| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4763 |
Name | NF1 |
Synonymous | NFNS|VRNF|WSS;neurofibromin 1;NF1;neurofibromin 1 |
Definition | neurofibromatosis-related protein NF-1|neurofibromin |
Position | 17q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
neurofibromin1(h) --> STMN1(h) (DNA binding). | neurofibromin1(h) + Ras(m.s.) <==> neurofibromin1(h):Ras(m.s.) (binding) | HDAC1(h) + neurofibromin1(h) <==> HDAC1(h):neurofibromin1(h) (binding) | pRb(h) + neurofibromin1(h) <==> pRb(h):neurofibromin1(h) (binding) | neurofibromin1(h) --> GUCY1B3(h) (DNA binding). | neurofibromin1(h) + CRMP2(m) <==> neurofibromin1(h):CRMP2(m) (binding) | neurofibromin1(h) + 14-3-3(m) <==> neurofibromin1(h):14-3-3(m) (binding) | neurofibromin1(h) + NRP(m) <==> neurofibromin1(h):NRP(m) (binding) | neurofibromin1(h) + PUR1(m) <==> neurofibromin1(h):PUR1(m) (binding) | neurofibromin1(h) + gC1qR(m) <==> neurofibromin1(h):gC1qR(m) (binding) | neurofibromin1(h) + SET(m) <==> neurofibromin1(h):SET(m) (binding) | neurofibromin1(h) + rpl22(m) <==> neurofibromin1(h):rpl22(m) (binding) | neurofibromin1(h) + beta-adaptin2(m) <==> neurofibromin1(h):beta-adaptin2(m) (binding) | neurofibromin1(h) + tubb2b(m) <==> neurofibromin1(h):tubb2b(m) (binding) | neurofibromin1(h) + Beta-tubulin-4(m) <==> neurofibromin1(h):Beta-tubulin-4(m) (binding) | neurofibromin1(h) + alpha-tubulin 1B(m) <==> neurofibromin1(h):alpha-tubulin 1B(m) (binding) | neurofibromin1(h) + Synapsin-1(m) <==> neurofibromin1(h):Synapsin-1(m) (binding) | neurofibromin1(h) + Synaptojanin1(m) <==> neurofibromin1(h):Synaptojanin1(m) (binding) | neurofibromin1(h) + dynamin1(m) <==> neurofibromin1(h):dynamin1(m) (binding) | neurofibromin1(h) + EF1G(m) <==> neurofibromin1(h):EF1G(m) (binding) | neurofibromin1(h) + AP180(m) <==> neurofibromin1(h):AP180(m) (binding) | neurofibromin1(h) + hydroxyacylglutathione hydrolase(m) <==> neurofibromin1(h):hydroxyacylglutathione hydrolase(m) (binding) | neurofibromin1(h) + G-alpha-o(m) <==> neurofibromin1(h):G-alpha-o(m) (binding) | neurofibromin1(h) + glutamate dehydrogenase 1, mitochondrial(m) <==> neurofibromin1(h):glutamate dehydrogenase 1, mitochondrial(m) (binding) | neurofibromin1(h) + aspartate aminotransferase, cytoplasmic(m) <==> neurofibromin1(h):aspartate aminotransferase, cytoplasmic(m) (binding) | neurofibromin1(h) + 4-aminobutyrate aminotransferase, mitochondrial(m) <==> neurofibromin1(h):4-aminobutyrate aminotransferase, mitochondrial(m) (binding) | neurofibromin1(h) + 14-3-3epsilon(m) <==> neurofibromin1(h):14-3-3epsilon(m) (binding) | neurofibromin1(h) + 14-3-3beta(m) <==> neurofibromin1(h):14-3-3beta(m) (binding) | neurofibromin1(h) + Ferritin H(m) <==> neurofibromin1(h):Ferritin H(m) (binding) | neurofibromin1(h) + Hspa4(m) <==> neurofibromin1(h):Hspa4(m) (binding) | neurofibromin1(h) + GRP78(m) <==> neurofibromin1(h):GRP78(m) (binding) | neurofibromin1(h) + E1(m) <==> neurofibromin1(h):E1(m) (binding) | neurofibromin1(h) + uMtCK(m) <==> neurofibromin1(h):uMtCK(m) (binding) | neurofibromin1(h) + aldehyde dehydrogenase, mitochondrial(m) <==> neurofibromin1(h):aldehyde dehydrogenase, mitochondrial(m) (binding) | neurofibromin1(h) + malate dehydrogenase, cytoplasmic(m) <==> neurofibromin1(h):malate dehydrogenase, cytoplasmic(m) (binding) | neurofibromin1(h) + LDH-M(m) <==> neurofibromin1(h):LDH-M(m) (binding) | neurofibromin1(h) + aspartate aminotransferase, mitochondrial(m) <==> neurofibromin1(h):aspartate aminotransferase, mitochondrial(m) (binding) | neurofibromin1(h) + APG1(m) <==> neurofibromin1(h):APG1(m) (binding) | neurofibromin1(h) + Beta-1-globin(m) <==> neurofibromin1(h):Beta-1-globin(m) (binding) | neurofibromin1(h) + glutamine synthetase(m) <==> neurofibromin1(h):glutamine synthetase(m) (binding) | neurofibromin1(h) + p20arc(m) <==> neurofibromin1(h):p20arc(m) (binding) | neurofibromin1(h) + endophilin A1(m) <==> neurofibromin1(h):endophilin A1(m) (binding) | neurofibromin1(h) + GRP75(m) <==> neurofibromin1(h):GRP75(m) (binding) | MEM3(m) + neurofibromin1(h) <==> MEM3(m):neurofibromin1(h) (binding) | neurofibromin1(h) + PP2ACbeta(m) <==> neurofibromin1(h):PP2ACbeta(m) (binding) | neurofibromin1(h) + SDPI(m) <==> neurofibromin1(h):SDPI(m) (binding) | neurofibromin1(h) + M-MDH(m) <==> neurofibromin1(h):M-MDH(m) (binding) | neurofibromin1(h) + NDPKB(m) <==> neurofibromin1(h):NDPKB(m) (binding) | neurofibromin1(h) + Hsp90-alpha(m) <==> neurofibromin1(h):Hsp90-alpha(m) (binding) | neurofibromin1(h) + GAPD(m) <==> neurofibromin1(h):GAPD(m) (binding) | neurofibromin1(h) + beta-actin(m) <==> neurofibromin1(h):beta-actin(m) (binding) | neurofibromin1(h) + CRMP1(m) <==> neurofibromin1(h):CRMP1(m) (binding) | neurofibromin1(h) + Hsc70(m) <==> neurofibromin1(h):Hsc70(m) (binding) | neurofibromin1(h) + fumarate hydratase(m) <==> neurofibromin1(h):fumarate hydratase(m) (binding) | neurofibromin1(h) + Hsp90-beta(m) <==> neurofibromin1(h):Hsp90-beta(m) (binding) | neurofibromin1(h) + Tau(m) <==> neurofibromin1(h):Tau(m) (binding) | neurofibromin1(h) + vcp(m) <==> neurofibromin1(h):vcp(m) (binding) | neurofibromin1(h) + MBP(m) <==> neurofibromin1(h):MBP(m) (binding) | neurofibromin1(h) + hexokinase1(m) <==> neurofibromin1(h):hexokinase1(m) (binding) | neurofibromin1(h) + succinate semialdehyde dehydrogenase, mitochondrial(m) <==> neurofibromin1(h):succinate semialdehyde dehydrogenase, mitochondrial(m) (binding) | neurofibromin1(h) + Tfam(m) <==> neurofibromin1(h):Tfam(m) (binding) | neurofibromin1(h) + alpha-globin(m) <==> neurofibromin1(h):alpha-globin(m) (binding) | neurofibromin1(h) + Tubulin(m) <==> neurofibromin1(h):Tubulin(m) (binding) | neurofibromin1(h) + EF1A2(m) <==> neurofibromin1(h):EF1A2(m) (binding) | neurofibromin1(h) --> COL1A1(h) (DNA binding). | NF1(h) --> neurofibromin1(h) (expression). | NF1(h) --> neurofibromin1-isoform2(h) (expression). | NF1(h) --> neurofibromin1-isoform1(h) (expression). | NF1(h) --> neurofibromin1-isoform3(h) (expression). | NF1(h) --> neurofibromin1-isoform4(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
864 | Phosphoserine. | Swiss-Prot 53.0 | 2188 | Phosphoserine. | Swiss-Prot 53.0 | 2514 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 2515 | Phosphoserine. | Swiss-Prot 53.0 | 864 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 2515 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 2829 | Phosphoserine | 16083285 | Phospho.ELM 6.0 | 2188 | Phosphoserine | 16565220 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr17 |
Promoter: 26444621 - 26446621 | Agilent_014791 |
chr17 |
Promoter: 26444621 - 26446621 | GSE27584 |
chr17 |
Promoter: 26444621 - 26446621 | GSE27584 |
chr17 |
Promoter: 26444621 - 26446621 | Agilent_014791_44K |
chr17 |
Promoter: 26444621 - 26446621 | Agilent_014791_44K |