of mRNA decay). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
90 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 139 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 173 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 194 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 210 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 219 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 224 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 255 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 334 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 337 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 359 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 402 | 4-hydroxyproline. | Swiss-Prot 53.0 | 520 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 532 | N6-acetyllysine. | Swiss-Prot 53.0 | 564 | 4-hydroxyproline. | Swiss-Prot 53.0 | 758 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 780 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 800 | S-nitrosocysteine (Potential). | Swiss-Prot 53.0 | 803 | 3-hydroxyasparagine. | Swiss-Prot 53.0 | 796 | Phosphothreonine | 11983697 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr14 |
Promoter: 61230492 - 61232492 | Agilent_014791 |
chr14 |
Promoter: 61230492 - 61232492 | GoldenGate_Methylation_Cancer_Panel_I |
chr14 |
Promoter: 61230492 - 61232492 | GoldenGate_Methylation_Cancer_Panel_I |
chr14 |
Promoter: 61230492 - 61232492 | GSE27584 |
chr14 |
Promoter: 61230492 - 61232492 | GSE27584 |
chr14 |
Promoter: 61230492 - 61232492 | Agilent_014791_44K |
chr14 |
Promoter: 61230492 - 61232492 | Agilent_014791 |