Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3688

Name

ITGB1

Synonymous

CD29|FNRB|GPIIA|MDF2|MSK12|VLA-BETA|VLAB;integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12);ITGB1;integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

Definition

glycoprotein IIa|integrin VLA-4 beta subunit|integrin beta-1|very late activation protein, beta polypeptide

Position

10p11.2

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

alpha8-integrin(h) + LAP1(mo) + beta1-integrin(h) <==> LAP1(mo):alpha8-integrin(h):beta1-integrin(h) (binding)
LAP1(mo) + CD51(h) + beta1-integrin(h) <==> LAP1(mo):CD51(h):beta1-integrin(h) (binding)
TGFbeta1(h) + LAP1(h) + beta1-integrin(h) <==> TGFbeta1(h):LAP1(h):beta1-integrin(h) (binding)
LAP1(h) + CD51(h) + beta1-integrin(h) <==> LAP1(h):CD51(h):beta1-integrin(h) (binding)
beta1-integrin(h) + RACK1(h) <==> beta1-integrin(h):RACK1(h) (binding)
beta1-integrin(h) + ICAP-1alpha(h) <==> beta1-integrin(h):ICAP-1alpha(h) (binding)
beta1-integrin(h) + alpha-actinin(c) <==> beta1-integrin(h):alpha-actinin(c) (binding)
beta1-integrin(h) --> Pyk2-isoform1(h) (activation; phosphorylation)
beta1-integrin(h) + IGF-1R(h) <==> beta1-integrin(h):IGF-1R(h) (binding)
beta1-integrin(h) + IGF-1R(ha) <==> beta1-integrin(h):IGF-1R(ha) (binding)
beta1-integrin(h) + IRS-1(ha) <==> beta1-integrin(h):IRS-1(ha) (binding)
beta1-integrin(h) + Gab-1(ha) <==> beta1-integrin(h):Gab-1(ha) (binding)
beta1-integrin(h) --> Gab-1(ha){pY} (increase of phosphorylation)
beta1-integrin(h) --> Gab-1(ha):SHP-2(ha){pY542} (increase of phosphorylation)
beta1-integrin(h) + MK(h) <==> beta1-integrin(h):MK(h) (binding)
Lrp6(m) + beta1-integrin(h) <==> Lrp6(m):beta1-integrin(h) (binding)
RPTPzeta(r) + beta1-integrin(h) <==> RPTPzeta(r):beta1-integrin(h) (binding)
caveolin-1(h) + beta1-integrin(h) <==> caveolin-1(h):beta1-integrin(h) (binding)
beta1-integrin(h) + LAMA5(h) <==> beta1-integrin(h):LAMA5(h) (binding)
IGF-1R-beta-p97(h){pY} + beta1-integrin(h) <==> beta1-integrin(h):IGF-1R-beta-p97(h){pY} (binding)
beta1-integrin(h) + paxillin(h){pY} <==> beta1-integrin(h):paxillin(h){pY} (binding)
beta1-integrin(h) + FAK1(h){pY} <==> beta1-integrin(h):FAK1(h){pY} (binding)
beta1-integrin(h) + alpha-actinin(h) <==> beta1-integrin(h):alpha-actinin(h) (binding)
PKCalpha(h) + beta1-integrin(h) <==> PKCalpha(h):beta1-integrin(h) (binding)
beta1-integrin(h) --> FAK(h){pY} (increase of phosphorylation)
beta1-integrin(h) --> HEF1(h){pY} (increase of phosphorylation)
beta1-integrin(h) --> c-Cbl(h){pY} (increase of phosphorylation)
beta1-integrin(h) --> c-Cbl(h):CrkL(m.s.) (increase of binding)
beta1-integrin(h) --> HEF1(h):CrkL(m.s.) (increase of binding)
beta1-integrin(h) --> Cas(h){pY} (increase of phosphorylation)
beta1-integrin(h) --> Cas(h):Fyn(h){pY} (increase of binding)
beta1-integrin(h) --> SHP-2(h):Cas(h) (increase of binding)
beta1-integrin(h) --> HEF1(h):CrkL(h) (increase of binding)
beta1-integrin(h) --> Cas(h):CrkL(h) (increase of binding)
beta1-integrin(h) --> Lyn(h){pY} (increase of phosphorylation)
beta1-integrin(h) + TGC(h) <==> beta1-integrin(h):TGC(h) (binding)
Fibronectin-p42(m.s.) + TGC(h) + beta1-integrin(h) <==> Fibronectin-p42(m.s.):beta1-integrin(h):TGC(h) (binding)
beta1-integrin(h) + fibronectin(m.s.) <==> beta1-integrin(h):fibronectin(m.s.) (binding)
beta1-integrin(h) + Fibronectin-p42(m.s.) <==> beta1-integrin(h):Fibronectin-p42(m.s.) (binding)
uPAR(h) + beta1-integrin(h) <==> uPAR(h):beta1-integrin(h) (binding)
ErbB2(m.s.) + beta1-integrin(h) <==> ErbB2(m.s.):beta1-integrin(h) (binding)
FAK1(h) + beta1-integrin(h) <==> FAK1(h):beta1-integrin(h) (binding)
alpha4-integrin(h) + beta1-integrin(h) <==> alpha4-integrin(h):beta1-integrin(h) (binding)
Itgb1(h) --> beta1-integrin(h) (expression).
LAT(h) --> beta1-integrin(h) (activation)
IGF-1(h) --> IRS-1(ha){pY} (increase of phosphorylation)
beta1A-integrin(h) + MIBP(h) <==> beta1A-integrin(h):MIBP(h) (binding)
beta1A-integrin(h) + ICAP-1(r) <==> beta1A-integrin(h):ICAP-1(r) (binding)
beta1A-integrin(h) + melusin(r) <==> beta1A-integrin(h):melusin(r) (binding)
beta1A-integrin(h) + talin(h) <==> beta1A-integrin(h):talin(h) (binding)
beta1A-integrin(h) + Syk(h) <==> beta1A-integrin(h):Syk(h) (binding)
beta1A-integrin(h) --> EGFR(m){pY} (increase of phosphorylation)
beta1A-integrin(h) --> Src(m){pY424} (increase of phosphorylation)
beta1A-integrin(h) --> Cas(m){pY} (increase of phosphorylation)
beta1A-integrin(h) + TGC(ha) <==> beta1A-integrin(h):TGC(ha) (binding)
Itgb1(h) --> beta1A-integrin(h) (expression).
beta1D-integrin(h) + MIBP(h) <==> beta1D-integrin(h):MIBP(h) (binding)
beta1D-integrin(h) + melusin(r) <==> beta1D-integrin(h):melusin(r) (binding)
beta1D-integrin(h) + talin(h) <==> beta1D-integrin(h):talin(h) (binding)
beta1D-integrin(h) + TGC(ha) <==> beta1D-integrin(h):TGC(ha) (binding)
Itgb1(h) --> beta1D-integrin(h) (expression).
Itgb1(h) --> beta1B-integrin(h) (expression).
Itgb1(h) --> beta1C-integrin(h) (expression).
Itgb1(h) --> beta1C-2-integrin(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

50N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
94N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
97N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
212N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
269N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
363N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
406N-linked (GlcNAc...).Swiss-Prot 53.0
417N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
481N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
520N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
584N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
669N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
783Phosphotyrosine (By similarity).Swiss-Prot 53.0
788Phosphothreonine14660602Phospho.ELM 6.0
789Phosphothreonine14660602Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr10

Promoter: 33286704 - 33288704Agilent_014791

chr10

Promoter: 33286328 - 33288328Agilent_014791

chr10

Promoter: 33286704 - 33288704GoldenGate_Methylation_Cancer_Panel_I

chr10

Promoter: 33286328 - 33288328GoldenGate_Methylation_Cancer_Panel_I

chr10

Promoter: 33286328 - 33288328GSE27584

chr10

Promoter: 33286704 - 33288704GSE27584

chr10

Promoter: 33286704 - 33288704Agilent_014791_44K

chr10

Promoter: 33286328 - 33288328Agilent_014791_44K


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