| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4436 |
Name | MSH2 |
Synonymous | COCA1|FCC1|HNPCC|HNPCC1|LCFS2;mutS homolog 2;MSH2;mutS homolog 2 |
Definition | DNA mismatch repair protein Msh2|hMSH2|mutS homolog 2, colon cancer, nonpolyposis type 1 |
Position | 2p21 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
ER-alpha-L(h) + MSH-2(h) <==> ER-alpha-L(h):MSH-2(h) (binding) | ER-beta-isoform1(h) + MSH-2(h) <==> ER-beta-isoform1(h):MSH-2(h) (binding) | PCNA(h) + MSH-2(h) <==> PCNA(h):MSH-2(h) (binding) | MSH2(h) --> MSH-2(h) (expression). | ER-alpha(h) + MSH2(h) <==> ER-alpha(h):MSH2(h) (binding) | ER-beta(h) + MSH2(h) <==> ER-beta(h):MSH2(h) (binding) | brca1(h) + MSH2(h) <==> brca1(h):MSH2(h) (binding) | MSH2(h) + GTBP(h) <==> MSH2(h):GTBP(h) (binding) | PCNA(h) + MSH2(h) <==> PCNA(h):MSH2(h) (binding) | MSH2(h) + PMS2(h) <==> MSH2(h):PMS2(h) (binding) | MSH2(h) + MLH1(h) <==> MSH2(h):MLH1(h) (binding) | PMS2(h) + MSH2(h) <==> PMS2(h):MSH2(h) (binding) | PMS2(h) + MLH1(h) + MSH2(h) <==> PMS2(h):MLH1(h):MSH2(h) (binding) | BLM(h) + MSH2(h) <==> BLM(h):MSH2(h) (binding) | MSH2(h) + p53(h) <==> MSH2(h):p53(h) (binding) | Rad51(h) + MSH2(h) <==> Rad51(h):MSH2(h) (binding) | RFC4(h) + RFC2(h) + MLH1(h) + MSH2(h) + RECC1(h) + BLM(h) + ATM(h) + brca1(h) + GTBP(h) <==> RFC4(h):RFC2(h):MLH1(h):MSH2(h):RECC1(h):BLM(h):ATM(h):brca1(h):GTBP(h) (binding) | Rad50(h) + MSH2(h) <==> Rad50(h):MSH2(h) (binding) | ATM(h) + MSH2(h) <==> ATM(h):MSH2(h) (binding) | BLM(h) + Rad50(h) + MSH2(h) + ATM(h) + brca1(h) + RECC1(h) <==> BLM(h):Rad50(h):MSH2(h):ATM(h):brca1(h):RECC1(h) (binding) | brca1(m.s.) + MSH2(h) <==> brca1(m.s.):MSH2(h) (binding) | MSH2(h) + GCN5(h) <==> MSH2(h):GCN5(h) (binding) | MSH2(h) + GTBP(h) + brca1(m.s.) + GCN5(h) + trrap(h) <==> MSH2(h):GTBP(h):brca1(m.s.):GCN5(h):trrap(h) (binding) | TAFII30(h) + TAF(II)31(h) + supt3h(h) + ADA3(h) + PAF65B(h) + MSH2(h) + GTBP(h) + trrap(h) + GCN5(h) + brca1(m.s.) <==> TAFII30(h):TAF(II)31(h):supt3h(h):ADA3(h):PAF65B(h):MSH2(h):GTBP(h):trrap(h):GCN5(h):brca1(m.s.) (binding) | PRL3(h) + MSH2(h) <==> PRL3(h):MSH2(h) (binding) | MSH2(h) + CBP(h) <==> MSH2(h):CBP(h) (binding) | MSH2(h) --> MSH2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for MSH2 | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 47482267 - 47484267 | Agilent_014791 |
chr2 |
Promoter: 47482267 - 47484267 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 47482267 - 47484267 | GSE27584 |
chr2 |
Promoter: 47482267 - 47484267 | Agilent_014791_44K |
chr2 |
Promoter: 47482267 - 47484267 | Agilent_014791 |
chr2 |
Promoter: 47482267 - 47484267 | PMID:17219447 |
chr2 |
Promoter: 47482267 - 47484267 | PMID:15498213 |
chr2 |
Promoter: 47482267 - 47484267 | PMID:16258501 |
chr2 |
Promoter: 47482267 - 47484267 | PMID:15662588 |