Entrez Gene

Basic Information
Gene ID	5411
Name	PNN
Synonymous	DRS\|DRSP\|SDK3\|memA;pinin, desmosome associated protein;PNN;pinin, desmosome associated protein
Definition	140 kDa nuclear and cell adhesion-related phosphoprotein\|SR-like protein\|desmosome-associated protein\|domain-rich serine protein\|melanoma metastasis clone A protein\|neutrophil protein\|nuclear protein SDK3\|pinin
Position	14q21.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
Pinin(h) + PRP4K(h) <==> Pinin(h):PRP4K(h) (binding)
Pinin(h) + PRP4K(h) <==> Pinin(h):PRP4K(h) (binding)
Ku70(h) + Ccte(h) + Pds5A(h) + PPIL1(h) + eIF-3gamma(h) + SAFB1(h) + Wapl(h) + Rad21(h) + SMC-3(h) + SMC1(h) + CAPER-alpha(h) + CNOT3(h) + NCoA-5(h) + SIAHBP1(h) + FBP(h) + HYPA(h) + SKIP(h) + SRm300(h) + SRm160(h) + p54nrb/NonO(h) + rbm25(h) + rbm8A(h) + Pinin(h) + Prp19(h) + cdc5L(h) + Snrp116(h) + Prpf8(h) + Sf3b-4(h) + Sf3b-2(h) + hnRNPM(h) + hnRNP-G(h) <==> Ku70(h):Ccte(h):Pds5A(h):PPIL1(h):eIF-3gamma(h):SAFB1(h):Wapl(h):Rad21(h):SMC-3(h):SMC1(h):CAPER-alpha(h):CNOT3(h):NCoA-5(h):SIAHBP1(h):FBP(h):HYPA(h):SKIP(h):SRm300(h):SRm160(h):p54nrb/NonO(h):rbm25(h):rbm8A(h):Pinin(h):Prp19(h):cdc5L(h):Snrp116(h):Prpf8(h):Sf3b-4(h):Sf3b-2(h):hnRNPM(h):hnRNP-G(h) (binding)
rnps1(h) + Pinin(h) <==> rnps1(h):Pinin(h) (binding)
IKBL(h) + Pinin(h) <==> IKBL(h):Pinin(h) (binding)
Keratin-18(h) + Pinin(h) <==> Keratin-18(h):Pinin(h) (binding)
Keratin-8(h) + Pinin(h) <==> Keratin-8(h):Pinin(h) (binding)
Keratin-19(h) + Pinin(h) <==> Keratin-19(h):Pinin(h) (binding)
Keratin(ca) + Pinin(h) <==> Keratin(ca):Pinin(h) (binding)
Pinin(h) + CAPER-alpha(h) <==> Pinin(h):CAPER-alpha(h) (binding)
PNN(h) --> Pinin(h) (expression).
Sfrs10(h) --> Pinin(h) (binding)
PNN(h) --> Pinin-1(h) (expression).
PNN(h) --> Pinin-2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
2	N-acetylalanine.		Swiss-Prot 53.0
66	Phosphoserine.		Swiss-Prot 53.0
100	Phosphoserine.		Swiss-Prot 53.0
347	Phosphoserine.		Swiss-Prot 53.0
381	Phosphoserine.		Swiss-Prot 53.0
441	Phosphoserine (By similarity).		Swiss-Prot 53.0
443	Phosphoserine.		Swiss-Prot 53.0
658	Phosphoserine.		Swiss-Prot 53.0
692	Phosphoserine.		Swiss-Prot 53.0
689	Phosphoserine	15302935	Phospho.ELM 6.0
442	Phosphoserine	16565220;17081983	Phospho.ELM 6.0
346	Phosphoserine	16565220;17081983	Phospho.ELM 6.0
65	Phosphoserine	17081983	Phospho.ELM 6.0
99	Phosphoserine	17081983	Phospho.ELM 6.0
380	Phosphoserine	17081983	Phospho.ELM 6.0
412	Phosphoserine	17081983	Phospho.ELM 6.0
656	Phosphothreonine	17081983	Phospho.ELM 6.0
657	Phosphoserine	17081983	Phospho.ELM 6.0
691	Phosphoserine	17081983	Phospho.ELM 6.0