Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4436

Name

MSH2

Synonymous

COCA1|FCC1|HNPCC|HNPCC1|LCFS2;mutS homolog 2;MSH2;mutS homolog 2

Definition

DNA mismatch repair protein Msh2|hMSH2|mutS homolog 2, colon cancer, nonpolyposis type 1

Position

2p21

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

ER-alpha-L(h) + MSH-2(h) <==> ER-alpha-L(h):MSH-2(h) (binding)
ER-beta-isoform1(h) + MSH-2(h) <==> ER-beta-isoform1(h):MSH-2(h) (binding)
PCNA(h) + MSH-2(h) <==> PCNA(h):MSH-2(h) (binding)
MSH2(h) --> MSH-2(h) (expression).
ER-alpha(h) + MSH2(h) <==> ER-alpha(h):MSH2(h) (binding)
ER-beta(h) + MSH2(h) <==> ER-beta(h):MSH2(h) (binding)
brca1(h) + MSH2(h) <==> brca1(h):MSH2(h) (binding)
MSH2(h) + GTBP(h) <==> MSH2(h):GTBP(h) (binding)
PCNA(h) + MSH2(h) <==> PCNA(h):MSH2(h) (binding)
MSH2(h) + PMS2(h) <==> MSH2(h):PMS2(h) (binding)
MSH2(h) + MLH1(h) <==> MSH2(h):MLH1(h) (binding)
PMS2(h) + MSH2(h) <==> PMS2(h):MSH2(h) (binding)
PMS2(h) + MLH1(h) + MSH2(h) <==> PMS2(h):MLH1(h):MSH2(h) (binding)
BLM(h) + MSH2(h) <==> BLM(h):MSH2(h) (binding)
MSH2(h) + p53(h) <==> MSH2(h):p53(h) (binding)
Rad51(h) + MSH2(h) <==> Rad51(h):MSH2(h) (binding)
RFC4(h) + RFC2(h) + MLH1(h) + MSH2(h) + RECC1(h) + BLM(h) + ATM(h) + brca1(h) + GTBP(h) <==> RFC4(h):RFC2(h):MLH1(h):MSH2(h):RECC1(h):BLM(h):ATM(h):brca1(h):GTBP(h) (binding)
Rad50(h) + MSH2(h) <==> Rad50(h):MSH2(h) (binding)
ATM(h) + MSH2(h) <==> ATM(h):MSH2(h) (binding)
BLM(h) + Rad50(h) + MSH2(h) + ATM(h) + brca1(h) + RECC1(h) <==> BLM(h):Rad50(h):MSH2(h):ATM(h):brca1(h):RECC1(h) (binding)
brca1(m.s.) + MSH2(h) <==> brca1(m.s.):MSH2(h) (binding)
MSH2(h) + GCN5(h) <==> MSH2(h):GCN5(h) (binding)
MSH2(h) + GTBP(h) + brca1(m.s.) + GCN5(h) + trrap(h) <==> MSH2(h):GTBP(h):brca1(m.s.):GCN5(h):trrap(h) (binding)
TAFII30(h) + TAF(II)31(h) + supt3h(h) + ADA3(h) + PAF65B(h) + MSH2(h) + GTBP(h) + trrap(h) + GCN5(h) + brca1(m.s.) <==> TAFII30(h):TAF(II)31(h):supt3h(h):ADA3(h):PAF65B(h):MSH2(h):GTBP(h):trrap(h):GCN5(h):brca1(m.s.) (binding)
PRL3(h) + MSH2(h) <==> PRL3(h):MSH2(h) (binding)
MSH2(h) + CBP(h) <==> MSH2(h):CBP(h) (binding)
MSH2(h) --> MSH2(h) (expression).

Post Transcriptional Modification   [Top]

There is no record for MSH2

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

Promoter: 47482267 - 47484267Agilent_014791

chr2

Promoter: 47482267 - 47484267GoldenGate_Methylation_Cancer_Panel_I

chr2

Promoter: 47482267 - 47484267GSE27584

chr2

Promoter: 47482267 - 47484267Agilent_014791_44K

chr2

Promoter: 47482267 - 47484267Agilent_014791

chr2

Promoter: 47482267 - 47484267PMID:17219447

chr2

Promoter: 47482267 - 47484267PMID:15498213

chr2

Promoter: 47482267 - 47484267PMID:16258501

chr2

Promoter: 47482267 - 47484267PMID:15662588


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