Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3164

Name

NR4A1

Synonymous

GFRP1|HMR|N10|NAK-1|NGFIB|NP10|NUR77|TR3;nuclear receptor subfamily 4, group A, member 1;NR4A1;nuclear receptor subfamily 4, group A, member 1

Definition

ST-59|TR3 orphan receptor|early response protein NAK1|growth factor-inducible nuclear protein N10|hormone receptor|nerve growth factor IB nuclear receptor variant 1|nuclear hormone receptor NUR/77|nuclear receptor subfamily 4 group A member 1|orphan nucle

Position

12q13

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Nur77(h) + MVP(h) <==> Nur77(h):MVP(h) (binding)
Nur77(h) --> CYP11B2(h) (DNA binding; transactivation).
Nur77(h) --> NR3C1(h) (DNA binding).
Nur77(h) --> HSD3B2(h) (DNA binding).
Nur77(h) + ATP --> Nur77(h){pT} + ADP (phosphorylation)
NR4A1(h) --> Nur77(h) (expression).
Substance P(m.s.) --> Nur77(h) (increase of abundance)
Nur77(h) --> E2F1(h) (DNA binding; transactivation)
Nur77(h) --> SERPINE1(h) (DNA binding; transactivation).
Nur77(h) --> ALDOC(h) (DNA binding).
Nur77(h) --> POMC(h) (DNA binding).
NR4A1(h) --> Nur77(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

341Phosphoserine (by PKA) (By similarity).Swiss-Prot 53.0
351Phosphoserine (by PKA) (By similarity).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr12

Promoter: 50729958 - 50731958Agilent_014791

chr12

Promoter: 50722263 - 50724263Agilent_014791

chr12

Promoter: 50729958 - 50731958GSE27584

chr12

Promoter: 50729958 - 50731958GSE27584


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