| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 472 |
Name | ATM |
Synonymous | AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1;ATM serine/threonine kinase;ATM;ATM serine/threonine kinase |
Definition | A-T mutated|AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated|serine-protein kinase ATM |
Position | 11q22-q23 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
mdm2(h) + ATM(h) <==> mdm2(h):ATM(h) (binding) | ATM(h) + p53(h) <==> ATM(h):p53(h) (binding) | ATM(h) --Caspase-3(h)--> protein remnants (processing) | ATM(h) --Caspase-7(h)--> protein remnants (processing) | ATM(h) + ATP --> ATM(h){pS1981} + ADP (phosphorylation; automodification) | ATM(h) + MOF(h) <==> ATM(h):MOF(h) (binding) | ATM(h) + Wip1(h) <==> ATM(h):Wip1(h) (binding) | Wip1(m.s.) + ATM(h) <==> Wip1(m.s.):ATM(h) (binding) | ATM(h) --> protein remnants (cleavage) | ATM(h) --Caspase-3(m.s.)--> ATM-p210(h) + ATM-p150(h) + protein remnants (cleavage) | ATM(h) --> ATM-p210(h) + protein remnants (cleavage) | ATM(h) + BAAT1(h) <==> ATM(h):BAAT1(h) (binding) | ATM(h) --> ATM(h) (translocation) | ATM(h) + PP2A(h) <==> ATM(h):PP2A(h) (binding) | ATM(h) + ATP --> ATM(h){pS1981} + ADP (phosphorylation) | ATM(h) --> brca1(h):Mre11(h) (increase of binding) | RFC4(h) + RFC2(h) + MLH1(h) + MSH2(h) + RECC1(h) + BLM(h) + ATM(h) + brca1(h) + GTBP(h) <==> RFC4(h):RFC2(h):MLH1(h):MSH2(h):RECC1(h):BLM(h):ATM(h):brca1(h):GTBP(h) (binding) | ATM(h) + brca1(h) <==> ATM(h):brca1(h) (binding) | ATM(h) + RECC1(h) <==> ATM(h):RECC1(h) (binding) | GTBP(h) + ATM(h) <==> GTBP(h):ATM(h) (binding) | BLM(h) + ATM(h) <==> BLM(h):ATM(h) (binding) | ATM(h) + Rad50(h) <==> ATM(h):Rad50(h) (binding) | ATM(h) + Mre11(h) <==> ATM(h):Mre11(h) (binding) | ATM(h) + MSH2(h) <==> ATM(h):MSH2(h) (binding) | ATM(h) + MLH1(h) <==> ATM(h):MLH1(h) (binding) | BLM(h) + Rad50(h) + MSH2(h) + ATM(h) + brca1(h) + RECC1(h) <==> BLM(h):Rad50(h):MSH2(h):ATM(h):brca1(h):RECC1(h) (binding) | ATM(h) --> brca1(h){p}n (increase of phosphorylation) | ATM(h) + ATP --> ATM(h){p} + ADP (phosphorylation) | ATM(h) + ATP --> ATM(h){p} + ADP (automodification) | ATM(h) + obfc2b(h) <==> ATM(h):obfc2b(h) + ATM(h):obfc2b(h) (binding) | ATM(h) + Apak(h) <==> ATM(h):Apak(h) (binding) | HDAC1(h) + RNF96(h) + Apak(h) + ATM(h) + p53(h) <==> HDAC1(h):RNF96(h):Apak(h):ATM(h):p53(h) (binding) | p53(h) + Apak(h) + ATM(h) <==> p53(h):Apak(h):ATM(h) (binding) | H2O2 --> ATM(h) (activation) | ATM(h) --> ATM(h) (expression). | ATM(h) --> ATM(h) (translocation) | ATM(h){pS1981} --PP2A(h)--> ATM(h) + p (dephosphorylation) | p53(h) + ATP --ATM(h)--> p53(h){pS15} + ADP (phosphorylation) | p53(h) + ATP --ATM(h)--> p53(h){pS20} + ADP (phosphorylation) | Chk2(h) + ATP --ATM(h)--> Chk2(h){pT68} + ADP (phosphorylation) | 53BP1(h) + ATP --ATM(h)--> 53BP1(h){p} + ADP (phosphorylation) | LKB1(m) + ATP --ATM(h)--> LKB1(m){pT366} + ADP (phosphorylation) | Chk1(v.s.) + ATP --ATM(h)--> Chk1(v.s.){pS345} + ADP (phosphorylation) | mdm2(h) + ATP --ATM(h)--> mdm2(h){p} + ADP (phosphorylation) | mdm2(h) + ATP --ATM(h)--> mdm2(h){pS395} + ADP (phosphorylation) | p53(m.s.) + ATP --ATM(h)--> p53(m.s.){pS15} + ADP (phosphorylation) | Bid(m) + 2 ATP --ATM(h)--> Bid(m){pS61}{pS78} + 2 ADP (phosphorylation) | Bid(h) + ATP --ATM(h)--> Bid(h){pS78} + ADP (phosphorylation) | Artemis-isoform1(h) + 3 ATP --ATM(h)--> Artemis-isoform1(h){pS503}{pS516}{pS645} + 3 ADP (phosphorylation) | Artemis(h) + ATP --ATM(h)--> Artemis(h){pS645} + ADP (phosphorylation) | Mdm4(h) + ATP --ATM(h)--> Mdm4(h){pS403} + ADP (phosphorylation) | CREB(h) + 3 ATP --ATM(h)--> CREB(h){pT100}{pS111}{pS121} + 3 ADP (phosphorylation) | CREB1(h) + ATP --ATM(h)--> CREB1(h){pS121} + ADP (phosphorylation) | p53(m.s.) + ATP --ATM(h)--> p53(m.s.){p} + ADP (phosphorylation) | BAF170(h) + ATP --ATM(h)--> BAF170(h){pS969} + ADP (phosphorylation) | MOF(h) + ATM(h) <==> MOF(h):ATM(h) (binding) | ATM(h) + MOF-isoform1(h) <==> ATM(h):MOF-isoform1(h) (binding) | 2 ATM(h) <==> (ATM(h))2 (oligomerization) | ATM(h) + ATP --> ATM(h){pS1981} + ADP (phosphorylation; automodification) | ATM(h) + 2 ATP --ATM(m.s.)--> ATM(h){pS440}{pS2761} + 2 ADP (phosphorylation) | ATM(h) + 2 ATP --ATR(m.s.)--> ATM(h){pS440}{pS2761} + 2 ADP (phosphorylation) | ATM(h) + ATP --DNA-PK(m.s.)--> ATM(h){pS440} + ADP (phosphorylation) | ATM(h) --/ bbc3(h) (transrepression) | ATM(h) --/ P53AIP1(h) (transrepression) | ATM(h) --/ PMAIP1(h) (transrepression) | ATM(h) --/ CDKN1A(h) (transrepression) | ATM(h) --/ SFN(h) (transrepression) | ATM(h) --> ATM(h) (expression). | ATM(h){pS1981} --Wip1(h)--> ATM(h) + p (dephosphorylation) | ATM(h){pS1981} --Wip1(m.s.)--> ATM(h) + p (dephosphorylation) | ATM(h){pS1981} --PP2A(m.s.)--> ATM(h) + p (dephosphorylation) | p53(m.s.) + ATP --ATM(h)--> p53(m.s.){pS15} + ADP (phosphorylation) | Bid(m) + 2 ATP --ATM(h)--> Bid(m){pS61}{pS78} + 2 ADP (phosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
1981 | Phosphoserine (by autocatalysis). | Swiss-Prot 53.0 | 1981 | Phosphoserine (ATM) | 12556884;15302935 | Phospho.ELM 6.0 | 1987 | Phosphoserine | 15302935 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr11 |
Promoter: 107597269 - 107599269 | GSE27584 |
chr11 |
Promoter: 107597269 - 107599269 | Agilent_014791_44K |
chr11 |
Promoter: 107597269 - 107599269 | Agilent_014791 |
chr11 |
Promoter: 107597269 - 107599269 | PMID:17378912 |
chr11 |
Promoter: 107661829 - 107663829 | PMID:17378912 |
chr11 |
Promoter: 107597269 - 107599269 | PMID:15386372 |
chr11 |
Promoter: 107661829 - 107663829 | PMID:15386372 |