| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4683 |
Name | NBN |
Synonymous | AT-V1|AT-V2|ATV|NBS|NBS1|P95;nibrin;NBN;nibrin |
Definition | Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex |
Position | 8q21 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Rad50(h) + NBS1(h) <==> Rad50(h):NBS1(h) (binding) | mdm2(h) + NBS1(h) <==> mdm2(h):NBS1(h) (binding) | NBS1(h) + ATP --> NBS1(h){pS343} + ADP (phosphorylation) | Mre11(h) + NBS1(h) + Rad50(h) <==> Mre11(h):NBS1(h):Rad50(h) (binding) | WS(h) + NBS1(h) + Mre11(h) + Rad50(h) <==> WS(h):Mre11(h):NBS1(h):Rad50(h) (binding) | BARD1(h) + NBS1(h) + TOP2BP1(h) + brca1(h) <==> BARD1(h):NBS1(h):TOP2BP1(h):brca1(h) (binding) | Mre11(h) + NBS1(h) + Bach1(h) + Rad50(h) + TOP2BP1(h) + BARD1(h) <==> Mre11(h):NBS1(h):Bach1(h):Rad50(h):TOP2BP1(h):BARD1(h) (binding) | Mre11(h) + NBS1(h) + CtIP(h) + Rad50(h) + brca1(h) <==> Mre11(h):NBS1(h):CtIP(h):Rad50(h):brca1(h) (binding) | brca1(h) + NBS1(h) <==> brca1(h):NBS1(h) (binding) | BLM(h) + NBS1(h) <==> BLM(h):NBS1(h) (binding) | NBS1(h) + Rad50(h) + Mre11(h) + h2ax(h){pS140} <==> NBS1(h):Rad50(h):Mre11(h):h2ax(h){pS140} (binding) | NBS1(h) + p300(h) <==> NBS1(h):p300(h) (binding) | NBS1(h) --> Chk1(h){pS317} (increase of phosphorylation) | NBN(h) --> NBS1(h) (expression). | Mre11(h) --> NBS1(h) (increase of abundance) | mdm2(h) + NBS1(h) <==> mdm2(h):NBS1(h) (binding) | NBS1(h) + mdm2-isoform1(m) <==> NBS1(h):mdm2-isoform1(m) (binding) | WS(h) + NBS1(h) <==> WS(h):NBS1(h) (binding) | NBS1(h) + ATP --ATM(m.s.)--> NBS1(h){pS343} + ADP (phosphorylation) | NBS1(h) + ATP --ATR(m.s.)--> NBS1(h){pS343} + ADP (phosphorylation) | NBS1(h) + ATP --DNA-PK(m.s.)--> NBS1(h){pS343} + ADP (phosphorylation) | NBS1(h) --> Chk2(h){pT68} (increase of phosphorylation) | NBN(h) --> NBS1(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
278 | Phosphoserine (by ATM). | Swiss-Prot 53.0 | 343 | Phosphoserine (by ATM). | Swiss-Prot 53.0 | 397 | Phosphoserine. | Swiss-Prot 53.0 | 432 | Phosphoserine. | Swiss-Prot 53.0 | 615 | Phosphoserine. | Swiss-Prot 53.0 | 343 | Phosphoserine (ATM) | 11252893;10839545;10839544;15302935;15279770 | Phospho.ELM 6.0 | 397 | Phosphoserine (ATM) | 11252893;10839545 | Phospho.ELM 6.0 | 278 | Phosphoserine (ATM) | 10839544;15279770 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr8 |
Promoter: 91065575 - 91067575 | Agilent_014791 |
chr8 |
Promoter: 91065575 - 91067575 | GSE27584 |