Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4149

Name

MAX

Synonymous

bHLHd4;MYC associated factor X;MAX;MYC associated factor X

Definition

class D basic helix-loop-helix protein 4|protein max

Position

14q23

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Max-isoform2(h) --> Ptma(r) (DNA binding; transregulation).
Max-isoform2(h) --> ODC1(h) (DNA binding; transregulation).
Max-isoform2(h) --> DHFR(ha) (DNA binding).
Max-isoform2(h) + c-Myc(h) <==> Max-isoform2(h):c-Myc(h) (binding).
c-Myc(c) + Max-isoform2(h) <==> c-Myc(c):Max-isoform2(h) (binding).
c-Myc(r) + Max-isoform2(h) <==> c-Myc(r):Max-isoform2(h) (binding).
c-Myc(m) + Max-isoform2(h) <==> c-Myc(m):Max-isoform2(h) (binding).
N-Myc(m) + Max-isoform2(h) <==> N-Myc(m):Max-isoform2(h) (binding).
Mxi1(h) + Max-isoform2(h) <==> Mxi1(h):Max-isoform2(h) (binding).
Mad1(h) + Max-isoform2(h) <==> Mad1(h):Max-isoform2(h) (binding).
Max-isoform3(h) + Max-isoform2(h) <==> Max-isoform3(h):Max-isoform2(h) (binding).
N-Myc(h) + Max-isoform2(h) <==> N-Myc(h):Max-isoform2(h) (binding).
L-Myc-1(long form)(h) + Max-isoform2(h) <==> L-Myc-1(long form)(h):Max-isoform2(h) (binding).
L-Myc1(m) + Max-isoform2(h) <==> L-Myc1(m):Max-isoform2(h) (binding).
L-Myc-1(x) + Max-isoform2(h) <==> L-Myc-1(x):Max-isoform2(h) (binding).
L-Myc-2(x) + Max-isoform2(h) <==> L-Myc-2(x):Max-isoform2(h) (binding).
Mad1(m) + Max-isoform2(h) <==> Mad1(m):Max-isoform2(h) (binding).
Mad3(m) + Max-isoform2(h) <==> Mad3(m):Max-isoform2(h) (binding).
Mad4(m) + Max-isoform2(h) <==> Mad4(m):Max-isoform2(h) (binding).
Max-isoform2(h) + Rox(h) <==> Max-isoform2(h):Rox(h) (binding).
Max-isoform2(h) + ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> Max-isoform2(h){p} + ADP (phosphorylation)
Max-isoform2(h) + Max-isoform2(h) <==> Max-isoform2(h):Max-isoform2(h) (binding).
Max-isoform2(h) + acetyl-CoA --p300(h)--> Max-isoform2(h){aceK57} + CoA (acetylation)
Max-isoform2(h) + 4 acetyl-CoA --p300(h)--> Max-isoform2(h){aceK31}{aceK57}{aceK144}{aceK145} + 4 CoA (acetylation)
Max-isoform2(h) + 3 acetyl-CoA --p300(h)--> Max-isoform2(h){aceK57}{aceK144}{aceK145} + 3 CoA (acetylation)
2 Max-isoform2(h) <==> (Max-isoform2(h))2 (oligomerization)
c-Myc(m) + Max-isoform2(h) <==> c-Myc(m):Max-isoform2(h) (binding)
MAX(h) --> Max-isoform2(h) (expression).
Max-isoform1(h) + c-Myc(h) <==> Max-isoform1(h):c-Myc(h) (binding).
N-Myc(m) + Max-isoform1(h) <==> N-Myc(m):Max-isoform1(h) (binding).
Mxi1(h) + Max-isoform1(h) <==> Mxi1(h):Max-isoform1(h) (binding).
Mad1(h) + Max-isoform1(h) <==> Mad1(h):Max-isoform1(h) (binding).
Max-isoform3(h) + Max-isoform1(h) <==> Max-isoform3(h):Max-isoform1(h) (binding).
N-Myc(h) + Max-isoform1(h) <==> N-Myc(h):Max-isoform1(h) (binding).
Mad1(m) + Max-isoform1(h) <==> Mad1(m):Max-isoform1(h) (binding).
Max-isoform1(h) + ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> Max-isoform1(h){p} + ADP (phosphorylation)
Max-isoform1(h) --Caspase-5(h)--> protein remnants (processing)
Max-isoform1(h) --Caspase-7(h)--> protein remnants (processing)
Max-isoform1(h) + Max-isoform1(h) <==> Max-isoform1(h):Max-isoform1(h) (binding).
Max-isoform1(h) + TEF-1(h) <==> Max-isoform1(h):TEF-1(h) (binding)
TEF-1(h){pS102} + Max-isoform1(h) <==> TEF-1(h){pS102}:Max-isoform1(h) (binding)
MAX(h) --> Max-isoform1(h) (expression).
p38alpha(h) + Max(h) <==> p38alpha(h):Max(h) (binding)
Max(h) + c-Myc(h) + GCN5(h) + trrap(h) <==> Max(h):c-Myc(h):GCN5(h):trrap(h) (binding)
Max(h) --> cdc25A(h) (DNA binding; transactivation).
Max(h) --> B1AR(s) (DNA binding).
Mad(h) + Max(h) <==> Mad(h):Max(h) (binding)
c-Myc(h) + Max(h) <==> c-Myc(h):Max(h) (binding) [f
Max(h) + Mad(h) + sin3a(m) <==> Max(h):Mad(h):sin3a(m) (binding)
Max(h) + Mxi1(h) <==> Max(h):Mxi1(h) (binding)
Max(h) + JLP(m) <==> Max(h):JLP(m) (binding)
Max(h) --> TERT(h) (DNA binding; transregulation).
p300(h) + Max(h) <==> p300(h):Max(h) (binding)
Max(h) + PARP(h) <==> Max(h):PARP(h) (binding)
Max(h) + TEF-1-xbb2(h) <==> Max(h):TEF-1-xbb2(h) (binding)
Max(h) + TEF-1(r) <==> Max(h):TEF-1(r) (binding)
c-Myc(m.s.) + Max(h) <==> c-Myc(m.s.):Max(h) (binding)
c-Myc(m.s.){aceK} + Max(h) <==> c-Myc(m.s.){aceK}:Max(h) (binding)
Max(h) + CBP(h) <==> Max(h):CBP(h) (binding)
Max(h) --> Hmga1(m) (DNA binding).
Max(h) + 2 acetyl-CoA --> Max(h){aceK144}{aceK145} + 2 CoA (acetylation)
Max(h) + acetyl-CoA --p300(h)--> Max(h){aceK} + CoA (acetylation)
2 Max(h) <==> (Max(h))2 (binding)
Max(h) + Mad3(m) <==> Max(h):Mad3(m) (binding)
Max(h) + Mad4(m) <==> Max(h):Mad4(m) (binding)
Max(h) + c-Myc(h) <==> Max(h):c-Myc(h) (binding)
Max(h) + plekhf2(h) <==> Max(h):plekhf2(h) (binding)
MAX(h) --> Max(h) (expression).
ORC1(h) --> Max(h) (binding)
Max-isoform3(h) + c-Myc(h) <==> Max-isoform3(h):c-Myc(h) (binding).
Max-isoform3(h) + Max-isoform2(h) <==> Max-isoform3(h):Max-isoform2(h) (binding).
Max-isoform3(h) + Max-isoform1(h) <==> Max-isoform3(h):Max-isoform1(h) (binding).
Max-isoform3(h) + Max-isoform3(h) <==> Max-isoform3(h):Max-isoform3(h) (binding).
MAX(h) --> Max-isoform3(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

2Phosphoserine.Swiss-Prot 53.0
11Phosphoserine.Swiss-Prot 53.0
66N6-acetyllysine (Probable).Swiss-Prot 53.0
123Phosphotyrosine.Swiss-Prot 53.0
153N6-acetyllysine; alternate.Swiss-Prot 53.0
154N6-acetyllysine; alternate.Swiss-Prot 53.0
123Phosphotyrosine15592455Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr14

 Promoter: 64638480 - 64640480Agilent_014791

chr14

 Promoter: 64638480 - 64640480GSE27584

chr14

 Promoter: 64638480 - 64640480GSE27584

chr14

 Promoter: 64638480 - 64640480GSE27584

chr14

 Promoter: 64638480 - 64640480GSE27584

chr14

 Promoter: 64638480 - 64640480GSE27584

chr14

 Promoter: 64638480 - 64640480GSE27584

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